Endometrial Neoplasia: Hyperplasia and Carcinoma

Kurman, Robert J.; Norris, Henry J.

doi:10.1007/978-1-4757-1767-9_13

Cited by 21 publications

(6 citation statements)

References 130 publications

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“…The transition from complex hyperplasia to endometrial cancer was reported to occur at rates of 26.7% by Wentz, 11 11.8% by Gusberg and colleagues, 12 and 10–15% by Kurman and coworkers, 13,14 illustrating the importance of detection of complex hyperplasia in preventing disease progression to more advanced stages.…”

Section: Discussionmentioning

confidence: 99%

Significance of hormone receptor status and tumor vessels in normal, hyperplastic and neoplastic endometrium

Nunobiki

Taniguchi

Ishii

et al. 2003

Pathology International

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The aims of this study were to identity the roles of tumor vessels and hormone receptor status in normal, hyperplastic, and neoplastic endometrium, and to explore their relationships with other prognostic factors of endometrial adenocarcinoma. Endometrial curettage specimens of proliferative phase and secretory phase endometrium, simple hyperplasia with or without atypia, complex hyperplasia with or without atypia, and grade 1 adenocarcinoma were examined for estrogen receptor alpha (ER alpha), progesterone receptor (PgR), Ki-67 labeling index (LI), cyclin D1, microvessel density (MVD), and area of venules (AV) using an immunoperoxidase method. The results showed high levels of ER alpha in complex hyperplasia, and high levels of PgR in simple hyperplasia without atypia. Expression of ER alpha in the endometrium decreased in a stepwise manner from complex hyperplasia without atypia to grade 1 adenocarcinoma. Expression of PgR in the endometrium decreased in a stepwise manner from simple hyperplasia without atypia to grade 1 adenocarcinoma. In contrast, the expressions of Ki-67 LI, cyclin D1, MVD and AV in the endometrium increased in a stepwise manner from normal, simple or complex hyperplasia with or without atypia to grade 1 adenocarcinoma. These changes may become irreversible on progression from simple or complex hyperplasia to neoplasia.

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Section: Discussionmentioning

confidence: 99%

Significance of hormone receptor status and tumor vessels in normal, hyperplastic and neoplastic endometrium

Nunobiki

Taniguchi

Ishii

et al. 2003

Pathology International

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“…18,19 In the present study, the fact that most of the samples were of the g1 adenocarcinoma may explain the failure to observe lower Bcl-2 expression in the endometrial carcinoma samples than in the endometrial hyperplasia samples. The transition from complex hyperplasia to endometrial cancer was reported by Wentz to occur at a rate of 26.7%, 20 by Gusberg and Kaplan to occur at 11.8%, 21 and by Kurman et al at 10-15%, 22,23 illustrating the importance of the detection of complex hyperplasia to prevent disease progression.…”

Section: Discussionmentioning

confidence: 94%

“…The transition from complex hyperplasia to endometrial cancer was reported by Wentz to occur at a rate of 26.7%, 20 by Gusberg and Kaplan to occur at 11.8%, 21 and by Kurman et al . at 10–15%, 22,23 illustrating the importance of the detection of complex hyperplasia to prevent disease progression.…”

Section: Discussionmentioning

confidence: 99%

Adrenomedullin, Bcl‐2 and microvessel density in normal, hyperplastic and neoplastic endometrium

Nunobiki¹,

Nakamura²,

Taniguchi³

et al. 2009

Pathology International

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Adrenomedullin (ADM) is a multifunctional 52-amino acid peptide involved in numerous physiological and pathological processes, including angiogenesis, growth regulation, differentiation, and vasodilation. ADM is thought to act through the G protein-coupled receptor calcitonin receptor-like receptor, with specificity being conferred by receptor-associated modifying protein 2. The aim of the present study was to clarify the roles of ADM status, and tumor vessels in endometrium. Specimens were examined for ADM, microvessel density (MVD), area of venules (AV) and Bcl-2 oncoprotein using an immunoperoxidase method. The difference of ADM between normal proliferative phase and hyperplasia without atypia was significant (P < 0.05). The level of Bcl-2 was significantly different between hyperplasia without atypia and hyperplasia with atypia (P < 0.05). ADM, MVD and AV in the endometrium increased in a stepwise manner from normal, simple or complex hyperplasia with or without atypia to grade 1 adenocarcinoma. In contrast, expression of Bcl-2 oncoprotein was decreased. These parameters identify the role of ADM expression and Bcl-2 protein in relation to cell growth and vasodilating in the neoplastic changes.

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“…The purpose of endometrial cytologic examination in mass screening is, in the first place, to correctly distinguish benign from malignant tumors. Transition from complex hyperplasia into endometrial cancer was reported to occur in 26.7% by Wentz, 19 in 11.8% by Gusberg et al 2 and in 10-15% by Kurman et al, 9 illustrating the importance of efficient detection of complex hyperplasia or beyond. 11 If a distinction between complex hyperplasia, of which progress is observable, and endometrial cancer, for which immediate treatment is necessary, becomes possible through cytologic examination, it will be possible to reduce endometrial curettage examinations to a minimum and to lighten the burden carried by the patient and clinician.…”

Section: Discussionmentioning

confidence: 99%

Criteria for Differential Diagnosis of Complex Hyperplasia or Beyond in Endometrial Cytology

Ishii¹,

Fujii²

1997

Acta Cytologica

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Endometrial Neoplasia: Hyperplasia and Carcinoma

Cited by 21 publications

References 130 publications

Significance of hormone receptor status and tumor vessels in normal, hyperplastic and neoplastic endometrium

Significance of hormone receptor status and tumor vessels in normal, hyperplastic and neoplastic endometrium

Adrenomedullin, Bcl‐2 and microvessel density in normal, hyperplastic and neoplastic endometrium

Criteria for Differential Diagnosis of Complex Hyperplasia or Beyond in Endometrial Cytology

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