Endometrial polyps: Is the prediction of spontaneous regression possible?

Abstract

Objective Endometrial polyps have been considered as a hyperplastic growth of endometrial stromal and glandular tissues. Even asymptomatic polyps in premenopausal women are usually removed as soon as they are diagnosed, although it is still unknown how often endometrial polyps disappear spontaneously. The aim of this study was to investigate the regression rate of endometrial polyps and the possible factors related to their spontaneous regression. Methods A total of 197 women with endometrial polyps were treated with operative hysteroscopy between January 2017 and April 2019 at our tertiary center. Of these, 123 patients who preferred conservative follow-up were enrolled in the study. Clinical and pathological data were obtained from electronic medical records. Results Patients with endometrial polyps were followed up for a median period of 62 days (range 30–360 days). Most women with endometrial polyps (84%) were reported to have gynecologic symptoms. Spontaneous polyp regression was observed in 28 (23%) patients who underwent surgery reevaluation. Patient age (<45 years), premenopausal period, and polyp size (<2 cm) were found to be associated with spontaneous endometrial polyp regression ( P <0.05). We also observed more polyp regression in women with abnormal uterine bleeding ( P =0.05). Second-look hysteroscopy showed that all postmenopausal women had persistent endometrial polyps. Conclusion Patient age (<45 years), premenopausal period, polyp size (<2 cm), and abnormal uterine bleeding may be associated with spontaneous endometrial polyp regression.

Surgical outcomes of laparoscopic trachelectomy following supracervical hysterectomy: a multicenter study

“…The length of hospital stay in the current study was 4 days (range, [4][5]. This was longer than that reported by Vieira et al [19] who reported a short hospital stay of 1 day (range, 1-3) in the minimally invasive group.…”

“…Cervical polyps may be indicative of cervical or endometrial pathologies. Recent studies have reported that cervical polyps were associated with premalignant lesions in 2% of cases, and more seriously, 0.3% were associated with malignant lesions [ 4 , 5 ]. Other common symptoms after supracervical hysterectomy are abnormal offensive discharge, chronic pelvic pain, and impaired sexuality.…”

Predictive factors of spontaneously regressed uterine endometrial polyps during the waiting period before hysteroscopic polypectomy

“…This result indicated the possibility that some endometrial polyps were regressed within several menstrual cycles. The rate of SRP was inversely related to the size of the target polyp, although the cut-off value for "Small polyp" was not consistent with a previous similar report [13]. Then, to identify significant factors for predicting SRP, we retrospectively extracted data on ten factors that seemed to be related to endometrial polyps.…”

Spectral Artificial Vision Endoscopy for Assisting the Differential Diagnosis of Endometrial Polyps, In Vivo

“…However, the identification and the discrimination between the different EPs types remain today a challenging clinical task, with great impact on treatment decision-making. Functional polyps, for example, usually disappear within a 2 to 3 month's period, most likely due to endometrial shedding during menstruation [18,19]. If not identified correctly, their removal will not alleviate patient's symptoms; while at the same time will increase the risks associated with a possible surgical overtreatment.…”