Endometrial Polyps

Impaired inflammatory state of the endometrium: a multifaceted approach to endometrial inflammation. Current insights and future directions

“…Furthermore, endometrial polyp (EP) is an anatomo-clinical entity that appears strongly related to IISE. It is a benign hyperplastic overgrowth of endometrial glands and stroma affecting 7.8% to 50% of women, with a prevalence of malignancy ranging from 1 to 3%, particularly in post-menopausal patients [97][98][99][100][101][102][103]. Spontaneous regression has been reported in 6.3 to 25% of cases [97,104].…”

“…Although its etiopathogenesis is still unknown, it is usually presented as a hormone-related condition [ 103 , 105 , 106 ]. Yet, there is to date sufficient evidence indicating an inflammation-mediated pathogenesis, especially as hormonal imbalances are demonstrated to interfere with the inflammatory state of the endometrium [ 65 , 99 , 106 ]. Risk factors for EP are those for chronic inflammation: increasing age, menopause, obesity and hypertension [ 99 , 102 ].…”

“…Yet, there is to date sufficient evidence indicating an inflammation-mediated pathogenesis, especially as hormonal imbalances are demonstrated to interfere with the inflammatory state of the endometrium [ 65 , 99 , 106 ]. Risk factors for EP are those for chronic inflammation: increasing age, menopause, obesity and hypertension [ 99 , 102 ]. Higher prevalence of EP has been reported in women with diabetes mellitus [ 107 - 109 ], adenomyosis [ 110 ], endometriosis [ 111 ] and CE [ 112 , 113 ].…”