Endometrial stem/progenitor cells and their role in the pathogenesis of endometriosis

Cousins, Fiona L.; O, Dorien F.; Gargett, Caroline E.

doi:10.1016/j.bpobgyn.2018.01.011

Cited by 119 publications

(100 citation statements)

References 68 publications

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“…In that way, MSC‐Sec would not lead to the over‐proliferation of endometrial stromal cells. This result indeed benefits the repair of endometrial injury because the over‐proliferation of stromal cells is associated with endometriosis, a disease which is characterized by endometrium outside the uterine cavity 7a,28…”

Section: Resultsmentioning

confidence: 97%

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell‐Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

Liu

Yang

et al. 2019

Adv Healthcare Materials

120

108

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Stem cell therapies have made strides toward the efficacious treatment of injured endometrium and the prevention of intrauterine adhesions, or Asherman's syndrome (AS). Despite this progress, they are limited by their risk of tumor formation, low engraftment rates, as well as storage and transportation logistics. While attempts have been made to curb these issues, there remains a need for simple and effective solutions. A growing body of evidence supports the theory that delivering media, conditioned with mesenchymal stem cells, might be a promising alternative to live cell therapy. Mesenchymal stem cell‐secretome (MSC‐Sec) has a superior safety profile and can be stored without losing its regenerative properties. It is versatile enough to be added to a number of delivery vehicles that improve engraftment and control the release of the therapeutic. Thus, it holds great potential for the treatment of AS. Here, a new strategy for loading crosslinked hyaluronic acid gel (HA gel) with MSC‐Sec is reported. The HA gel/MSC‐Sec treatment paradigm creates a sustained release system that repairs endometrial injury in rats and promotes viable pregnancy.

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Section: Resultsmentioning

confidence: 97%

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell‐Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

Liu

Yang

et al. 2019

Adv Healthcare Materials

120

108

View full text Add to dashboard Cite

show abstract

“…Although Sampson’s retrograde menstruation theory is the best-known explanation of the pathogenesis of endometriosis, it does not explain the occurrence of extraperitoneal endometriotic lesions. Studies are increasingly suggesting an association between adult stem cells and endometriosis progression, and such evidence has recently been reviewed [177,178]. Endometrium-derived stem/progenitor cells may be shed through the fallopian tube, thereby establishing endometriotic implants [177].…”

Section: Cell-based Therapy For Endometriosis Treatmentmentioning

confidence: 99%

“…Studies are increasingly suggesting an association between adult stem cells and endometriosis progression, and such evidence has recently been reviewed [177,178]. Endometrium-derived stem/progenitor cells may be shed through the fallopian tube, thereby establishing endometriotic implants [177]. Endometrial stem or progenitor cells have been identified as clonogenic cells in human endometria and as label-retaining or CD44 + cells in endometria of mice.…”

Section: Cell-based Therapy For Endometriosis Treatmentmentioning

confidence: 99%

“…Endometrial stem or progenitor cells have been identified as clonogenic cells in human endometria and as label-retaining or CD44 + cells in endometria of mice. Several markers for isolation of endometrial mesenchymal stem/stromal cells (emMSCs) have been used, including CD146, PDGFRβ, and SUSD2 [177]. These emMSCs have been isolated from eutopic and ectopic endometria in human biopsies [179,180,181,182,183,184].…”

Section: Cell-based Therapy For Endometriosis Treatmentmentioning

confidence: 99%

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Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

Lin

Chen

Chang

et al. 2018

IJMS

140

104

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Endometriosis is an estrogen-dependent inflammatory disease that affects up to 10% of women of reproductive age and accounts for up to 50% of female infertility cases. It has been highly associated with poorer outcomes of assisted reproductive technology (ART), including decreased oocyte retrieval, lower implantation, and pregnancy rates. A better understanding of the pathogenesis of endometriosis-associated infertility is crucial for improving infertility treatment outcomes. Current theories regarding how endometriosis reduces fertility include anatomical distortion, ovulatory dysfunction, and niche inflammation-associated peritoneal or implantation defects. This review will survey the latest evidence on the role of inflammatory niche in the peritoneal cavity, ovaries, and uterus of endometriosis patients. Nonhormone treatment strategies that target these inflammation processes are also included. Furthermore, mesenchymal stem cell-based therapies are highlighted for potential endometriosis treatment because of their immunomodulatory effects and tropism toward inflamed lesion foci. Potential applications of stem cell therapy in treatment of endometriosis-associated infertility in particular for safety and efficacy are discussed.

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“…It adopts multiple different physiological states during life including premenarche, menstrual cycling, pregnancy, and postmenopause. During reproductive years it undergoes cyclical breakdown, shedding, repair and remodelling in response to oscillating levels of oestrogen and progesterone which entail iterative restoration of the contiguity of the interrupted glandular epithelial sheet that is effected by stem cells within basal glands retained after menstruation 22-25 .…”

Section: Introductionmentioning

confidence: 99%

The mutational landscape of normal human endometrial epithelium

Moore

Leongamornlert

Coorens

et al. 2018

Preprint

107

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All normal somatic cells are thought to acquire mutations. However, characterisation of the patterns and consequences of somatic mutation in normal tissues is limited. Uterine endometrium is a dynamic tissue that undergoes cyclical shedding and reconstitution and is lined by a gland-forming epithelium. Whole genome sequencing of normal endometrial glands showed that most are clonal cell populations derived from a recent common ancestor with mutation burdens differing from other normal cell types and manyfold lower than endometrial cancers. Mutational signatures found ubiquitously account for most mutations. Many, in some women potentially all, endometrial glands are colonised by cell clones carrying driver mutations in cancer genes, often with multiple drivers. Total and driver mutation burdens increase with age but are also influenced by other factors including body mass index and parity. Clones with drivers often originate during early decades of life. The somatic mutational landscapes of normal cells differ between cell types and are revealing the procession of neoplastic change leading to cancer.

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Endometrial stem/progenitor cells and their role in the pathogenesis of endometriosis

Cited by 119 publications

References 68 publications

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell‐Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell‐Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

The mutational landscape of normal human endometrial epithelium

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