Endometrial thickness affects the outcome of in vitro fertilization and embryo transfer in normal responders after GnRH antagonist administration

Abstract

BackgroundThe goal of this study was to assess the association between endometrial thickness on the chorionic gonadotropin (hCG) day and in vitro fertilization and embryo transfer (IVF-ET) outcome in normal responders after GnRH antagonist administration.MethodsA retrospective cohort study was performed in normal responders with GnRH antagonist administration from January 2011–December 2013. Patients were divided into four groups according to endometrial thickness, as follows: <7 mm (group 1), > = 7- < 8 mm (group 2), > = 8- < 14 mm (group 3), and > =14 mm (group 4).ResultsA total of 2106 embryo transfer cycles were analyzed. The pregnancy rate (PR) was 44.87%.The clinical pregnancy rate, ongoing pregnancy rate and the implantation rate (17.28%, 13.79%, 10.17%, respectively) were significantly lower in group 1 compared to the other three groups (p < 0.05). The miscarriage rate was higher in patients with endometrial thickness less than 7 mm. The clinical pregnancy rate, ongoing pregnancy rate and implantation rate were highest in patients with endometrial thickness higher than 14 mm, but showed no difference in patients with those of endometrial thickness between 8-14 mm.ConclusionsThere is a correlation between endometrial thickness measured on hCG day and clinical outcome in normal responders with GnRH antagonist administration. The pregnancy rate was lower in patients with endometrial thickness less than 7 mm compared with patients with endometrial thickness more than 7 mm.

Back to life from frozen state

“…This difference was statistically significant. This finding was comparable with the previous studies 24,25 .…”

“…The endometrial thickness is routinely assessed prior to the embryo transfer. Different studies have looked at different cut offs of endometrial thickness 24,25 . We compared the success of implantation when the endometrial thickness is less than 8mm and more than 8mm.…”

GnRH antagonist for patients with polycystic ovary syndrome undergoing controlled ovarian hyperstimulation for in vitro fertilization and embryo transfer in fresh cycles

“…It has been revealed that the clinical pregnancy rate is <30%, and the live birth rate is <20% in patients with an endometrium thickness of ≤7 mm (21). Additionally, no significant difference has been identified in the clinical pregnancy and implantation rates with endometrial thicknesses in the 8-14 mm range compared with >14 mm (22).…”

Does low‐dose aspirin improve pregnancy rate in women undergoing frozen‐thawed embryo transfer cycle? A pilot double‐blind, randomized placebo‐controlled trial

“…In the present study, endometrial thickness did not significantly vary between the aspirin and placebo‐treated groups and all women had an endometrial thickness between 7 and 13 mm and round up to 97% of them ( n = 58) had an endometrial thickness of >8 mm. Furthermore, different studies have indicated that endometrial thickness of >7 mm is a prerequisite for a successful pregnancy . Our results also confirm the findings of other studies showing no significant differences in endometrial thickness between low‐dose aspirin‐treated women and control group during IVF or ICSI treatment .…”