Endometrial Thickness Measurement for Detecting Endometrial Cancer in Women With Postmenopausal Bleeding

Timmermans, Anne; Opmeer, Brent C.; Khan, Khalid S.; Bachmann, Lucas M.; Epstein, Elisabeth; Clark, T. Justin; Gupta, Janesh; Bakour, Shagaf H.; Bosch, T. Van den; Doorn, Helena C. van; Cameron, Sharon; Giusa, Maria; Dessole, Salvatore; Dijkhuizen, F. P. H. L. J.; Riet, Gerben ter; Mol, Ben Willem J.

doi:10.1097/aog.0b013e3181e3e7e8

Cited by 278 publications

(140 citation statements)

References 26 publications

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“…This endometrial thickness cutoff is applicable both in users and non-users of hormone replacement therapy [2]. Even though it has been suggested that it would be safer to use a cutoff of 3 mm to exclude endometrial cancer in women with postmenopausal bleeding [5], the 4 mm cutoff prevails in clinical practice.…”

Section: A Imaging Techniques In the Management Of Postmenopausal Blmentioning

confidence: 99%

Imaging techniques in the management of abnormal vaginal bleeding in non-pregnant women before and after menopause

Valentin

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

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Transvaginal ultrasound plays a pivotal role in the management of non-pregnant women with abnormal vaginal bleeding. No other imaging technique has a role in the triage of these women. In women with postmenopausal bleeding ultrasound is used to categorize women as being at low or high risk of endometrial cancer, the result of the ultrasound examination being the basis for further management. In women with abnormal vaginal bleeding before menopause the role of ultrasound is less clear, because some common causes of abnormal vaginal bleeding before menopause cannot be diagnosed with ultrasound, e.g. infection, dysfunctional bleeding or problems with intrauterine contraceptive devices or contraceptive pills. Nonetheless, transvaginal ultrasound may sometimes be helpful also in women with abnormal vaginal bleeding before menopause. In this chapter ultrasound findings in women with endometrial cancer, endometrial polyps, endometrial hyperplasia, adenomyosis, uterine myomas including submucuous myomas, and leiomyosarcoma will be presented and ultrasound based triage of women with postmenopusal bleeding described. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 2 AbstractTransvaginal ultrasound plays a pivotal role in the management of non-pregnant women with abnormal vaginal bleeding. No other imaging technique has a role in the triage of these women. In women with postmenopausal bleeding ultrasound is used to categorize women as being at low or high risk of endometrial cancer, the result of the ultrasound examination being the basis for further management. In women with abnormal vaginal bleeding before menopause the role of ultrasound is less clear, because some common causes of abnormal vaginal bleeding before menopause cannot be diagnosed with ultrasound, e.g. infection, dysfunctional bleeding or problems with intrauterine contraceptive devices or contraceptive pills. Nonetheless, transvaginal ultrasound may sometimes be helpful also in women with abnormal vaginal bleeding before menopause. In this chapter ultrasound findings in women with endometrial cancer, endometrial polyps, endometrial hyperplasia, adenomyosis, uterine myomas including submucuous myomas, and leiomyosarcoma will be presented and ultrasound based triage of women with postmenopusal bleeding described.

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Section: A Imaging Techniques In the Management Of Postmenopausal Blmentioning

confidence: 99%

Imaging techniques in the management of abnormal vaginal bleeding in non-pregnant women before and after menopause

Valentin

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

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“…18 With relation to endometrial carcinoma, a recent meta-analysis suggested reducing the cutoff point for endometrial thickness measured by transvaginal ultrasonography to 3mm with the objective of increasing the method's sensitivity for ruling out neoplasms in postmenopausal women with bleeding. 19 In our study, 15 women who did have abnormal hysteroscopic findings were not identified by ultrasound screening, taking normal endometrial thickness as less than 5 mm. Notwithstanding, just six of these 15 women had histologically active endometrial lesions and no cases of hyperplasia or neoplasm were observed.…”

Section: Discussionmentioning

confidence: 99%

Avaliação de morfologia e histologia endometrial de mulheres após a menopausa

Wolff¹,

Monte²,

Atti³

et al. 2010

Rev. Assoc. Med. Bras.

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“…Transvaginal ultrasonography measurement of an endometrial thickness of 5 mm or more has been shown to detect 95% of endometrial carcinomas in postmenopausal women. 8 The overlap of normal endometrial thickness with carcinoma limits the value of ultrasound in premenopausal women. Histochemical markers, e.g.…”

Section: Discussionmentioning

confidence: 99%

Fertility-sparing treatment in a young patient with complex atypical hyperplasia of the endometrium

Toit

2014

Southern African Journal of Gynaecological Oncology

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Endometrial Thickness Measurement for Detecting Endometrial Cancer in Women With Postmenopausal Bleeding

Abstract: Previous meta-analyses on endometrial thickness measurement probably have overestimated its diagnostic accuracy in the detection of endometrial carcinoma. We advise the use of cutoff level of 3 mm for exclusion of endometrial carcinoma in women with postmenopausal bleeding.

Cited by 278 publications

References 26 publications

Imaging techniques in the management of abnormal vaginal bleeding in non-pregnant women before and after menopause

Imaging techniques in the management of abnormal vaginal bleeding in non-pregnant women before and after menopause

Avaliação de morfologia e histologia endometrial de mulheres após a menopausa

Fertility-sparing treatment in a young patient with complex atypical hyperplasia of the endometrium

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