Endometrioid Adenocarcinoma Arising From Endometriosis of the Rectosigmoid

Kobayashi, Shigeru; Sasaki, Morio; Goto, Tatsuya; Asakage, Naoki; Sekiguchi, Masayuki; Suzuki, Takahisa; Tsukada, Kenji; Yamasaki, Shigetaka; Ukawa, Shiro

doi:10.1111/j.1443-1661.2009.00925.x

Cited by 25 publications

(27 citation statements)

References 18 publications

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“…Clinically, patients with extragonadal endometriosis have signs and symptoms according to lesion location; if it is the colon that is involved, they may present with rectorrhagia, intestinal obstruction, colicky pain, bowel habit changes, and constitutional syndrome (1,5). The malignant transformation of endometriotic lesions is well covered by the literature (1,6,7).…”

Section: Discussionmentioning

confidence: 96%

“…The key test for surgical specimens is immunohistochemical staining for cytokeratin-7 and cytokeratin-20, and for estrogen receptors (1,(10)(11)(12). Tumor tissue arising from the intestinal mucosa exhibits the following immunoreactivity profile: negative CK7, positive CK20, and negative estrogen receptors.…”

Section: Discussionmentioning

confidence: 99%

“…The gold standard in the diagnosis of intestinal endometriosis is exploratory laparotomy (1,3) and the pathological study of specimens.…”

Section: Discussionmentioning

confidence: 99%

“…It consists of the presence of hormone-responsive endometrium outside the endometrial cavity. Common sites include the ovaries, Fallopian tubes, pouch of Douglas, and cervix; extragonadal sites include the intestine, bladder, lungs, central nervous system, and even the skin (1). While malignant degeneration of an endometriotic site is a rare occurrence, it must be borne in mind particularly for lesions in the ovaries or bowel.…”

Section: Introductionmentioning

confidence: 99%

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Malignant degeneration of rectal endometriosis

García-Marín¹,

Pellicer-Franco²,

Soria-Aledo³

et al. 2015

Rev Esp Enferm Dig

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Background: Endometriosis is a relatively common disease among women with child-bearing potential, and rare before puberty or following menopause. It consists of the presence of hormoneresponsive endometrium outside the endometrial cavity.Case report: We report the case of a patient with a rectal lesion, initially approached as a primary rectal malignancy, where histopathology eventually revealed an adenocarcinoma arising from endometrial tissue in the colonic wall.Discussion: Endometriosis has an estimated rated of 10-20%. Sites may be split up into two larger categories -gonadal and extragonadal. The frequency of extragonadal endometriosis in the bowel is estimated to involve 3%-37% of women with pelvic endometriosis, and most lesions are found in the sigmoid colon and rectum. The malignant transformation of endometriotic lesions is estimated between 0.3% and 1% of cases. The gold standard in the diagnosis of intestinal endometriosis is exploratory laparotomy and the pathological study of specimens. Adjuvant radiotherapy and chemotherapy, although used for some patients, have not proven effective.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

“…The gold standard in the diagnosis of intestinal endometriosis is exploratory laparotomy (1,3) and the pathological study of specimens.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Malignant degeneration of rectal endometriosis

García-Marín¹,

Pellicer-Franco²,

Soria-Aledo³

et al. 2015

Rev Esp Enferm Dig

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“…2. Ugyanakkor, ha sikerül is preoperatívan felismerni, hogy endometriosis okozza a bélelzáródást, akkor is számolni kell az extragonadalis endometriosis malignus transzformációjára, ami az esetek 0,3-1%-ra tehető [40,41]. 3.…”

Section: Megbeszélésunclassified

Belet infiltráló endometriosis: a gasztroenterológia és a sebészet új kihívása? Vastagbélileust okozó endometriosis három esete és irodalmi áttekintés

et al. 2016

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Bevezetés: Az endometriosis miatt kezelt betegek száma az utóbbi évtizedekben nőtt és az esetek is előrehaladottab-bak. A belet infiltráló endometriosis legsúlyosabb szövődménye a vastagbélileus. A betegség ezen szövődményéről napjainkig 16 angol nyelvű, a betegek anamnézisét, kivizsgálását leíró esetismertetés jelent meg. Betegek: 2009 óta az I. Nőgyógyászati Klinikán endometriosissal kezelt 535 beteg közül három esetében korábban vastagbél-elzáródás miatt akut sebészeti beavatkozás történt. Eredmények: A betegek (13/21) 59%-ának anamnézisében endometriosisra utaló tünetek vagy endometriosis miatti korábbi kezelés szerepelt. A képalkotó vizsgálatok (ultrahangvizsgálat, komputertomográfia, mágneses rezonanciás vizsgálat) csak egy esetben vetették fel endometriosis gyanúját. Az esetek 61%-ában (13/21) a primer műtét előtt, 24%-ában (5/21) a műtét után történt kolonoszkópia, de egyetlen esetben sem merült fel endometriosis lehetősége. Bár minden esetben ileus alakult ki, a mucosa csupán 5%-ban (1/19) volt infiltrált. Következtetések: Fiatal nőbeteg ileusa hátterében endometriosis is állhat. A másodlagos kolonoszkópos jelek (falmerevség, megtöretés, benyomat) felismerésével a gasztroenterológus segítheti a preoperatív diagnózist, így megelőzhető a műtét felesleges kiterjesztése. Javasolt nőgyógyász bevonása a műtétbe. Orv. Hetil., 2016Hetil., , 157(49), 1960Hetil., -1966 Kulcsszavak: endometriosis, vastagbélileus, kivizsgálás, kolonoszkópia, műtét Bowel endometriosis: new challenge for gastroenterology and surgery? Three cases of endometriosis caused large bowel ileus and review of the literatureIntroduction: A number of the patients suffer from endometriosis increased in the past decades and the cases have became more serious. The most critical complication of bowel endometriosis is the large bowel obstruction. Up to recently, 16 similar case reports of large bowel endomteriosis causing obstruction, with detailed medical history have been published in the literature in English language. Patients: Since 2007 535 female have been treated in the 1st Gynaecological Department with endometriosis, out of them three patients from emergency surgery in the history because of large bowel obstruction. Results: Symptoms suggesting endometriosis or previous intervention due to endometriosis were detected in 59% (13/21) of the cases. Preoperative ultrasound, computertomography, magnetic resonance imaging did not give correct diagnosis. Colonoscopy was carried out before the primary operation in 61% (13/21) and after the surgery in 24% (5/21) of the cases, but none of them confirmed endometriosis. Although all the patients developed obstruction, only in 5% (1/19) of the patients was the mucosa infiltrated by the endometriosis. Conclusions: In a young female patient, intestinal obstruction can be caused by bowel endometriosis. Identification of colonoscopic signs (rigidity, impression, kinking) of endometriosis may help to avoid unnecessary extension of intestinal resection. Gynaecologists should take part in the operations.

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Malignant transformation of rectal endometriosis: Preoperative diagnosis by endorectal ultrasound guided biopsy

Liang

Cheng

Liu

et al. 2022

J of Clinical Ultrasound

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The prevalence of malignant transformation of endometriotic lesions is estimated between 0.3% and 1%. Malignant transformations of endometriosis occur in the colorectum is rarer, accounting for 0.25%. Because the malignant transformation of colorectal endometriosis rarely involves mucosa, it is difficult to obtain abnormal tissue by routine endoscopic biopsy. In this case, we evaluated a patient with a rectal mass by endorectal ultrasound (ERUS) and performed endorectal ultrasound‐guided biopsy (EGB). Malignant transformations of endometriosis were confirmed by histological result. For patients with rectal tumors but with negative findings on colonoscopy and biopsy, ERUS and EGB contribute to preoperative diagnosis.

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Endometrioid Adenocarcinoma Arising From Endometriosis of the Rectosigmoid

Cited by 25 publications

References 18 publications

Malignant degeneration of rectal endometriosis

Malignant degeneration of rectal endometriosis

Belet infiltráló endometriosis: a gasztroenterológia és a sebészet új kihívása? Vastagbélileust okozó endometriosis három esete és irodalmi áttekintés

Malignant transformation of rectal endometriosis: Preoperative diagnosis by endorectal ultrasound guided biopsy

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