Endometrioid carcinoma arising from endometriosis of the sigmoid colon during estrogenic treatment

Duun, Susanne; Roed-Petersen, K; Michelsen, Jens

doi:10.3109/00016349309021164

Cited by 37 publications

(38 citation statements)

References 11 publications

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“…23,24 It is postulated that the direct malignant transformation of the endometriotic implants in the colorectal tissue may be partly because of hyperestrogenism. 25 The marked increase of the CRC incidence in the endometrial cohort, more specifically, in women with adenomyosis coexistent with endometriosis of at least one extragonadal site, may result from the increase in the incidence of primary CRC and/or increased that of endometriotic implant-transformed carcinoma, such as clear cell carcinoma. However, we believe that the endometriotic malignant transformation theory can only explain for a small proportion of patients with primary CRCs, not for the most patients with adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

The Risks for Ovarian, Endometrial, Breast, Colorectal, and Other Cancers in Women With Newly Diagnosed Endometriosis or Adenomyosis: A Population-Based Study

Kok¹,

Tsai

et al. 2015

Int J Gynecol Cancer

106

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Section: Discussionmentioning

confidence: 99%

The Risks for Ovarian, Endometrial, Breast, Colorectal, and Other Cancers in Women With Newly Diagnosed Endometriosis or Adenomyosis: A Population-Based Study

Kok¹,

Tsai

et al. 2015

Int J Gynecol Cancer

106

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“…This case Serves to highlight the value of FNA in establishing a diagnosis prior to laparotomy. Dunn (9) records the only other reported case where FNA was used as a diagnostic tool. However, a high index of suspicion must be maintained in the presence of equivocal cytology.…”

Section: Discussionmentioning

confidence: 96%

“…Currently, there are more than 50 reported cases in the English literature (4). Of these, 8 involved cases of malignancy arising in extraovarian endometriosis following total abdominal hysterectomy and bilateral salpingo-oophorectomy whilst on unopposed oestrogen replacement (3)(4)(5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

Extraovarian Endometrioid Carcinoma Associated with Unopposed Oestrogen Replacement Therapy

Sidhu

Edwards

Rainer

et al. 1998

Aust NZ J Obst Gynaeco

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EDITORIAL COMMENT We accepted this case report for publication because, apart from being interesting, it raises the question of the appropriate hormone replacement therapy after bilateral oophorectomy (usually with hysterectomy) has been performed when there is evidence of endometriosis. Menopausal symptoms in these women can be relieved by oestrogen therapy without return of pelvic pain or dyspareunia. The authors report a case of endometrial-like carcinoma in a woman with known endometriosis after a hysterectomy and prolonged unopposed oestrogen therapy, Although this is a solitary case report, the authors explain that there are 8 others in the literature where malignancy occurred in extraovarian endometriosis after bilateral oophorectomy associated with unopposed aestrogen. One of our reviewers commented that a combination of oestrogen and progestogen should always be considered when prescribing hormone replacement therapy in women with a known history of endometriosis, following total hysterectomy and bilateral oophorectomy.Carcinoma of the endometrium is the most common female genital cancer, with endometrioid adenocarcinoma being the most common histological subtype. The association between the development of endometrial adenocarcinoma and unopposed oestrogen therapy is well recognized (1). Far less common is the development of carcinoma in intraabdominal foci of endometriosis (2).Brooks and Wheeler (3) undertook the first major review of all cases of extraovarian endometriotic malignancy. Currently, there are more than 50 reported cases in the English literature (4). Of these, 8 involved cases of malignancy arising in extraovarian endometriosis following total abdominal hysterectomy and bilateral salpingo-oophorectomy whilst on unopposed oestrogen replacement (3-9).We present a case of Sertoliform variant of endometrioid carcinoma arising in a pelvic focus of endornetriosis following total abdominal hysterectomy (TAH) and bilateral salpingo-oophorectomy (BSO) whilst on long-term unopposed oestrogen replacement. CASE REPORTA 60-year-old gravida 4, para 4, underwent TAH and BSO in Germany in 1978 when aged 42 years. Surgery was indicated for unmanageable pain and menorrhagia secondary to endometriosis. Postoperatively,

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“…The progression to invasive cancer has been related with hyperestrogenism, either of endogenous or of exogenous origin [8]. A possible genetic background favoring the onset of cancer has been reported in some patients without hyperestrogenism and with a family history of cancer [9].…”

Section: Discussionmentioning

confidence: 99%

“…Radiotherapy has been given in some cases [1,4,8,14], especially in patients with limited pelvic involvement. Yantis et al .…”

Section: Discussionmentioning

confidence: 99%

Metachronic malignant transformation of small bowel and rectal endometriosis in the same patient

et al. 2006

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Endometrioid carcinoma arising from endometriosis of the sigmoid colon during estrogenic treatment

Cited by 37 publications

References 11 publications

The Risks for Ovarian, Endometrial, Breast, Colorectal, and Other Cancers in Women With Newly Diagnosed Endometriosis or Adenomyosis: A Population-Based Study

The Risks for Ovarian, Endometrial, Breast, Colorectal, and Other Cancers in Women With Newly Diagnosed Endometriosis or Adenomyosis: A Population-Based Study

Extraovarian Endometrioid Carcinoma Associated with Unopposed Oestrogen Replacement Therapy

Metachronic malignant transformation of small bowel and rectal endometriosis in the same patient

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