Endometrioid carcinoma of the ovary: Retrospective review of 145 cases

Kline, Richard; Jt, Wharton; Atkinson, E. Neely; Burke, T.; Gershenson, D. M.; Edwards, Cynthia

doi:10.1016/0020-7292(91)90779-5

Cited by 25 publications

(38 citation statements)

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“…In a study done by Kline et al including 145 cases of ovarian endometrioid carcinoma, no significant difference was found between grades 1 and 2, whereas this difference was significant for grade 3 tumors. 38 In another study by Grosso et al of 106 cases, tumor grade showed prognostic significance in the univariate analysis but not in the multivariate analysis of all factors affecting survival. 39 In the study by Shimizu et al, 40 nuclear grade and mitotic count were found to be independent from architectural features in ovarian endometrioid carcinoma.…”

Section: Discussionmentioning

confidence: 94%

Low membranous expression of β-catenin and high mitotic count predict poor prognosis in endometrioid carcinoma of the ovary

et al. 2010

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Mutations in the b-catenin gene are common in ovarian endometrioid carcinoma. Few studies have addressed the association of b-catenin expression with tumor characteristics and patient outcome, yielding controversial results. The purpose of this study was to retrospectively assess the expression of b-catenin in ovarian endometrioid carcinoma and correlate its expression with the Gynecologic Oncology Group's (GOG) grading system, clinicopathological characteristics, and patient survival. A total of 49 patients with primary ovarian endometrioid carcinoma were included in this study. A four-tier score grading system was used for the membranous staining (negative, weak, moderate, and strong) and the percentage of positive cells for the nuclear staining of b-catenin. The status of five morphometric parameters, nuclear morphology (uniform or pleomorphic), mitotic count, glandular pattern, degree of squamous differentiation, and status of papillary pattern, was assessed. We found that a low membranous expression of b-catenin and a high mitotic count (415 per 10 high-power fields) were significantly associated with poor prognosis and early recurrence of ovarian endometrioid carcinoma. In addition, cases with nuclear expression of b-catenin showed an intermediate overall survival risk and late disease recurrence. Young age at the time of diagnosis, advanced disease stage, and suboptimal debulking were among the clinical factors predicting poor survival and early disease recurrence. The presence of squamous differentiation, a papillary pattern or nuclear pleomorphism did not show any correlation with overall survival or disease-free survival. Low membranous expression of b-catenin and high mitotic count are poor prognostic indicators in patients with ovarian endometrioid carcinoma, whereas the GOG grading system showed no prognostic value. Our data suggest that there is a need to define a better grading system for ovarian endometrioid carcinoma. Molecular markers such as b-catenin and mitotic count could aid in defining this grading system.

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Section: Discussionmentioning

confidence: 94%

Low membranous expression of β-catenin and high mitotic count predict poor prognosis in endometrioid carcinoma of the ovary

et al. 2010

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“…Patients with low-stage disease have, until recently, only uncommonly undergone a comprehensive staging procedure. The criteria separating endometrioid and mucinous borderline tumors from carcinomas have undergone significant changes, 1,2,17,20 which might have affected outcome Invasion patterns in ovarian carcinomas S Chen et al data in the older literature; [3][4][5][6][7][8][9][10][11][12][13][14][15][16]18,19 furthermore, the more recently proposed criteria, while significantly better than those previously used, can be difficult to apply. Also, as is now widely appreciated, many mucinous tumors, particularly with mostly borderline or only focally malignant features, represent metastases to ovaries, not primary ovarian mucinous neoplasms.…”

Section: Discussionmentioning

confidence: 99%

“…Although there are numerous articles in the literature that discuss the clinicopathologic features of endometrioid and mucinous carcinomas, [3][4][5][6][7][8][9][10][11][12][13][14][15][16]18,19 most do not specify the type of invasion required to diagnose carcinoma. The study by de Nictolis et al, 7 however, reports that destructive stromal invasion was not seen in any stage IA mucinous ovarian adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…There have been numerous clinicopathologic reports of mucinous ovarian adenocarcinomas and endometrioid adenocarcinomas, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] but none have focused specifically on the importance of invasion patterns. Three relatively recent publications, two dealing with mucinous ovarian adenocarcinomas 1,17 and one with endometrioid adenocarcinomas, 2 have described in detail histologic patterns of invasion, but these papers primarily emphasized criteria distinguishing borderline tumors from carcinomas and primary ovarian carcinomas from metastases.…”

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confidence: 99%

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Invasion patterns in stage I endometrioid and mucinous ovarian carcinomas: a clinicopathologic analysis emphasizing favorable outcomes in carcinomas without destructive stromal invasion and the occasional malignant course of carcinomas with limited destructive stromal invasion

et al. 2005

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Stage I, low-grade endometrioid and mucinous ovarian carcinomas have an excellent prognosis. Published data have suggested that destructive stromal invasion, a relatively uncommon finding in these tumors, is a poor prognostic factor. We investigated this by studying all FIGO stage I, grades 1 and 2 (of 3) endometrioid and mucinous ovarian carcinomas that were surgically staged at the Memorial Sloan-Kettering Cancer Center from 1980 to 2000. We undertook a careful review of all available slides using current diagnostic criteria and correlated histopathologic indices with clinical outcome data. Cases studied included 13 endometrioid ovarian carcinomas (stage IA, eight; stage IC, five) and six intestinal mucinous ovarian carcinomas (stage IA, three; stage IC, three). All of the tumors contained areas of expansile invasion, greater than that acceptable for microinvasion, and were thus diagnosed as carcinomas instead of borderline tumors. Nevertheless, nearly all demonstrated borderline tumor (noninvasive) components. Six tumors contained at least one focus of destructive stromal invasion (two endometrioid and four mucinous ovarian carcinomas). Four additional cases showed a focus suspicious for but not diagnostic of destructive invasion ('indeterminate for destructive invasion') (two endometrioid and two mucinous ovarian carcinomas). Follow-up data were available for 17 patients. The median follow-up was 81 months (range, 9-161 months). In all, 14 patients were alive with no evidence of disease (expansile invasion alone, eight; destructive stromal invasion, four; and indeterminate for destructive invasion, two). Three patients died of their disease (destructive stromal invasion, two; and indeterminate for destructive invasion, one). The size, number, and nuclear grade of destructive stromal invasion foci did not appear to have an impact on survival in this relatively limited number of patients. Outcome data in patients with stage I, low-grade endometrioid and mucinous ovarian carcinomas without destructive stromal invasion indicate that these tumors have a very limited malignant potential. The literature has not documented recurrences in this setting when the staging has been complete, the sampling adequate, and the cytologic features no more than grade 2, and metastasis to the ovary has been excluded. In contrast, carcinomas harboring even limited foci of destructive stromal invasion, although frequently cured surgically, can pursue a malignant clinical course. Modern Pathology (2005) 18, 903-911.

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“…[1][2][3][4] The presence of a solid component on magnetic resonance (MR) imaging distinguishes endometrioma from endometrioma associated with malignant tumor. [1][2][3][4] We describe a case of polypoid endometriosis of the ovary and discuss the key for diŠerential diagnosis.…”

Section: Introductionmentioning

confidence: 99%

MR Imaging of Polypoid Endometriosis of the Ovary

et al. 2012

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We report a case of polypoid endometriosis of the ovary and correlate magnetic resonance (MR) and pathologicalˆndings. The endometriosis appeared as multiple polypoid areas along the wall of the ovarian cystic lesion with hyperintensity on T 2 -weighted images and slight hyperintensity on diŠusion-weighted images. However, the polypoid areas did not yield low apparent diŠusion coe‹cient (ADC) values on ADC map images. These MRˆndings were similar to the signal intensity of the uterine endometrium, re‰ect-ing the presence of abundant endometrial glands.

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Endometrioid carcinoma of the ovary: Retrospective review of 145 cases

Cited by 25 publications

References 0 publications

Low membranous expression of β-catenin and high mitotic count predict poor prognosis in endometrioid carcinoma of the ovary

Low membranous expression of β-catenin and high mitotic count predict poor prognosis in endometrioid carcinoma of the ovary

Invasion patterns in stage I endometrioid and mucinous ovarian carcinomas: a clinicopathologic analysis emphasizing favorable outcomes in carcinomas without destructive stromal invasion and the occasional malignant course of carcinomas with limited destructive stromal invasion

MR Imaging of Polypoid Endometriosis of the Ovary

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