Endometriosis: a premenopausal disease? Age pattern in 42,079 patients with endometriosis

Haas, Dietmar; Chvatal, Radek; Reichert, Björn; Renner, Stefan P.; Shebl, Omar; Binder, Helge; Wurm, Peter; Oppelt, Peter

doi:10.1007/s00404-012-2361-z

Cited by 125 publications

(78 citation statements)

References 23 publications

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“…This is in comparison to women aged 25–34 (RR – 4.0) and 45–54 (RR - 4.5), respectively [5]. However, endometriosis is also frequently diagnosed in symptomatic post-menopausal women (incidence of 2.55%) [8]. It is possible that an increase in endometriosis can be attributed, in part, to the aging of the global population.…”

Section: Introductionmentioning

confidence: 99%

Molecular aspects of development and regulation of endometriosis

Aznaurova

Жуматаев

Roberts

et al. 2014

Reprod Biol Endocrinol

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Endometriosis is a common and painful condition affecting women of reproductive age. While the underlying pathophysiology is still largely unknown, much advancement has been made in understanding the progression of the disease. In recent years, a great deal of research has focused on non-invasive diagnostic tools, such as biomarkers, as well as identification of potential therapeutic targets. In this article, we will review the etiology and cellular mechanisms associated with endometriosis as well as the current diagnostic tools and therapies. We will then discuss the more recent genomic and proteomic studies and how these data may guide development of novel diagnostics and therapeutics. The current diagnostic tools are invasive and current therapies primarily treat the symptoms of endometriosis. Optimally, the advancement of “-omic” data will facilitate the development of non-invasive diagnostic biomarkers as well as therapeutics that target the pathophysiology of the disease and halt, or even reverse, progression. However, the amount of data generated by these types of studies is vast and bioinformatics analysis, such as we present here, will be critical to identification of appropriate targets for further study.

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Section: Introductionmentioning

confidence: 99%

Molecular aspects of development and regulation of endometriosis

Aznaurova

Жуматаев

Roberts

et al. 2014

Reprod Biol Endocrinol

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“…Hence, the teenagers included might have been the ones with most severe symptoms and more likely to have endometriosis. A recent report from Germany showed that 0.05%, 1.93% and 6.1% of patients were in 10-14, 15-19 and 20-24 year age groups respectively (Haas et al [8]). These numbers suggest that endometriosis is less likely to be diagnosed in girls under the age of 20 years, compared to older women.…”

mentioning

confidence: 96%

Adolescent endometriosis

Sarıdoğan

2017

European Journal of Obstetrics & Gynecology and Reproductiv

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Endometriosis is a common finding in adolescents who have a history of chronic pelvic pain or dysmenorrhoea resistant to medical treatment, however the exact prevalence is unknown. Both early/superficial and advanced forms of endometriosis are found in adolescents, including ovarian endometriomas and deep endometriotic lesions. Whilst spontaneous resolution is possible, recent reports suggest that adolescent endometriosis can be a progressive condition, at least in a significant proportion of cases. It is also claimed that deep endometriosis has its roots in adolescence. Optimum treatment is far from clear and long term recurrence is still a significant problem. The most frequently reported treatment approach in the published literature is a combination of surgery and postoperative hormonal treatment with the combined oral contraceptives, progestins, levonorgestrel intrauterine system or gonadotrophin releasing hormone analogues. Use of gonadotrophin releasing hormone analogues and long term progestins should be carefully considered due to concerns over continuing bone formation in this age group. There is currently no consensus as to whether surgery should be avoided as much as possible to prevent multiple operations in the long term, or surgical treatment should be considered at an early stage before more severe lesions develop. Further research is required to determine which approach would offer a better long term outcome.

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“…samples of women laparoscopically and/or histologically diagnosed with various reproductive pathologies, encompassing ~35% of endometriosis and another ~61% of various pathologies that affect the ovary and other upper genital tract parts. According to the Haas et al's study (9), 78.6% of our women with endometriosis fall into the premenopausal group (age, ≤40 years) and 21.4% into perimenopausal group (age, 41 to 50 years). The relationship between endometriosis and bacterial infection, that has been prompted by the high incidence of disease together with the observation of pathological lesions resembling punctate blister-like lesions (23), was not clarified until recently.…”

Section: Articlementioning

confidence: 80%