Endometriosis and cancer

Kajiyama, Hiroaki; Suzuki, Shiro; Yoshihara, Masato; Tamauchi, Satoshi; Yoshikawa, Nobuhisa; Niimi, Keiko; Shibata, Kiyosumi; Kikkawa, Fumitaka

doi:10.1016/j.freeradbiomed.2018.12.015

Cited by 114 publications

(87 citation statements)

References 76 publications

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“…In our study, it was observed that in higher stages of endometriosis, the total FSFI score was lower. It was shown in a study that women with deep in ltrating endometriosis have a SF impairment [16].…”

Section: Discussionmentioning

confidence: 99%

“…The FSFI is a 19-item patient-reported outcome measure consisting of 6 separate domains of female sexual function, desire (items 1-2), arousal (3-6), lubrication (7-10), orgasm (11)(12)(13), satisfaction (14)(15)(16), and pain (17-19) [18]. Initial validation showed a good internal consistency for all scales in a general population study sample, as well as in subgroups of FSD (female sexual dysfunction) patients and control subjects (Cranach's a = 0.82-0.97).…”

Section: Methodsmentioning

confidence: 99%

“…Multiple studies have shown that oxidative stress also plays an important role in the pathophysiological mechanism of male sexual dysfunction [11][12][13]. Based on this fact, it is assumed that oxidative stress may also play a role in the mechanism of female sexual dysfunction [14].Considering the increasing prevalence of PCOS (from 5-10% in the majority of the studies) [15] and endometriosis (estimated prevalence of 10%) [16] and their impact on fertility and sexual life, this study aims to compare the SF of infertile women having either of these two diseases with the control group.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Sexual Function in Infertile Women with Polycystic Ovary Syndrome and Endometriosis: A cross-sectional Study

Daneshfar¹,

Sadatmahalleh²,

Jahangiri³

2020

Preprint

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Introduction: Infertility is one of the issues affecting sexual function (SF). Infertility is also one of the complications of polycystic ovary syndrome (PCOS) and endometriosis. This research seeks to assess and compare SF and the prevalence of sexual dysfunction with PCOS and endometriosis in infertile women. Methods: A cross-sectional study was carried out on 630 samples (210 infertile women with endometriosis, 210 infertile women with PCOS, and 210 healthy women of childbearing age as the control group). SF was assessed by the Female Sexual Function Index (FSFI). Descriptive statistics and inferential statistics (One Way ANOVA and logistic regression) were used to analyze the data.Results: The results showed that the mean score of total FSFI in the two groups of PCOS and endometriosis was lower than the control group (P<0.001). In addition, women with higher education (university education) had a significantly higher score of total FSFI. Conclusion: Sexual dysfunction rates are high in infertile women with endometriosis and PCOS, so infertility service providers in infertility centers need to pay attention to this issue.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of Sexual Function in Infertile Women with Polycystic Ovary Syndrome and Endometriosis: A cross-sectional Study

Daneshfar¹,

Sadatmahalleh²,

Jahangiri³

2020

Preprint

View full text Add to dashboard Cite

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“…Endometriosis is frequently being recognized as a precursor lesion of endometriosis-associated carcinoma (EAC) in clinical set up [52][53][54][55]. It is generally believed that endometriosis -due to transdifferentiation of specialized peritoneal mucosal cells into endometrial cells in the metaplastic foci within a setting of chronic inflammation -may make the lesions predisposed to neoplastic transformation [54,55].…”

Section: Endometriosis-associated Cancersmentioning

confidence: 99%

How Benign is Endometriosis: Multi-Scale Interrogation of Documented Evidence

Ghosh

Anupa

et al. 2019

COGO

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Endometriosis is an inflammatory disease characterized by the presence of endometrium-like tissue outside the uterus primarily on pelvic organs and tissues. It affects up to 15% of women in the reproductive age group and is often associated with pelvic pain and subfertility. Different theories explain how retrograde menstruation gives rise to endometrial deposits at ectopic sites, and how several other factors are involved in the progression of the disease. Its final diagnosis is established through direct visualization at laparoscopy or surgery followed by histological confirmation. Available epidemiological reports along with histopathological observations and molecular studies shed interesting light on the pathogenetic basis of different variants of the disease like deep infiltrating endometriosis and ovarian endometriosis. Evidence also suggests that endometriosis is a neoplastic condition which serves as a precursor of ovarian and endometrial cancers. In the present review, we have attempted to take a stock of the current epidemiological and molecular knowledge regarding endometriosis associated cancers and develop a model of functional network with interactions among critical genomic factors regulating cellular processes leading to fibrotic reaction. It is being conjectured that cyclic bleeding associated with inflammatory and oxidative stress followed by repeated tissue injury and repair along with recurrent estrogenic stimulation and ovulatory events in the pelvic environment bring about the complex phenotype of atypical endometriosis and associated neoplasm with a trade-off malignant transformation in high risk population. Finally, we have presented an algorithm for pre-emptive monitoring and management of endometriosis-associated cancers.

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“…Endometriosis (EMS), the presence of endometrial-like tissue outside the uterus, is a chronic gynaecological disease which affects approximately 10% of reproductive-aged women 1 .EMS morbidity has displayed a marked increasing trend in recent years 2 .It has been recognized as a precursor lesion of several types of malignancies and endometriosis-associated carcinoma, such as clear cell carcinoma, endometrioid carcinoma and seromucinous borderline tumor 3 .Patients suffering from EMS typically experience chronic pelvic pain, infertility, or both, but can also be asymptomatic. Unfortunately, the pathogenesis of EMS remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Exosomal miRNAs as novel potential biomarkers for endometriosis

Zhang

Líu

Zhu

et al. 2020

Preprint

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Background: Endometriosis (EMS) is a chronic gynaecological disease. Exosomal miRNAs appear to be associated with the progression of EMS, which suggest potential circulating biomarkers in EMS.Methods: Differential centrifugation, illumina small RNA sequencing, bioinformatics analysis and qRT-PCR are used to compare the pelvic fluid of patients with a clinical diagnosis of EMS and matched controls.Results: Six miRNAs (miR-135a-5p, miR-196a-5p, miR-449b-5p, miR-4454, miR-4286, and miR-5100) showed significant differences in the EMS group in initial screening (log2FC > 2). Receiver-operator curve (ROC) analysis further indicated miR-4454 (area under the curve (AUC) = 0.956, P < 0.05) and miR-5100(area under the curve (AUC) = 0.900, P < 0.05) were highly correlated with the pathogenesis of EMS. Validation on the samples from 10 patients and 10 healthy people.Conclusion: Our miRNA expression data provide altered expression and potential prospects for biomarkers in EMS.

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Endometriosis and cancer

Cited by 114 publications

References 76 publications

Comparison of Sexual Function in Infertile Women with Polycystic Ovary Syndrome and Endometriosis: A cross-sectional Study

Comparison of Sexual Function in Infertile Women with Polycystic Ovary Syndrome and Endometriosis: A cross-sectional Study

How Benign is Endometriosis: Multi-Scale Interrogation of Documented Evidence

Exosomal miRNAs as novel potential biomarkers for endometriosis

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