Endometriosis and Cancer: Epidemiology

Viganò, Paola; Somigliana, Edgardo; Parazzini, Fabio; Vercellini, Paolo

doi:10.1002/9781444398519.ch49

Cited by 2 publications

(1 citation statement)

References 87 publications

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“…1 It is a common gynecological pathology, affecting one in every ten women in the general population. 2 Endometriosis can be didactically classified as peritoneal, ovarian, and deep, the latter being defined as the presence of invasion by more than 5 mm of the peritoneal tissue. 3 4…”

Section: Introductionmentioning

confidence: 99%

Correlation between Anatomopathological Aspects and Pelvic Pain in Women with Deep Infiltrating Endometriosis

Yela,

Silva,

Eloy

et al. 2023

Rev Bras Ginecol Obstet

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Objective To correlate the morphological aspects with pelvic pain in women with deep infiltrating endometriosis. Methods A retrospective study with 67 women with deep endometriosis who underwent surgical treatment in a tertiary hospital from 2007 to 2017. The following variables were considered: age, parity, body mass index, site of involvement, hormonal treatment before surgery, pelvic pain, and morphometric analysis. The histological slides of the surgical specimens were revised and, using the ImageJ software for morphometric study, the percentages of stromal/glandular tissues were calculated in the histological sections. Results The mean age of the women was 38.9 ± 6.5 years. The mean pain score was 8.8 ± 1.9 and the mean time of symptomatology was 4.7 ± 3.5 years, with 87% of the patients undergoing hormone treatment prior to surgery. The average expression of CD10, CK7, and S100 markers was 19.5 ± 11.8%, 9.4 ± 5.9%, and 7.9 ± 5.8% respectively. It was found that the greater the expression of CD10, the greater the level of pain (p = 0.02). No correlation was observed between the expression of CD10, CK7, and S100 markers and age and duration of symptoms. Conclusion Women with deep infiltrating endometriosis have a positive association between the level of pain and the fibrosis component in the endometrial tissue's histological composition.

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Section: Introductionmentioning

confidence: 99%

Correlation between Anatomopathological Aspects and Pelvic Pain in Women with Deep Infiltrating Endometriosis

Yela,

Silva,

Eloy

et al. 2023

Rev Bras Ginecol Obstet

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Non-coding RNAs in endometriosis: a narrative review

Panir

Schjenken

Robertson

et al. 2018

Human Reproduction Update

127

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There is a compelling case that microRNAs, long non-coding RNAs and short inhibitory RNAs have the potential to influence endometriosis development and persistence through modulating inflammation, proliferation, angiogenesis and tissue remodelling. Rapid advances in ncRNA biomarker discovery and therapeutics relevant to endometriosis are emerging. Unravelling the significance of ncRNAs in endometriosis will pave the way for new diagnostic tests and identify new therapeutic targets and treatment approaches that have the potential to improve clinical options for women with this disabling condition.

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Endometriosis and Cancer: Epidemiology

Cited by 2 publications

References 87 publications

Correlation between Anatomopathological Aspects and Pelvic Pain in Women with Deep Infiltrating Endometriosis

Correlation between Anatomopathological Aspects and Pelvic Pain in Women with Deep Infiltrating Endometriosis

Non-coding RNAs in endometriosis: a narrative review

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