Endometriosis and cancerogenesis of the ovaries (a review)

Adamyan, L. V.; Martirosyan, Ya. O.; Асатурова, А. В.

doi:10.17116/repro2018240417

Probl. reprod.

2018

DOI: 10.17116/repro2018240417

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Endometriosis and cancerogenesis of the ovaries (a review)

L. V. Adamyan¹,

Ya. O. Martirosyan²,

А. В. Асатурова³

Abstract: Эндометриоз встречается у 15% женщин репродуктивного возраста. Данные большинства исследований позволяют говорить о повышенном риске развития рака яичников у данной группы пациенток. Эндометриоз-ассоциированные опухоли чаще всего представлены эндометриоидным и светлоклеточным подтипами рака, меньшую долю составляют серомуцинозные опухоли. В данном обзоре обсуждаются генетические и молекулярные факторы, лежащие в основе злокачественной трансформации эндометриоза.

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2024

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Cited by 3 publications

References 30 publications

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The role of ARID1A in malignant neoplasms of the female reproductive system: a modern view on the possibilities of diagnosis and therapy

Marzaganova,

Martirosyan,

Korchemkina

et al. 2024

Akušerstvo, ginekologiâ i reprodukciâ

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Сhromatin remodeling tumor suppressor protein ARID1A (AT-rich interaction domain 1A) is coded by the ARID1A gene that is one of the most frequently mutated genes of human oncological diseases. Inactivating mutations in the ARID1A gene have a pronounced effect on cell survival, chemoresistance, transcription and regulation of the cell cycle. To date, a large number of studies have focused on assessing the effect of mutations leading to loss of ARID1A function on the occurrence, progression and resistance of tumors to therapy. The high frequency of ARID1A mutations in malignant tumors of the female reproductive system opens up unique opportunities for targeted preventive and therapeutic intervention. Clear cell carcinoma of the ovaries and uterine body cancer with ARID1A mutations do not respond well to standard chemotherapy and, to date, do not have effective targeted therapy, which underlines the need for further research in this area. ARID1A can be used as a biomarker of precancerous diseases, as well as as a tool for predicting the response to radiation therapy, immunotherapy and targeted therapies. Currently, clinical trials of several low molecular weight and epigenetic inhibitors are being conducted in tumors of the female reproductive system with ARID1A deficiency.

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The role of ARID1A in malignant neoplasms of the female reproductive system: a modern view on the possibilities of diagnosis and therapy

Marzaganova,

Martirosyan,

Korchemkina

et al. 2024

Akušerstvo, ginekologiâ i reprodukciâ

View full text Add to dashboard Cite

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The effect of progestagens on immunological risk factors of preterm birth

Elizarova

Артымук

Поленок

2019

Fundamentalʹnaâ i kliničeskaâ medicina

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Aim. To determine the level of IgA and IgG to estradiol, progesterone, and benzo[a]pyrene in women with or without preterm labor and to assess whether the administration of progestagens affect these parameters.Materials and Methods. We measured the levels of IgA and IgG to estradiol, progesterone, and benzo[a]pyrene in serum of 199 pregnant women (68 with PL and 81 with normal delivery) with the following analysis of associations between progestagen administration and these parameters.Results. The level of IgA to estradiol in patients with preterm labor was significantly higher than in women with normal delivery, and the administration of progestagens did not reduce their level in women with preterm birth.Conclusions. Measurement of the antibodies to estradiol may help in predicting pregnancy complications such as preterm birth.

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Clinicopathological parallelism in placental microbial colonization

Марочко

Леванова

Kolesnikova

et al. 2019

Fundamentalʹnaâ i kliničeskaâ medicina

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Aim. To study the course of pregnancy, childbirth and the postpartum period in pregnant women with placental microbial colonization; to investigate placental morphology during the microbial colonization.Materials and Methods. We retrospectively investigated 128 case histories of the pregnant women with or without (n = 64) placental microbial colonization.Results. Enterobacteriaceae spp., Enterococcaceae spp. and Staphylococcaceae spp. were respectively isolated from placentas of 24 (37.5%), 19 (29.7%), and 19 (29.7%) women with placental microbial colonization. Candida albicans was isolated in 2 (3.1%) cases. All placentas excised from women without placental microbial colonization were sterile. Vaginal delivery occurred in 61 (95.3%) women with placental microbial colonization but only in 24 (37.5%) women without (p = 0.001). Subinvolution was revealed in 10 (15.6%) and 4 (6.3%) (р = 0.09), lochiometra was found in 4 (6.3%) and 2 (3.1%) (р = 0.409), and wound infections were observed in 5 (7.8%) and 1 (1.6%) (p = 0.095) women with or without placental microbial colonization, respectively. Therefore, prevalence of postpartum complications did not differ significantly between the groups. Placental inflammation was detected in 27(42.2%) and 14 (21.9%) (p = 0.014) patients with or without placental microbial colonization, respectively.Conclusions. Placental inflammation is associated with microbial colonization which is more common in women who undergo vaginal delivery.

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Endometriosis and cancerogenesis of the ovaries (a review)

Cited by 3 publications

References 30 publications

The role of ARID1A in malignant neoplasms of the female reproductive system: a modern view on the possibilities of diagnosis and therapy

The role of ARID1A in malignant neoplasms of the female reproductive system: a modern view on the possibilities of diagnosis and therapy

The effect of progestagens on immunological risk factors of preterm birth

Clinicopathological parallelism in placental microbial colonization

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