Endometriosis and dysbiosis: State of art

Zizolfi, Brunella; Foreste, Virginia; Martone, Simona; Giampaolino, Peirluigi; Sardo, Attilio Di Spiezio

doi:10.3389/fendo.2023.1140774

Cited by 17 publications

(17 citation statements)

References 67 publications

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“…141 Dysbiosis could stimulate immune cells, leading to the production of pro-inflammatory factors that contribute to the growth and persistence of endometriotic lesions. 131…”

Section: Wate R Pol Lu Tion a N D E N Dom Etr Iosismentioning

confidence: 99%

“…130 In summary, water pollution, particularly due to chemical contaminants and heavy metals, could play a role in the development and progression of endometriosis. 131 Thus, the connection between water pollution and endometriosis underscores the importance of effective environmental regulations, sustainable practices, and individual efforts to mitigate its potential impact on women's reproductive health (Figure 1).…”

Section: Wate R Pol Lu Tion a N D E N Dom Etr Iosismentioning

confidence: 99%

“…140 Dysregulation of the microbiome may impair the metabolism of estrogen, leading to an increase in circulating estrogen levels followed by enhanced endometrial growth and the initiation of endometriotic lesions. 131,136 Moreover, the gut microbiota may interact with the immune system and thus influence immune responses and inflammatory pathways. 141 Dysbiosis could stimulate immune cells, leading to the production of pro-inflammatory factors that contribute to the growth and persistence of endometriotic lesions.…”

Section: Wate R Pol Lu Tion a N D E N Dom Etr Iosismentioning

confidence: 99%

“…The gut microbiome may have a major role in the metabolism and elimination of hormones, such as estrogen 140 . Dysregulation of the microbiome may impair the metabolism of estrogen, leading to an increase in circulating estrogen levels followed by enhanced endometrial growth and the initiation of endometriotic lesions 131,136 . Moreover, the gut microbiota may interact with the immune system and thus influence immune responses and inflammatory pathways 141 .…”

Section: Water Pollution and Endometriosismentioning

confidence: 99%

“…Moreover, the gut microbiota may interact with the immune system and thus influence immune responses and inflammatory pathways 141 . Dysbiosis could stimulate immune cells, leading to the production of pro‐inflammatory factors that contribute to the growth and persistence of endometriotic lesions 131 …”

Section: Water Pollution and Endometriosismentioning

confidence: 99%

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Pollution and endometriosis: A deep dive into the environmental impacts on women's health

Vallée,

Ceccaldi,

Carbonnel

et al. 2023

BJOG

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BackgroundThe interaction between pollution and endometriosis is a pressing issue that demands immediate attention. The impact of pollution, particularly air and water pollution, or occupational hazards, on hormonal disruption and the initiation of endometriosis remains a major issue.ObjectivesThis narrative review aims to delve into the intricate connection between pollution and endometriosis, shedding light on how environmental factors contribute to the onset and severity of this disease and, thus, the possible public health policy implications.DiscussionEndocrine‐disrupting chemicals (EDCs) in pollutants dysregulate the hormonal balance, contributing to the progression of this major gynaecological disorder. Air pollution, specifically PM2.5 and PAHs, has been associated with an increased risk of endometriosis by enhancing chronic inflammation, oxidative stress, and hormonal imbalances. Chemical contaminants in water and work exposures, including heavy metals, dioxins, and PCBs, disrupt the hormonal regulation and potentially contribute to endometriosis. Mitigating the environmental impact of pollution is required to safeguard women’s reproductive health. This requires a comprehensive approach involving stringent environmental regulations, sustainable practices, responsible waste management, research and innovation, public awareness, and collaboration among stakeholders.ConclusionPublic health policies have a major role in addressing the interaction between pollution and endometriosis in a long‐term commitment.

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“…141 Dysbiosis could stimulate immune cells, leading to the production of pro-inflammatory factors that contribute to the growth and persistence of endometriotic lesions. 131…”

Section: Wate R Pol Lu Tion a N D E N Dom Etr Iosismentioning

confidence: 99%

Section: Wate R Pol Lu Tion a N D E N Dom Etr Iosismentioning

confidence: 99%

Section: Wate R Pol Lu Tion a N D E N Dom Etr Iosismentioning

confidence: 99%

Section: Water Pollution and Endometriosismentioning

confidence: 99%

Section: Water Pollution and Endometriosismentioning

confidence: 99%

See 3 more Smart Citations

Pollution and endometriosis: A deep dive into the environmental impacts on women's health

Vallée,

Ceccaldi,

Carbonnel

et al. 2023

BJOG

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Beyond the reproductive tract: gut microbiome and its influence on gynecological health

Pérez-Prieto,

Rodríguez-Santisteban,

Altmäe

2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review The analysis of microbiome in association with female health is today a “hot topic” with the main focus on microbes in the female reproductive tract. Nevertheless, recent studies are providing novel information of the possible influence of the gut microbiome on gynecological health outcomes, especially as we start to understand that the gut microbiome is an extended endocrine organ influencing female hormonal levels. This review summarizes the current knowledge of the gut microbes in association with gynecological health. Recent findings The gut microbiome has been associated with endometriosis, polycystic ovary syndrome, gynecological cancers, and infertility, although there is a lack of consistency and consensus among studies due to different study designs and protocols used, and the studies in general are underpowered. Summary The interconnection between the gut microbiome and reproductive health is complex and further research is warranted. The current knowledge in the field emphasizes the link between the microbiome and gynecological health outcomes, with high potential for novel diagnostic and treatment tools via modulation of the microenvironment.

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Postmenopausal endometriosis: a challenging condition beyond menopause

Vallée,

Carbonnel,

Ceccaldi

et al. 2024

Menopause

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Importance and Objective Postmenopausal endometriosis is a complex condition that challenges the conventional belief that endometriosis resolves with menopause. Despite the cessation of menstruation, a subset of women continues to experience or develop endometriosis-related symptoms during the postmenopausal period. Thus, this review aimed to shed light on postmenopausal endometriosis, exploring its clinical features, diagnostic considerations, management approaches, and the potential impact on women's health. Methods PubMed/Medline, Scopus, and Web of Science databases were used for the research, with only articles in English language, using the following terms: “postmenopausal endometriosis,” “menopause,” “management,” “treatment,” and “quality of life,” from inception to 2023. Discussion and Conclusion The clinical features of postmenopausal endometriosis include persistent or recurrent pelvic pain, dyspareunia, bowel, or urinary symptoms and, occasionally, abnormal vaginal bleeding. The absence of menstrual cycles presents a diagnostic challenge, as the traditional diagnostic criteria for endometriosis rely on menstrual patterns. Visual cues may be less evident, and the symptoms often overlap with other gynecological conditions, necessitating a thorough evaluation to differentiate postmenopausal endometriosis from other potential causes. Management approaches for postmenopausal endometriosis encompass surgical intervention, hormonal therapies, pain management, and individualized care. Postmenopausal endometriosis significantly impacts the quality of life, sexual health, and long-term well-being of women. Understanding the clinical features, diagnostic challenges, and management approaches of postmenopausal endometriosis is crucial for healthcare professionals to provide effective care and to improve the quality of life of women affected by this condition.

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Endometriosis and dysbiosis: State of art

Cited by 17 publications

References 67 publications

Pollution and endometriosis: A deep dive into the environmental impacts on women's health

Pollution and endometriosis: A deep dive into the environmental impacts on women's health

Beyond the reproductive tract: gut microbiome and its influence on gynecological health

Postmenopausal endometriosis: a challenging condition beyond menopause

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