Endometriosis and Infertility: How and When to Treat?

Fadhlaoui, Anis; Joliniere, J. Bouquet De; Féki, Anis

doi:10.3389/fsurg.2014.00024

Cited by 48 publications

(53 citation statements)

References 58 publications

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“…Patient-derived endometrial organoids can also be exploited for modeling endometriosis, a disease that affects between 10 and 15% of all women of reproductive age and 70% of women with chronic pelvic pain (Giudice and Kao, 2004;Vercellini et al, 2013). When one considers that there is no curative solution for endometriosis (Fadhlaoui et al, 2014), it is hoped that endometrial organoids may help to accelerate the development of novel therapeutics in this area of research.…”

Section: Advantages and Applications Of Endometrial Organoidsmentioning

confidence: 99%

Organoid Models of Human Endometrial Development and Disease

Hibaoui

Féki

2020

Front. Cell Dev. Biol.

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Section: Advantages and Applications Of Endometrial Organoidsmentioning

confidence: 99%

Organoid Models of Human Endometrial Development and Disease

Hibaoui

Féki

2020

Front. Cell Dev. Biol.

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“…Recent reports have indicated that infertility was due to the presence of endometriosis for 20-50% of infertile couples [3][4][5], and endometriosisrelated infertility has become a common finding among infertility patients. Infertility patients with endometriosis are treated in accordance with the clinical ESHRE guidelines [4] or expert opinion [6]. Although these guidelines were established based on the literature data, such as the Cochrane review [7], they fail to describe the duration between surgical treatment for endometriosis and the establishment of the first pregnancy.…”

Section: Introductionmentioning

confidence: 99%

The Endometriosis Fertility Index Is Useful for Predicting the Ability to Conceive without Assisted Reproductive Technology Treatment after Laparoscopic Surgery, Regardless of Endometriosis

Rutsuko¹,

Nakagawa²,

Usui³

et al. 2017

Gynecol Obstet Invest

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Objective: The endometriosis fertility index (EFI) is a novel index for predicting pregnancy after surgery. We investigated the utility of the EFI for predicting the ability to conceive without assisted reproductive technology (ART) treatment after laparoscopic surgery. Methods: From July 2011 through December 2012, we recruited 133 infertile patients who underwent laparoscopy, and the EFI was calculated. After surgery, 55 of 133 achieved pregnancy without ART treatment. We evaluated the factors that predicted a naturally successful pregnancy and compared them between the pregnant and non-pregnant subjects. Results: On a univariate linear regression analysis, we found that a younger age, shorter duration of infertility, and higher EFI were positively associated with a successful pregnancy without ART after laparoscopic surgery (p < 0.05). According to 50th percentile EFI, the cutoff EFI predicting a successful pregnancy without ART was 7, the pregnancy rate in the high-EFI group (EFI; 8-10) was significantly higher than that in the low-EFI group (EFI ≤7; p < 0.05), but the duration to natural conception after surgery was similar between the 2 groups. Conclusion: The EFI possesses greater predictive power for a successful pregnancy with natural intercourse or intrauterine insemination in infertile patients, regardless of endometriosis, than the Revised-American Society of Reproductive Medicine classification.

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“…Endometriosis is a complex and multifactorial disease and its etiology and pathogenesis have not yet been completely clarified [8].…”

Section: Pathogenesismentioning

confidence: 99%

Endometriosis: When and How We Treat

Saceanu¹,

Pătrașcu²,

Pătraşcu³

et al. 2017

Fertility-Oriented Female Reproductive Surgery

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Endometriosis is a chronic, nonmalignant and estrogen-dependent disease in which endometrial glandular epithelium and stroma are outside the uterine cavity (ovaries, peritoneum, or rectovaginal septum). The prevalence is estimated from 2 to 10% in women of childbearing age and it rises up to 50% in women with infertility. Despite maximal efforts, the therapy of first choice in the management of endometriosis is still unclear. The aim of this chapter is to present an update of its management, emphasizing the benefits and disadvantages of surgical methods. We performed a systematic literature search on the PubMed database of English literature (search terms: endometrioma, surgery, ovarian reserve, assisted reproductive technologies) from 2010 to 2014. For endometrioma, operative laparoscopy proved to be the gold standard. Surgical procedures consist of partial excision of the cyst wall and electro-coagulation of the rest. Stripping technique may be a better method for reducing the recurrence of pain symptoms, recurrence, and reoperation rates, but it raises concerns about ovarian reserve. For endometriosis, surgery often includes partial rectum or sacrouterine ligament resection. Hysterectomy is not obligatory and refused by the young patients. The approach should be laparoscopic and if necessary vaginal assisted. Good cooperation between various disciplines (gynecology, surgery, urology) is mandatory.

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Endometriosis and Infertility: How and When to Treat?

Cited by 48 publications

References 58 publications

Organoid Models of Human Endometrial Development and Disease

Organoid Models of Human Endometrial Development and Disease

The Endometriosis Fertility Index Is Useful for Predicting the Ability to Conceive without Assisted Reproductive Technology Treatment after Laparoscopic Surgery, Regardless of Endometriosis

Endometriosis: When and How We Treat

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