Endometriosis and Ovulatory Disorder: Reduced Fertilisation in Vitro Compared With Tubal and Unexplained Infertility

Wardle, Peter G.; McLaughlin, Eileen A.; McDermott, Alan; Mitchell, J.D.; Ray, B.D.; Hull, M. G. R.

doi:10.1016/s0140-6736(85)90289-2

Cited by 165 publications

(73 citation statements)

References 17 publications

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“…Several studies reported a reduced fertilization rate with IVF in women with endometriosis [2,[8][9][10][11][12][13][14]. Pal et al (1998) reported a significant reduction in fertilization rates in stage III and IV of endometriosis compared with stage I and II.…”

Section: Introductionmentioning

confidence: 99%

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Komsky-Elbaz

Raziel

Friedler

et al. 2012

J Assist Reprod Genet

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Purpose This study compares the fertilization rate and embryonic development of oocytes randomly inseminated by conventional IVF or ICSI in patients with endometriosis and normozoospermic semen during IVF cycles. Methods Sibling oocytes were randomized to be inseminated either by ICSI or IVF. Rates of fertilization, cleavage, blastulation and embryonic morphology were assessed. Results A total of 786 sibling cumulus-oocyte complexes (COC) were randomized between insemination by conventional IVF (387 COC) or ICSI (399 COC). A significantly higher fertilization rate was found in the ICSI group (ICSI versus IVF, 73.3±23 % versus 54.7±31.9 % respectively; P=0.003), yielding a higher mean number of day 2 embryos (5.2±3.4 versus 3.6±2.9 respectively; P=0.002). Triploid fertilization rate (3PN/COC) was significantly higher in the IVF group compared to the ICSI group (3.9±8.7 % versus 0.9±3.1 % respectively; P=0.02). The morphology score and rate of development of day 2 and 3 embryos were not different between the two groups. Comparison of embryo transfer cycles in which either IVF or ICSI only embryos were transferred did not reveal any statistically significant differences in pregnancy or implantation rates.Conclusion ICSI appears to be a better treatment option than conventional IVF in endometriosis-associated infertility, since it offers the advantages of higher fertilization rate and mean number of embryos and lower rate of total fertilization failure and triploid fertilization.

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Section: Introductionmentioning

confidence: 99%

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Komsky-Elbaz

Raziel

Friedler

et al. 2012

J Assist Reprod Genet

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show abstract

“…From in-vitro fertilization studies conflicting data have been reported on the fertilization of ova recovered in endometriosis patients. Normal fertilization rates have been found in patients with mild endome¬ triosis (Chillik et al, 1985;O'Shea et al, 1985;Matson & Yovich, 1986), but Wardle et al (1985) have shown that even mild endometriosis affects the quality of oocytes and reduces the fertilization rate. In our model of mild endometriosis the fertilization rates of rabbits in the experimental group were not different from those in the control group.…”

Section: Resultsmentioning

confidence: 99%

“…The reasons for this decreased fecundity, in particular when Fallopian tubes and ovaries are free of adhesions, remain unclear. Disturbances in folliculogenesis (Rönnberg et al, 1984;Wardle et al, 1985), ovulation (Soûles et al, 1976;Brosens et al, 1978;Lesorgen et al, 1984), ovum pickup by the Fallopian tubes (Werlin et al, 1984;Suginami et al, 1986), fertilization (Wardle et al, 1985) and implantation (Chillik et al, 1985) all have been suggested as a cause. Changes in the peritoneal milieu secondary to endometrial implants might cause these disturbances.…”

Section: Introductionmentioning

confidence: 99%

Effect of endometriosis on ovulation, ovum pickup, fertilization and tubal transport in the rabbit

Dunselman

Land²,

Bouckaert³

et al. 1988

Reproduction

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Summary. In 25 rabbits (Group E) endometrium from the right uterine horn was transplanted onto the peritoneum. In 25 rabbits (Group C) fat was transplanted. After a recovery period of 12 weeks the does were mated, and killed 24 h later. In Group E the implants had changed into cysts of 5\p=n-\15mm in diameter. Histological examination revealed endometrial glands and stroma in every specimen. Periadenexal adhesions did not develop in any animal. No differences were found between Groups C and E in the number of corpora lutea, the recovery rate, the fertilization rate and the transport of fertilized ova. These findings indicate that endometrial implants in the rabbit have no influence on the ovulatory mechanism, the pickup function of the oviduct, the fertilization rate or on the transport of fertilized ova. Taking into account the restrictions of a rabbit model, it is suggested that the decreased fecundity in mild endometriosis in the human may be caused by disturbances in post-fertilization events, i.e. development of the pre-implantation embryo or implantation.

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“…The effect of .endometriosis on IVF outcome is controversial (13,14). A low fertilization rate probably related to ovulatory disorders, an altered follicular response because of disruption of ovarian blood supply or mechanical pressure, an alteration of oocyte quality resulting in a reduced implantation rate, and, finally, a toxic effect of human serum have been considered responsible for a poor outcome in IVF cycles (13,(15)(16)(17)(18). In contrast, recent reports have concluded that, regardless of its stage, endometriosis does not affect the outcome of IVF treatment (14,(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Is there any need for diagnostic laparoscopy in couples undergoing intracytoplasmic sperm injection for severe male-factor infertility?

Aytoz¹,

Tournaye²,

Camus³

et al. 1998

J Assist Reprod Genet

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Endometriosis and Ovulatory Disorder: Reduced Fertilisation in Vitro Compared With Tubal and Unexplained Infertility

Cited by 165 publications

References 17 publications

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Effect of endometriosis on ovulation, ovum pickup, fertilization and tubal transport in the rabbit

Is there any need for diagnostic laparoscopy in couples undergoing intracytoplasmic sperm injection for severe male-factor infertility?

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