Endometriosis and risk of ovarian cancer

Kornovski, Yavor; Atanasova, Yonka; Kostov, Stoyan; Slavchev, Stanislav; Yordanov, Angel

doi:10.5603/ocp.2021.0012

Cited by 2 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The following clinical groups are at an increased risk of developing EAOC: patients aged > 45-50 years; nulliparous patients; long term history of endometriosis; diagnosis in postmenopause; endometriomas ≥ 9 cm; hyperestrogenism. 30 Closer monitoring is advised for this patient population.…”

Section: Discussionmentioning

confidence: 99%

Endometriosis and Ovarian Cancer: Should we be worried? Five Cases Report and Literature Review

Silva Pereira,

Nave,

Magro

2023

Gaz Med

View full text Add to dashboard Cite

Endometriosis is a chronic inflammatory disease caused by the presence of extra-uterine endometrial tissue that affects women of reproductive age. Although the etiology remains not totally elucidated, recent advances in molecular technology, especially the ability for whole genome sequencing, have gradually revealed both genetic and epigenetic backgrounds for the development of the disease. Endometriosis has been recognized as a precursor lesion for certain types of ovarian cancer (endometriosis-associated ovarian cancers - EAOC) and the knowledge of this malignant potential is of paramount importance to seek for predictive factors and to select patients at risk. We report five different EAOC cases in our recent clinical practice, in order to draw attention to this issue through a literature review, and to provide clinicians with tools to communicate accurately and effectively with patients with endometriosis about their risk of ovarian cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Endometriosis and Ovarian Cancer: Should we be worried? Five Cases Report and Literature Review

Silva Pereira,

Nave,

Magro

2023

Gaz Med

View full text Add to dashboard Cite

show abstract

“…The pathological mechanism of the formation of a neoplastic lesion from an endometriosis focus is complex and includes oxidative stress, inflammatory processes, estrogen effects (hyperestrogenism), hemorrhages, and somatic mutations in the PIK3CA, PTEN, and ARID1A genes. 5,[55][56][57] In general, patients with EAOC have a good prognosis as long as they are diagnosed early enough. 58 According to a few scientific reports, benign ovarian cysts can be precursors to malignant lesions.…”

Section: Gynecologic and Gynecologic-related Factorsmentioning

confidence: 99%

Utility of Matrix Metalloproteinases in the Diagnosis, Monitoring and Prognosis of Ovarian Cancer Patients

Kicman¹,

Niczyporuk²,

Kulesza³

et al. 2022

CMAR

View full text Add to dashboard Cite

Ovarian cancer is one of the most common gynecologic malignancies. It is characterized by a high mortality rate, which is mainly due to the asymptomatic course of the disease. In light of the high mortality rate and increasing morbidity, new diagnostic methods are being explored to enable earlier detection, better monitoring, and improved prognosis. Such diagnostic methods include the assessment of tumor markers in various biological samples. Among the markers currently being investigated, extracellular matrix metalloproteinases (MMPs) are of particular interest. The objective of this article was to compile the existing knowledge of MMPs in ovarian cancer patients and to describe their potential diagnostic utility. Additionally, this article provides an overview of the symptoms, complications, and risk factors associated with ovarian cancer and the role of MMPs in physiology and pathology. Preliminary results indicate that tissue expression and blood and body fluid levels of MMPs may be different in ovarian cancer patients than in healthy women. The expression and concentration of individual MMPs have been shown to be correlated with cancer stage and disease severity. In addition, the preliminary value of some of these enzymes in predicting prognosis is discussed. However, as the amount of data is limited, more studies are needed to fully evaluate the potential function of individual MMPs in ovarian cancer patients. Based on the knowledge gathered for this article, it seems that MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-13, are tentatively the most useful. A thorough evaluation of their utility as modern biomarkers in ovarian cancer requires further investigation.

show abstract

Endometriosis and risk of ovarian cancer

Cited by 2 publications

References 26 publications

Endometriosis and Ovarian Cancer: Should we be worried? Five Cases Report and Literature Review

Endometriosis and Ovarian Cancer: Should we be worried? Five Cases Report and Literature Review

Utility of Matrix Metalloproteinases in the Diagnosis, Monitoring and Prognosis of Ovarian Cancer Patients

Contact Info

Product

Resources

About