Endometriosis and Systemic Lupus Erythematosus: Systematic Review and Meta-analysis

Ferrari‐Souza, João Pedro; Pedrotti, Mirela Tschiedel; Moretto, Enrico Emerim; Farenzena, Laura Penso; Crippa, Luís Guilherme; Cunha-Filho, J.S.

doi:10.1007/s43032-022-01045-3

Cited by 3 publications

(1 citation statement)

References 58 publications

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“…Immunocompetent cells, such as neutrophils and macrophages, are present in endometriosis tissue, which is closely associated with the development of endometriosis (Hogg et al 2020;Symons et al 2020;Xu et al 2020). Endometriosis has not yet been proven as an autoimmune disease, but it is associated with an altered immune system and linked to several autoimmune diseases (Nothnick 2001;Ferrari-Souza et al 2022). Endometriosis is similar to autoimmune diseases because immune cells are present and chronic inflammation is induced in a specific tissue (Martinez et al 2007), which is known to activate neutrophils (Borish et al 1989).…”

Section: A C C E P T E Dmentioning

confidence: 99%

Exploratory Study of Serum Lactoferrin and Anti-Lactoferrin Antibody Concentrations in Patients with Endometriosis

Mori-Yamanaka

Kimura

Nakamura

et al. 2023

Tohoku J. Exp. Med.

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Endometriosis is a disease that is characterized by the ectopic presence of the endometrium or its similar cells. A high prevalence of patients with autoimmune diseases has been reported among patients with endometriosis although the cause of endometriosis remained unknown. Recently, the anti-lactoferrin antibody is reported to be highly detected in autoimmune diseases. This study focused on lactoferrin and antilactoferrin antibodies to explore the pathology of endometriosis. Lactoferrin is a substance that regulates inflammation and is produced by neutrophils. Anti-lactoferrin antibody is a type of perinuclear antineutrophil cytoplasmic antibody. The serum lactoferrin and anti-lactoferrin antibody levels were compared among patients with or without endometriosis, revealing significantly higher levels in patients with endometriosis. Additionally, a decreased serum anti-lactoferrin antibody level was observed after surgical endometriosis resection. The receiver operating characteristic curve analysis determined the reference values for the serum lactoferrin and antilactoferrin antibody levels. Patients whose serum level exceeded the reference antilactoferrin antibody value were significantly higher in more than 40% of cases in the endometriosis group. The rate is comparable to that of autoimmune diseases. This is the first report that anti-lactoferrin antibody is frequently observed in patients with endometriosis, adding a new perspective to the understanding of the pathology of endometriosis although precisely elucidating the mechanism by which lactoferrin and anti-lactoferrin antibody appear in endometriosis in the future is necessary.

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Section: A C C E P T E Dmentioning

confidence: 99%

Exploratory Study of Serum Lactoferrin and Anti-Lactoferrin Antibody Concentrations in Patients with Endometriosis

Mori-Yamanaka

Kimura

Nakamura

et al. 2023

Tohoku J. Exp. Med.

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Effect of Dietary Interventions on Endometriosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meneghetti,

Pedrotti,

Coimbra

et al. 2024

Reprod. Sci.

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Impact of Systemic Lupus Erythematosus on Conception: Insights into Infertility, Fertility Preservation, Assisted Reproductive Technology, and Pregnancy Outcomes

Moyer,

Edens

2024

Semin Reprod Med

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Many individuals with systemic lupus erythematosus (SLE) face significant challenges manifesting their family planning goals due to numerous factors, including disease-related complications, treatment-induced effects, immunological factors, self-imposed limitations, and the socioeconomic impacts of having a chronic disease. Instances of unexplained infertility are also prevalent. Encouragingly, advancements in treatment modalities, risk factor management, specialized training within the medical community, and enhanced patient/provider education have contributed to an increase in successful pregnancies among SLE patients, fostering a safer, more promising reproductive landscape. However, despite advances, individuals with SLE continue to struggle with the complexities of family building. This review explores infertility and pregnancy outcomes in SLE, fertility preservation, the role of assisted reproductive technology, and considerations for tailoring these approaches to SLE patients.

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Endometriosis and Systemic Lupus Erythematosus: Systematic Review and Meta-analysis

Cited by 3 publications

References 58 publications

Exploratory Study of Serum Lactoferrin and Anti-Lactoferrin Antibody Concentrations in Patients with Endometriosis

Exploratory Study of Serum Lactoferrin and Anti-Lactoferrin Antibody Concentrations in Patients with Endometriosis

Effect of Dietary Interventions on Endometriosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Impact of Systemic Lupus Erythematosus on Conception: Insights into Infertility, Fertility Preservation, Assisted Reproductive Technology, and Pregnancy Outcomes

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