Endometriosis and uterine leiomyomata with ovarian granulosa cell tumour

Kurioka, Hiroko; Takahashi, Kentaro; Ueda, T.; Ozaki, Tomoya; Miyazaki, Kohji

doi:10.1093/humrep/13.5.1357

Cited by 7 publications

(6 citation statements)

References 8 publications

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“…In the present study, a 40-year-old women diagnosed clinically with dysfunctional uterine bleeding and leiomyoma when subjected to HPE revealed a coincidental ovarian GCT, simple hyperplastic endometrium, and intramural leiomyoma similar to a case report by Kurioka et al . [ 35 ] Hence, the authors emphasize on imperative submission of all hysterectomy specimens for histopathology, thorough sampling, and diligent quest for associated pathologies in routine hysterectomy specimens, few of which may need further management and surveillance for the patient's well-being.…”

Section: Discussionmentioning

confidence: 99%

Uterine Leiomyomas: An ENIGMA

Geethamala¹,

Murthy²,

Vani³

et al. 2016

J Mid-life Health

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Introduction:Leiomyomas are benign tumors composed of smooth muscle cells and varying amounts of fibrous connective tissue commonly encountered in women of reproductive age group. Leiomyomas need hormonal milieu for their growth and maintenance. Unopposed estrogenic stimulation manifests as leiomyomas undergoing secondary changes, endometrial proliferation or hyperplasia, and other associated pathological findings.Objective:To study and analyze various histopathological changes within uterine leiomyomas in hysterectomy specimens. And also, to analyze the associated endometrial and adnexal structures pathology.Materials and Methods:A 4 years retrospective study from June 2010 to June 2014 conducted in the Department of Pathology and Obstetrics and Gynecology, ESIC Medical College and PGIMSR, wherein 820 hysterectomy specimens clinically diagnosed as uterine leiomyomas were subjected to histopathological examination and relevant clinical data were analyzed.Results:Leiomyomas occurred mostly in women aged 31-50 years (90.23%). Menorrhagia (49.36%) and pain abdomen (30.6%) were the chief clinical manifestations. Endometrial patterns commonly seen were proliferative and hyperplastic endometrium together accounting for 73.4% and dual pathology with adenomyosis was 29.1%. Four cases of tubercular etiology and a single case of granulosa cell tumor of ovary was noted.Conclusion:Though hysterectomy is a routine procedure in the management of uterine leiomyomas, occasional cases of tumor or infective pathology may be missed. Therefore, histopathology is mandatory and conscientious quest must be done for confirmed diagnosis and ensuring optimal management.

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Section: Discussionmentioning

confidence: 99%

Uterine Leiomyomas: An ENIGMA

Geethamala¹,

Murthy²,

Vani³

et al. 2016

J Mid-life Health

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“…[19] There are two case reports of rapid growth of both fibroids and endometriosis, and this has been suggested to be a result of a hyperestrogenic state. [2122] In addition, the role of estrogens is supported by the fact that neither fibroids nor endometriosis appear before the age of onset of fertility, and during the menopause the symptoms of both diseases diminish. [7]…”

Section: Discussionmentioning

confidence: 99%

Do symptomatic endometriosis and uterine fibroids appear together?

Uimari

Järvelä

2011

J Hum Reprod Sci

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OBJECTIVES:Endometriosis and uterine fibroids are common gynecological disorders in fertile women. It has been suggested that these two disorders may be associated with each other. In this study, we tested whether this connection exists. In addition, we wanted to evaluate whether they both affect fertility independently of each other.MATERIALS AND METHODS:The prevalence of endometriosis and uterine fibroids was investigated in three groups of patients: Symptomatic patients requiring surgery either for endometriosis (n=182), or for uterine fibroids (n=240) and asymptomatic patients undergoing laparoscopic sterilization (n=183). The prevalences were examined in three age groups: 35–39 yrs, 40–44 yrs and ≥ 45 yrs. The significance of both diagnoses on fertility was assessed using logistic regression analysis.RESULTS:Uterine fibroids were detected in 25.8% (47/182) of patients with endometriosis. Endometriosis was detected in 19.6% (47/240) of patients with uterine fibroids. 5.5% (10/183) women undergoing sterilization had endometriosis and 19.3% (17/183) had uterine fibroids. Both uterine fibroids and endometriosis were, independently of each other, related to subfertility (OR, 95% CI: 3.8, 2.3–6.5; 6.8, 4.0–11.6, respectively).CONCLUSIONS:The results suggest that symptomatic endometriosis appears together with symptomatic uterine fibroids. Both diseases seem to decrease female fertility independently of each other.

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“…In cases of pelvic endometriosis, Matsushima et al, (2002) found a large number of macrophages using an autosmear method for the tubal collected cells. The etiology of endometriosis and uterine leiomyomata are related to the presence of an estrogen -secreting neoplasm and that the presence of a state of hyperestrogenemia due to granulosa cell tumor over several years might have stimulated the development the endometriosis and leiomyomata (Kurioka et al, 1998). Ferrara et al, (1993) described, in a patient affected by an ovarian granulosa cell tumor (adult type), a case of non-cicatrical endometriosis of the thoracic skin.…”

Section: Discussionmentioning

confidence: 99%

Pathological studies on fallopian tube in relation to uterine lesions and ovarian abnormalities

Mahdy

2010

Journal of Veterinary Medical Research

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A total number of 50 genital tracts were collected from cows slaughtered at "Belefia" abattoir in "Beni-Suef" governorate, Egypt. The genitalia were inspected grossly and the ovarian activity was noticed. Tissue specimens were taken from the tips of uterine horns, fallopian tubes, ovaries of both sides. The fallopian tubes were cut and sampled at three levels namely, infundibulum, ampulla, isthmus. All tissue specimens were fixed in 10% formalin solution, embedded in paraffin wax, sectioned at 5 µm and stained with hematoxylin and eosin stain (Bancroft and Stevens 1996) and examined microscopically. The pathological changes in the fallopian tube in relation to lesions in the uterus and ovarian activity were investigated. The uterine pathological lesions were endometritis (12%), adenomyosis (12%), and cystic glandular hyperplasis (8%). Inflammation of the fallopian tube salpingitis, was graduated as mild degree(18%), moderate degree(2%), and severe degree (2%). The intraepithelial microcysts of the uterine tube represented 8% of the examined cases.

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Endometriosis and uterine leiomyomata with ovarian granulosa cell tumour

Cited by 7 publications

References 8 publications

Uterine Leiomyomas: An ENIGMA

Uterine Leiomyomas: An ENIGMA

Do symptomatic endometriosis and uterine fibroids appear together?

Pathological studies on fallopian tube in relation to uterine lesions and ovarian abnormalities

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