Endometriosis‐Associated Infertility: Double Intrauterine Insemination Improves Fecundity in Patients Positive for Antiendometrial Antibodies

Subit, Michael; Gantt, Pickens A.; Broce, Mike; Seybold, Dara; Randall, Gary W.

doi:10.1111/j.1600-0897.2010.00973.x

Cited by 6 publications

(6 citation statements)

References 56 publications

(102 reference statements)

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“…Subit in a study of 1243 patients found double IUI to be significantly better in patient with endometriosis and antiendometrial antibodies. 12 The study recommends double iui before resorting to more invasive and expensive treatment options. Timing of performing double IUI has been debated.…”

Section: Discussionmentioning

confidence: 99%

Single versus double intrauterine insemination to assess the relevance of double intrauterine insemination: a prospective, randomized multicentric study

Patil

2021

Int J Reprod Contracept Obstet Gynecol

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Background: Intrauterine insemination (IUI) is a widely used tool as initial treatment option for infertile couples. Being a non-invasive, outpatient department (OPD) based procedure it serves as first modality of assisted reproductive technique. Overtime various modifications in stimulation protocol, sperm preparation techniques and variation in timing has been attempted to improve upon the success rates.Methods: We conducted a multicentric, prospective randomized study and assessment of data of double IUI at three tertiary care centers of armed forces. The data was evaluated to study the patient parameters and various factors affecting the success rate of IUI.Results: We found that duration of infertility, age of couple and body mass index (BMI) are inversely related to success of IUI cycles. Double IUI increases the success rate in borderline male factor infertility, ladies with normal BMI and in cases of secondary infertility with previous live issue. In donor IUI cycles there is a positive correlation with sperm parameters and benefit from double insemination.Conclusions: Double IUI can be offered to selected couples to improve upon the success rate of IUI cycle.

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Section: Discussionmentioning

confidence: 99%

Single versus double intrauterine insemination to assess the relevance of double intrauterine insemination: a prospective, randomized multicentric study

Patil

2021

Int J Reprod Contracept Obstet Gynecol

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“…Subit and co‐workers reported the presence of AEA in the sera of women with endometriosis affected fecundity and thus affected the success of an IUI cycle. They further reported lower clinical pregnancy rates in women with endometriosis and there was five times increased clinical pregnancy in women with double IUI cycle 93 . AEAs have also been reported to be associated with higher miscarriage rates 94 .…”

Section: Role Of Anti‐endometrial Antibodies (Aeas) In Female Inferti...mentioning

confidence: 92%

Endometriosis and inflammatory immune responses: Indian experience

Gajbhiye

2022

American J Rep Immunol

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Endometriosis is a public health disorder affecting ∼ 247 million women globally and ∼ 42 million women in India. Women with endometriosis suffer from dysmenorrhea, chronic pelvic pain, dyspareunia, dyschezia, fatigue, depression, and infertility leading to significant socioeconomic impact and morbidity. The etiology of endometriosis is not understood well even after 100 years of research. Currently, there is no permanent cure for endometriosis. The inflammatory immune response is one of the important features of etiopathogenesis of endometriosis and therefore understanding the inflammatory immune response would lead to a better understanding of this enigmatic disorder and may also lead to biomarker discovery for diagnosis of endometriosis.We investigated the autoimmune etiology of endometriosis in the Indian population.Using the proteomics approach, anti-endometrial antibodies (AEAs) were detected in Indian women with endometriosis [anti-endometrial antibodies -tropomyosin 3 (TPM3), stomatin-like protein2 (SLP-2), and tropomodulin 3 (TMOD3)]. The studies on AEAs provided a better understanding of autoimmune mechanisms in endometriosis. All three subtypes of endometriosis; superficial peritoneal, ovarian endometrioma, and deep infiltrating endometriosis were reported in Indian women. In this review, we discuss our experiences of the inflammatory immune response, autoimmunity, comorbidities, and clinical phenotypes in women with endometriosis in India.

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“…Nine studies were identified affecting the reproductive system and possibly altering the possibilities for a successful IVF cycle [82,83,84,85,86,87,88,89,90]. Four of the aforementioned studies concerned ASA [87,89,90,91], 3 AEA [83,86,88], one AGA [82] and one aLN1 in the follicular fluid of women with endometriosis [85]. Although ALN1 is not classified as a reproductive-specific antibody, the study population is diagnosed with endometriosis, a conditioned that has been associated to aLN1 [92].…”

Section: Auto-antibodies Specifically Affecting the Reproductive Smentioning

confidence: 99%

“…According to the results of that study, IVF outcome may be negatively correlated with certain subtypes of AEA. Examining another perspective, the presence of AEA in the sera of female patients may impede their fecundity and the success of an IUI cycle [83]. In all three groups (with endometriosis, without endometriosis, and without laparoscopic investigation) of the study, women diagnosed as AEA positive were associated with a lower CP rate.…”

Section: Auto-antibodies Specifically Affecting the Reproductive Smentioning

confidence: 99%

The Impact of Autoantibodies on IVF Treatment and Outcome: A Systematic Review

Simopoulou

Sfakianoudis²,

Maziotis

et al. 2019

IJMS

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The role of autoantibodies in in vitro fertilization (IVF) has been discussed for almost three decades. Nonetheless, studies are still scarce and widely controversial. The aim of this study is to provide a comprehensive systematic review on the possible complications associated to autoantibodies (AA) impeding the chances of a successful IVF cycle. An Embase, PubMed/Medline and Cochrane Central Database search was performed on 1 December 2018, from 2006 until that date. From the 598 articles yielded in the search only 44 relevant articles ultimately fulfilled the inclusion criteria and were qualitatively analyzed. Five subsets of results were identified, namely, thyroid related AA, anti-phospholipid antibodies, anti-nuclear antibodies, AA affecting the reproductive system and AA related to celiac disease. It may be implied that the majority of auto-antibodies exert a statistically significant effect on miscarriage rates, whereas the effects on clinical pregnancy and live birth rates differ according to the type of auto-antibodies. While significant research is performed in the field, the quality of evidence provided is still low. The conduction of well-designed prospective cohort studies is an absolute necessity in order to define the impact of the different types of autoantibodies on IVF outcome.

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Endometriosis‐Associated Infertility: Double Intrauterine Insemination Improves Fecundity in Patients Positive for Antiendometrial Antibodies

Abstract: Double IUI improves fecundity in AEA+ patients. E-associated infertility is better diagnosed by the AEA assay than by surgery. Double IUI should be attempted prior to assisted reproductive technologies in AEA+ patients with normal fallopian tubes.

Cited by 6 publications

References 56 publications

Single versus double intrauterine insemination to assess the relevance of double intrauterine insemination: a prospective, randomized multicentric study

Single versus double intrauterine insemination to assess the relevance of double intrauterine insemination: a prospective, randomized multicentric study

Endometriosis and inflammatory immune responses: Indian experience

The Impact of Autoantibodies on IVF Treatment and Outcome: A Systematic Review

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