Endometriosis-associated nerve fibers, peritoneal fluid cytokine concentrations, and pain in endometriotic lesions from different locations

McKinnon, Brett; Bersinger, Nick A.; Wotzkow, Carlos; Mueller, Michael D.

doi:10.1016/j.fertnstert.2011.11.011

Cited by 108 publications

(81 citation statements)

References 30 publications

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“…The immunohistochemistry results of this study indicate that GLUT3 expression was also primarily in the CD45-positive leukocytes that infiltrate the endometriotic lesions, as well as the surrounding large nerve fiber trunks in the ectopic tissue. Increased numbers of immune cells have been detected in endometriotic lesions (Halme et al 1983), and nerve fibers are found proximal to lesions, particularly in the peritoneal cavity and the RVS (Mechsner et al 2007, McKinnon et al 2012. It is hence possible that the increase in SLC2A3 expression observed in this study is derived from the increased infiltration of leukocytes and nerve fibers and therefore that GLUT3 may not contribute substantially to the glucose requirements of the ectopic tissue.…”

Section: Discussionmentioning

confidence: 65%

Glucose transporter expression in eutopic endometrial tissue and ectopic endometriotic lesions

McKinnon¹,

Bertschi²,

Wotzkow³

et al. 2014

Journal of Molecular Endocrinology

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Endometriosis is an extremely prevalent disorder characterized by the growth of endometrial tissue at ectopic locations. Glycolysis is an energy-producing mechanism that occurs in almost all cells and requires an adequate uptake of glucose mediated by glucose transporter (GLUT) proteins. At present, however, very little is known about their expression in either the endometrium or the endometriotic lesions. The objective of this study was to examine the expression of SLC2A genes in the endometrium of women with and without endometriosis and in the matching ectopic tissue, and to confirm the presence of the GLUT proteins in ectopic lesions. There was a significantly higher expression of SLC2A3 and a significantly lower expression of SLC2A4 in women with endometriosis compared with those without. In women with endometriosis, the ectopic expression of SLC2A3, SLC2A4 and SLC2A5 was significantly higher than that observed in the matching eutopic tissue. GLUT1 protein expression was present in both epithelial and stromal cells and GLUT3 was confined to CD45-positive leukocytes. GLUT4 expression was strong in both ectopic epithelial and stromal cells and localized to the cellular membrane in epithelial cells. These results show that GLUT expression is altered between eutopic and ectopic tissue and between women with and without endometriosis, and that GLUT4 may represent a significant entry route for glucose into the endometriotic epithelial cells. The inducible nature of GLUT4 and its limited cellular expression may make GLUT4 an attractive target for non-hormone-based treatments of endometriosis.

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Section: Discussionmentioning

confidence: 65%

Glucose transporter expression in eutopic endometrial tissue and ectopic endometriotic lesions

McKinnon¹,

Bertschi²,

Wotzkow³

et al. 2014

Journal of Molecular Endocrinology

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“…By contrast, the pan-neuronal protein marker, PGP9.5, was found in only 31.1% of ovarian endometriosis cases, which fell to 19% when no pain was reported [54]. More limited ovarian endometriosis innervation has also been reported [19,55,56]. Possible explanations for these contrasting results could be technical variations in the performance of immunohistochemical analysis, or possible misinterpretation of the spatial relationship between the nerve fibers and the lesions.…”

Section: Endometriotic-associated Nervesmentioning

confidence: 98%

“…A pilot study found that the presence and proximity of nerve fibers is related to the pain experienced with peritoneal lesions [17], and women with peritoneal endometriotic lesions that are associated with nerve fibers are more likely to report higher dysmenorrhea than women with peritoneal lesions that are not associated with nerve fibers [55]. A simple physical interaction, however, is not sufficient to account for all reported pain.…”

Section: Endometriotic-associated Nervesmentioning

confidence: 99%

Inflammation and nerve fiber interaction in endometriotic pain

McKinnon

Bertschi

Bersinger

et al. 2015

Trends in Endocrinology & Metabolism

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130

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“…This was especially true of deep-infiltrating endometriosis [50,53] and, to a lesser extent, peritoneal lesions [54], while it was more controversial in the case of ovarian endometriomas [53][54][55][56].…”

Section: Recurrencementioning

confidence: 99%

“…Moreover, it was shown that this high density was mainly observed in deep lesions located near the intestinal lining. Some studies have suggested a correlation between nerve fiber density and pain in endometriosis patients [53,54]. However, since pain is a suggestive feeling, larger patient populations suffering from different forms of endometriosis should be examined and compared with a disease-free population to conclusively establish a correlation between nerve fiber presence and pain felt by patients.…”

Section: Recurrencementioning

confidence: 99%

Deep rectovaginal endometriotic nodules: perioperative complications from a series of 3,298 patients operated on by the shaving technique

et al. 2012

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The purpose of this study was to analyze complication and recurrence rates after deep endometriotic nodule surgery. A total of 3,298 cases of deep endometriotic nodules were analyzed. The shaving technique was used, avoiding bowel resection. Laparoscopic nodule resection was performed successfully in all cases. Major complications included: (1) rectal perforation in 42 cases (1.3 %), (2) ureteral retention (<5 days) in 21 cases (0.64 %), (3) ureteral injury in 10 cases (0.3 %), and (4) fecal peritonitis in 1 case (0.04 %). This complication rate is much lower than that observed after bowel resection. In the same period, bowel resection was only required in 1.1 % (n 037) of cases. Histology revealed circumscribed nodular aggregates of smooth muscle, endometrial glands, and scanty endometrial stroma. Lesions were found to be invaded by nerve fibers. Endometriosis is not cancer and does not require the same treatment approach. In young women, conservative surgery using the shaving technique means preservation of organs, nerves, and the vascular blood supply. The shaving technique yields low complication and recurrence rates and should be considered the first line in surgical approach in the case of deep endometriotic lesions.

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Endometriosis-associated nerve fibers, peritoneal fluid cytokine concentrations, and pain in endometriotic lesions from different locations

Cited by 108 publications

References 30 publications

Glucose transporter expression in eutopic endometrial tissue and ectopic endometriotic lesions

Glucose transporter expression in eutopic endometrial tissue and ectopic endometriotic lesions

Inflammation and nerve fiber interaction in endometriotic pain

Deep rectovaginal endometriotic nodules: perioperative complications from a series of 3,298 patients operated on by the shaving technique

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