Endometriosis-Associated Ovarian Cancer: Population Characteristics and Prognosis

Barreta, Amilcar; Sarian, Luís Otávio; Ferracini, Amanda Canato; Eloy, Larissa; Brito, Angelo Borsarelli Carvalho; Andrade, L; Derchain, Sophie

doi:10.1097/igc.0000000000001317

Cited by 26 publications

(27 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Relevant articles have reported that approximately 25~80% of patients with EOVC and OCCC also have a diagnosis of endometriosis ( 18 , 19 ). Patients with endometriosis have been reported to be at a 1.49, 3.73 and 2.32 times greater risk of development of OC, OCCC and EOVC respectively, compared with healthy women without endometriosis ( 20 ).…”

Section: Hypothesis Of Eovc Originmentioning

confidence: 99%

“…Recently, an article defined “high-risk” cases as those which share the same mutations present in EOVC and endometriosis, and “low-risk” cases as those not sharing any mutations in endometriosis with the carcinoma ( 30 ). According to the literature, compared with women without endometriosis, women with endometriosis are more likely to be diagnosed with early-stage tumor, with a significantly lower level of serum CA125 before surgery, and are less likely to have lymph node metastasis or to develop platinum resistance disease ( 18 , 31 ). Patients with EOVC arising from endometriosis presented at a lower average age, have a higher percentage of early-stage and lower–grade disease, and are more likely to have no residual disease after primary debulking surgery compared with those without endometriosis, which indicates better survival outcomes ( 32 ).…”

Section: Hypothesis Of Eovc Originmentioning

confidence: 99%

See 1 more Smart Citation

A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

Chen

Qian

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

Ovarian cancer is one of the most common gynecologic cancers that has the highest mortality rate. Endometrioid ovarian cancer, a distinct subtype of epithelial ovarian cancer, is associated with endometriosis and Lynch syndrome, and is often accompanied by synchronous endometrial carcinoma. In recent years, dysbiosis of the microbiota within the female reproductive tract has been suggested to be involved in the pathogenesis of endometrial cancer and ovarian cancer, with some specific pathogens exhibiting oncogenic having been found to contribute to cancer development. It has been shown that dysregulation of the microenvironment and accumulation of mutations are stimulatory factors in the progression of endometrioid ovarian carcinoma. This would be a potential therapeutic target in the future. Simultaneously, multiple studies have demonstrated the role of four molecular subtypes of endometrioid ovarian cancer, which are of particular importance in the prediction of prognosis. This literature review aims to compile the potential mechanisms of endometrioid ovarian cancer, molecular characteristics, and molecular pathological types that could potentially play a role in the prediction of prognosis, and the novel therapeutic strategies, providing some guidance for the stratified management of ovarian cancer.

show abstract

Section: Hypothesis Of Eovc Originmentioning

confidence: 99%

Section: Hypothesis Of Eovc Originmentioning

confidence: 99%

A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

Chen

Qian

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Use of tumor markers to distinguish endometriosis-related ovarian neoplasms from ovarian endometrioma IntrOdUCtIOn Endometriosis may be associated with a subset of histologic subtypes of ovarian cancer. [1][2][3] Both ovarian clear cell carcinoma and endometrioid carcinoma are often associated with endometriosis, [4][5][6] sharing similar histogenesis and pathogenesis, 7 and are known as endometriosis-associated ovarian cancer. Endometrioid ovarian carcinomas differ from highgrade serous ovarian cancers at the mutational level.…”

mentioning

confidence: 99%

Use of tumor markers to distinguish endometriosis-related ovarian neoplasms from ovarian endometrioma

Shinmura

Yoneyama

Harigane

et al. 2020

Int J Gynecol Cancer

View full text Add to dashboard Cite

ObjectiveOnly few studies have focused on tumor markers used in the preoperative diagnosis of endometriosis-related ovarian neoplasms, and previous studies have only assessed serum CA125 levels. This study investigated the significance of preoperative tumor markers and clinical characteristics in distinguishing endometriosis-related ovarian neoplasms from ovarian endometrioma.MethodsA case-control study was conducted on 283 women who were diagnosed with confirmed pathology with endometriosis-related ovarian neoplasms (n=21) and ovarian endometrioma (n=262) at a single institution from April 2008 to April 2018. The serum CA125, CA19–9, carcinoembryogenic antigen (CEA), sialyl Lewis-x antigen (SLX), and lactate dehydrogenase (LDH) levels, age, tumor size, and the presence of mural nodule of the patients were analyzed.ResultsPatients with endometriosis-related ovarian neoplasms were more likely to be older (48 (range, 26–81) vs 39 (range, 22–68) years, P<0.001), have higher levels of CA19–9 (42 vs 19 U/mL, P=0.013), CEA (1.3 vs 0.84 ng/mL, P=0.007), SLX (41 vs 33 U/mL, P=0.050), and LDH (189 vs 166 U/mL, P<0.001) and larger tumor size (79 vs 55 mm, P=0.001), and present with mural nodule (85.7 vs 4.5 %, P<0.001) than those with ovarian endometrioma. The CA125 levels did not significantly differ between the two groups. The area under the curve for each factor was as follows: CA19-9 level, 0.672 (95% CI 0.52 to 0.83; P=0.013); CEA level, 0.725 (95% CI 0.58 to 0.87; P=0.007); SLX level, 0.670 (95% CI 0.53 to 0.84; P=0.050); LDH level, 0.800 (95% CI 0.70 to 0.90; P<0.001); age, 0.775 (95% CI 0.65 to 0.90; P<0.001); and tumor size, 0.709 (95% CI 0.56 to 0.86; P=0.001). Age was a better marker than CA19-9, CEA, and SLX levels according to the receiver operating characteristic curve analysis. The optimal cut-off values for age and tumor size were 47 years and 80 mm, respectively.ConclusionsThe assessment of serum CA19–9, CEA, SLX, and LDH levels may be a useful tool in the preoperative evaluation to differentiate between endometriosis-related ovarian neoplasms and ovarian endometrioma.

show abstract

“…Ovarian endometriosis was strongly associated with an increased risk for ovarian cancer. In spite of favorable characteristics of EAOC, the findings indicated that endometriosis did not affect ovarian cancer prognosis after its onset, although a better overall survival was reported, primarily in clear cell carcinoma (30,75,76).…”

Section: Impact Of Endometriosis On the Prognosis Of Ovarian Cancermentioning

confidence: 86%

“…A second revision by an expert pathologist identified another 11 cases with endometrial foci. From the remaining 50 cases after exclusion criteria, 40 cases (80%) were diagnosed as ovarian cancer associated with endometriosis (75).…”

Section: Impact Of Endometriosis On the Prognosis Of Ovarian Cancermentioning

confidence: 99%

Ovarian endometriosis, a precursor of ovarian cancer: Histological aspects, gene expression and microRNA alterations (Review)

et al. 2021

View full text Add to dashboard Cite

Ovarian endometriosis is a frequent chronic gynecological disease with an uncertain evolution regarding its progression or association with ovarian malignant lesions. The present review summarized the histological aspects, gene expression and microRNA (miRNA/miR) alterations associated with ovarian endometriosis and cancer and their possible interaction. The endometriosis-ovarian cancer interaction has been proposed by certain researchers as a single entity. Histological results indicated that endometriosis has been in different circumstances coexisting with ovarian cancer, with reference to endometrioid and clear cell carcinoma. Endometriosis with moderate and severe atypia can influence cell proliferation and architecture, resulting in a possible malignant transformation. Gene expression analysis indicated that the pathologies of both endometriosis and ovarian cancer are characterized by genetic instability from a molecular point of view, as several important genetic mutations, including ARID1A, PI3KCA, PTEN, BRCA1, BRCA2, TP53 and KRAS genes, were identified. miRNA alterations have been implicated in the regulation of gene expression. Common dysregulated miRNAs, such as miR-331, miR-335, miR-891, miR-548, miR-124, miR-148, miR-215, miR-192, miR-337, miR-153, miR-155, miR-144, miR-221 and miR-3688 were extensively investigated in understanding endometriosis and ovarian cancer evolution. From a combined viewpoint including histological aspects, gene expression and miRNA alterations, it is reasonable to speculate that endometriosis is associated with ovarian cancer. Ovarian endometriosis lesions may present a risk for ovarian malignant lesions, which supports a model of endometriosis as a malignant precursor. However, the endometriosis-ovarian cancer association is not widely accepted in the literature and additional studies are required to validate this association.

show abstract

Endometriosis-Associated Ovarian Cancer: Population Characteristics and Prognosis

Cited by 26 publications

References 25 publications

A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer

Use of tumor markers to distinguish endometriosis-related ovarian neoplasms from ovarian endometrioma

Ovarian endometriosis, a precursor of ovarian cancer: Histological aspects, gene expression and microRNA alterations (Review)

Contact Info

Product

Resources

About