Endometriosis from thelarche to midteens: pathogenesis and prognosis, prevention and pedagogy

Batt, Ronald E.; Mitwally, M.F.

doi:10.1016/j.jpag.2003.09.008

Cited by 78 publications

(43 citation statements)

References 91 publications

(106 reference statements)

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“…This result needs to be systematically studied in larger comparative trials. Furthermore, it has been suggested ''diagnostic laparoscopy in adolescents should be undertaken only by gynecologists skilled in advanced laparoscopic surgical techniques'' (27).…”

Section: Discussionmentioning

confidence: 99%

Complete laparoscopic excision of endometriosis in teenagers: is postoperative hormonal suppression necessary?

Yeung

Sinervo²,

Winer³

et al. 2011

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

Complete laparoscopic excision of endometriosis in teenagers: is postoperative hormonal suppression necessary?

Yeung

Sinervo²,

Winer³

et al. 2011

Fertility and Sterility

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“…In some studies higher levels of estradiol 36,37 and estrone 37 have been observed among adult women who had early age at menarche. Evidence shows that estradiol plays an important role in the development of endometriosis, [38][39][40] which may explain that higher early exposure to estrogen caused by early age at menarche may cause an increased risk for endometriosis.…”

Section: Findings and Interpretationmentioning

confidence: 99%

Reproductive and Lifestyle Factors Associated with Endometriosis in a Large Cross-Sectional Population Sample

Saha

Kuja‐Halkola

Tornvall

et al. 2017

Journal of Women's Health

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Objectives: Despite the high prevalence of endometriosis among women of reproductive age, risk factors or markers for developing the condition remain largely unknown. Many of the published studies are based on small selected samples. We therefore investigated the relationships of reproductive and lifestyle factors with endometriosis in a large sample of Swedish female twins. Material and methods: This cross-sectional study included 28,822 women. Among these, endometriosis was reported by 1,228 women and the self-reported diagnosis was confirmed by medical records. Potential risk factors or markers for risk considered were age at menarche, level of education, body mass index (BMI), parity, oral contraceptive (OC) use, infertility, coffee consumption, smoking, and alcohol intake, which were investigated using logistic regression with crude and adjusted analyses. We performed within-pair analysis to examine the sensitivity of the results. Results: Late age at menarche and higher parity showed an inverse association and infertility showed a strong association with endometriosis. We observed positive associations with coffee consumption and smoking and an inverse association with OC use in crude analysis but not in adjusted analysis. There were no significant associations between level of education, BMI, or alcohol intake and endometriosis. Within-pair analysis showed persistent inverse association of parity and association of infertility with endometriosis. Conclusions: Our study suggests that late age at menarche and higher parity are inversely associated and infertility is strongly associated with endometriosis. Future studies are needed to explore the significance of these factors in the diagnosis of endometriosis and understanding of its etiology.

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“…Blood stasis and retrograde menstruation of the obstructive syndrome may also lead to blood drainage into the peritoneal cavity (hemoperitoneum) as in Figure 1 D. All these findings were evidenced in this study, with the main clinical manifestation being the occurrence of pelvic pain and dysmenorrhea. The intermittent retrograde blood flow seen in this type of syndrome may influence the development of pelvic endometriosis and bring severe subsequent consequences including fertility reduction (Batt & Mitwally, 2003;Sanfilippo et al, 1986;Hur et al, 2007;Singh et al, 2009). While reviewing the literature on 102 superficial malformations (Zurawin et al, 2004;Haddad et al, 1999), an asymmetric distribution between affected and unaffected sides of the body was observed -right hemibody involvement was seen in 57/102 of the cases, while left hemibody anomalies were reported in 37/102 of the subjects; the distribution was equitable in the remaining six cases reported.…”

Section: Discussionmentioning

confidence: 99%

Uterus Didelphys with Obstructed Hemivagina and Ipsilateral Renal Agenesis (OHVIRA Syndrome)

Piazza

Carvalho

Peixoto

et al. 2015

JBRA Assisted Reproduction

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This paper aimed to report a series of 19 cases of uterus didelphys associated with obstructed hemivagina and ipsilateral renal agenesis. This retrospective descriptive observational study included the medical records of 19 patients seen at the Endocrinology Gynecology Sector of the Obstetrics and Gynecology Department of the Federal University of Paraná, and focused on clinical data, complementary exams, patient management, and follow-up. From the 229 patients with genital anomalies seen between 1984 and 2009, 19 (8.3%) were diagnosed with uterus didelphys with vaginal septum and renal agenesis. The patients had a median age of ±16.3 years. Eight subjects (42.6 %) reported abdominal pain; two of them (0.1%) had pelvic masses and seven (36.8%) had dysmenorrhea. Blood retention was confirmed by ultrasound and/ or magnetic resonance imaging of the pelvis, which revealed the existence of a duplicated uterus of the didelphys type with a cystic mass containing old blood obliterating the hemivagina. Urinary tract examination revealed the existence of ipsilateral renal agenesis. Unusual manifestations such as associated infection and rupture of the vaginal septum during sexual intercourse were also reported. The prevalence of uterus didelphys associated with obstructed hemivagina and ipsilateral renal agenesis was 8.3% in a series of 229 genital anomalies. The observance of clinical features is essential for the early identification of the syndrome and the adequate management of the patients.

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Endometriosis from thelarche to midteens: pathogenesis and prognosis, prevention and pedagogy

Cited by 78 publications

References 91 publications

Complete laparoscopic excision of endometriosis in teenagers: is postoperative hormonal suppression necessary?

Complete laparoscopic excision of endometriosis in teenagers: is postoperative hormonal suppression necessary?

Reproductive and Lifestyle Factors Associated with Endometriosis in a Large Cross-Sectional Population Sample

Uterus Didelphys with Obstructed Hemivagina and Ipsilateral Renal Agenesis (OHVIRA Syndrome)

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