Endometriosis in a Man as a Rare Source of Abdominal Pain: A Case Report and Review of the Literature

Rei, Christina; Williams, Thomas; Feloney, Michael

doi:10.1155/2018/2083121

Cited by 45 publications

(59 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As previously noted, Signorile et al [31] found CD10 positive remnants in the deep cul-de-sac only. Finally, Müllerian remnants or coelomic metaplasia in prostate and utricle may explain rare cases of endometriosis reported in males, after long-term high doses of estrogens for prostate carcinoma [36,37]. Immunohistochemical studies in men support both Müllerianosis and metaplasia theories [37].…”

Section: Theories On the Origin Of Endometriosismentioning

confidence: 99%

The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights

Laganà

Garzon

Götte

et al. 2019

IJMS

356

265

View full text Add to dashboard Cite

The etiopathogenesis of endometriosis is a multifactorial process resulting in a heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still far from being fully elucidated, the current review aims to offer a comprehensive summary of the available evidence. We performed a narrative review synthesizing the findings of the English literature retrieved from computerized databases from inception to June 2019, using the Medical Subject Headings (MeSH) unique ID term “Endometriosis” (ID:D004715) with “Etiology” (ID:Q000209), “Immunology” (ID:Q000276), “Genetics” (ID:D005823) and “Epigenesis, Genetic” (ID:D044127). Endometriosis may origin from Müllerian or non-Müllerian stem cells including those from the endometrial basal layer, Müllerian remnants, bone marrow, or the peritoneum. The innate ability of endometrial stem cells to regenerate cyclically seems to play a key role, as well as the dysregulated hormonal pathways. The presence of such cells in the peritoneal cavity and what leads to the development of endometriosis is a complex process with a large number of interconnected factors, potentially both inherited and acquired. Genetic predisposition is complex and related to the combined action of several genes with limited influence. The epigenetic mechanisms control many of the processes involved in the immunologic, immunohistochemical, histological, and biological aberrations that characterize the eutopic and ectopic endometrium in affected patients. However, what triggers such alterations is not clear and may be both genetically and epigenetically inherited, or it may be acquired by the particular combination of several elements such as the persistent peritoneal menstrual reflux as well as exogenous factors. The heterogeneity of endometriosis and the different contexts in which it develops suggest that a single etiopathogenetic model is not sufficient to explain its complex pathobiology.

show abstract

Section: Theories On the Origin Of Endometriosismentioning

confidence: 99%

The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights

Laganà

Garzon

Götte

et al. 2019

IJMS

356

265

View full text Add to dashboard Cite

show abstract

“…While endometriosis and migraine appear to have clear-cut distinctions-anatomically, as well as in terms of clinical diagnosis and disease classification-some shared epidemiological characteristics or similarities suggest a comorbid relationship between them. For instance, similar to endometriosis, which almost exclusively affects women [12], migraine has a substantially higher prevalence in women (15%-18%) compared to men (6%), and women of reproductive age also experience a longer duration of migraine attacks with greater disability [13][14][15][16]. The two disorders share similar risk factors in women including early menarche, menorrhagia, and involvement of the menstrual cycle in their pathogenesis [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity

Adewuyi

Sapkota

Auta

et al. 2020

Genes

View full text Add to dashboard Cite

Observational epidemiological studies indicate that endometriosis and migraine co-occur within individuals more than expected by chance. However, the aetiology and biological mechanisms underlying their comorbidity remain unknown. Here we examined the relationship between endometriosis and migraine using genome-wide association study (GWAS) data. Single nucleotide polymorphism (SNP) effect concordance analysis found a significant concordance of SNP risk effects across endometriosis and migraine GWAS. Linkage disequilibrium score regression analysis found a positive and highly significant genetic correlation (rG = 0.38, P = 2.30 × 10−25) between endometriosis and migraine. A meta-analysis of endometriosis and migraine GWAS data did not reveal novel genome-wide significant SNPs, and Mendelian randomisation analysis found no evidence for a causal relationship between the two traits. However, gene-based analyses identified two novel loci for migraine. Also, we found significant enrichment of genes nominally associated (Pgene < 0.05) with both traits (Pbinomial-test = 9.83 × 10−6). Combining gene-based p-values across endometriosis and migraine, three genes, two (TRIM32 and SLC35G6) of which are at novel loci, were genome-wide significant. Genes having Pgene < 0.1 for both endometriosis and migraine (Pbinomial-test = 1.85 ×10−°3) were significantly enriched for biological pathways, including interleukin-1 receptor binding, focal adhesion-PI3K-Akt-mTOR-signaling, MAPK and TNF-α signalling. Our findings further confirm the comorbidity of endometriosis and migraine and indicate a non-causal relationship between the two traits, with shared genetically-controlled biological mechanisms underlying the co-occurrence of the two disorders.

show abstract

“…Endometriosis is most commonly a disease of women [3]. A total of 16 cases of endometriosis in males has been reported [4]. It occurs mostly in the pelvis [3].…”

Section: Discussionmentioning

confidence: 99%