2023
DOI: 10.1096/fj.202300907
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Endometriosis in the era of precision medicine and impact on sexual and reproductive health across the lifespan and in diverse populations

Linda C. Giudice,
Tomiko T. Oskotsky,
Simileoluwa Falako
et al.

Abstract: Endometriosis is a common estrogen‐dependent disorder wherein uterine lining tissue (endometrium) is found mainly in the pelvis where it causes inflammation, chronic pelvic pain, pain with intercourse and menses, and infertility. Recent evidence also supports a systemic inflammatory component that underlies associated co‐morbidities, e.g., migraines and cardiovascular and autoimmune diseases. Genetics and environment contribute significantly to disease risk, and with the explosion of omics technologies, underl… Show more

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Cited by 19 publications
(26 citation statements)
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“…Despite the systemic approach taken in addressing endometriosis, there is still a notable scarcity of studies employing a multi-omics approach to investigate the disease. 54 It will continue to necessitate further interdisciplinary collaboration and technological innovation to address this gap in current research.…”
Section: Discussionmentioning
confidence: 99%
“…Despite the systemic approach taken in addressing endometriosis, there is still a notable scarcity of studies employing a multi-omics approach to investigate the disease. 54 It will continue to necessitate further interdisciplinary collaboration and technological innovation to address this gap in current research.…”
Section: Discussionmentioning
confidence: 99%
“…Reliance on surgery and marginal advances in medical therapies for symptom relief maintain delayed diagnosis and insufficient care for many 1 . Moreover, menstrual stigma, pain in women, sexism, and racism are impediments globally for life-improving care 3 , 4 . Lack of awareness and/or discomfort regarding menstrual health remains surprisingly prevalent among healthcare providers 3 , 4 .…”
Section: Patient and Public Health Impact Of Underinvestment In Endom...mentioning
confidence: 99%
“…Moreover, menstrual stigma, pain in women, sexism, and racism are impediments globally for life-improving care 3 , 4 . Lack of awareness and/or discomfort regarding menstrual health remains surprisingly prevalent among healthcare providers 3 , 4 .…”
Section: Patient and Public Health Impact Of Underinvestment In Endom...mentioning
confidence: 99%
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