Endometriosis-induced alterations in mouse metaphase II oocyte microtubules and chromosomal alignment: a possible cause of infertility

Mansour, G.; Sharma, Rakesh; Agarwal, Ashok; Falcone, Tommaso

doi:10.1016/j.fertnstert.2009.09.043

Cited by 78 publications

(86 citation statements)

References 46 publications

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“…During the IVF procedure, the mechanical barrier is removed and the fecundity of the spermatozoa can be proven in vitro [23]. In contrast, in women with endometriosis one possible mechanism for reduced fertilization rates is compromised oocyte quality [3,[26][27][28]. This is consistent with results of a study that evaluated pregnancy rates of patients undergoing IVF with donated oocytes, which showed that recipients who had endometriosis conceived with no difference than those with other causes of infertility.…”

Section: Discussionsupporting

confidence: 68%

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Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Komsky-Elbaz

Raziel

Friedler

et al. 2012

J Assist Reprod Genet

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Purpose This study compares the fertilization rate and embryonic development of oocytes randomly inseminated by conventional IVF or ICSI in patients with endometriosis and normozoospermic semen during IVF cycles. Methods Sibling oocytes were randomized to be inseminated either by ICSI or IVF. Rates of fertilization, cleavage, blastulation and embryonic morphology were assessed. Results A total of 786 sibling cumulus-oocyte complexes (COC) were randomized between insemination by conventional IVF (387 COC) or ICSI (399 COC). A significantly higher fertilization rate was found in the ICSI group (ICSI versus IVF, 73.3±23 % versus 54.7±31.9 % respectively; P=0.003), yielding a higher mean number of day 2 embryos (5.2±3.4 versus 3.6±2.9 respectively; P=0.002). Triploid fertilization rate (3PN/COC) was significantly higher in the IVF group compared to the ICSI group (3.9±8.7 % versus 0.9±3.1 % respectively; P=0.02). The morphology score and rate of development of day 2 and 3 embryos were not different between the two groups. Comparison of embryo transfer cycles in which either IVF or ICSI only embryos were transferred did not reveal any statistically significant differences in pregnancy or implantation rates.Conclusion ICSI appears to be a better treatment option than conventional IVF in endometriosis-associated infertility, since it offers the advantages of higher fertilization rate and mean number of embryos and lower rate of total fertilization failure and triploid fertilization.

show abstract

Section: Discussionsupporting

confidence: 68%

“…It is associated with dysmenorrhea, chronic pelvic pain, and infertility. It affects approximately 10 % of the women in their reproductive age and up to 50 % of the women with infertility [1][2][3][4]. The pathophysiology of the infertility in endometriosis is still unknown, although different mechanisms have been suggested [5].…”

Section: Introductionmentioning

confidence: 99%

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Komsky-Elbaz

Raziel

Friedler

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…By exposure of cryopreserved mouse oocytes to the peritoneal fluid from women with endometriosis, Mansour (2010) reported that in the endometriosis group, the cytoskeleton had a higher frequency of abnormal meiotic spindle and chromosomal misalignment, indicating severe damage compared with the control groups. The meiotic spindle plays a critical role in maintaining chromosomal organization and formation of the second polar body.…”

Section: Abnormal Folliculogenesis and Impaired Oocyte Functionmentioning

confidence: 99%

“…Alterations of the spindle may be one of the many causes related to infertility and/or recurrent pregnancy loss in patients with endometriosis (Mansour et al, 2010). Reactive oxygen species (ROS) have been detected in peritoeal fluid of endometriosis patients but are not significantly elevated compared with the control and idiopathic infertility groups (Bedaiwy et al, 2002).…”

Section: Pathomechanism Of Infertility In Endometriosis 347mentioning

confidence: 99%

Pathomechanism of Infertility in Endometriosis

Hendarto¹

2012

Endometriosis - Basic Concepts and Current Research Trends

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“…Endometriosis (EM) is an estrogen-dependent disease characterized by the presence and growth of endometrial tissue outside the uterine cavity (5). EM is strongly associated with infertility, and has severe effects on ovarian and tubal function, while it may also affect endometrial receptivity (6)(7)(8)(9)(10)(11). The development of in vitro fertilization (IVF) is promising for infertile patients with EM; however, the success rate of this procedure remains at a low level (12).…”

Section: Introductionmentioning

confidence: 99%

Advanced oxidation protein products from the follicular microenvironment and their role in infertile women with endometriosis

et al. 2017

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Abstract. Endometriosis (EM) is associated with oxidative stress. Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress, which serve an important role as an inflammatory mediator in various chronic diseases. In order to examine the role of AOPPs in infertile women with EM, the present study analyzed the levels of AOPPs, estradiol (E 2 ) and progesterone (P 4 ) in the follicular fluid (FF) of 89 women with or without EM undergoing in vitro fertilization (IVF). The AOPP concentration in the FF of the EM group was significantly higher when compared with that of the control group (51.5±22.4 vs. 41.8±18.3 µmol/l; P<0.05). However, the FF P 4 levels and blastocyst rate were significantly lower in the EM group compared with the control group (P 4 :1,249.6±465.4 vs. 1,752.7±565.4 ng/ml, P<0.05; blastocyst rate: 0.511±0.322 vs. 0.662±0.278; P<0.05). The AOPP concentration and P 4 level in the FF presented a significant negative correlation in the EM and control groups, as well as in the total cohort of patients (EM group: r=-0.406, P=0.006; control group: r=-0.315, P=0.035; total: r=-0.421, P<0.001). In addition, there was a significant negative correlation between the FF AOPP concentrations and blastocyst rate in the EM group and in the total cohort (EM group: r=-0.376, P=0.012; total: r=-0.367, P<0.001). In conclusion, these results suggested that AOPPs may be a potentially effective marker for predicting the oocyte quality and outcomes of IVF in infertile women with EM.

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Endometriosis-induced alterations in mouse metaphase II oocyte microtubules and chromosomal alignment: a possible cause of infertility

Cited by 78 publications

References 46 publications

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Conventional IVF versus ICSI in sibling oocytes from couples with endometriosis and normozoospermic semen

Pathomechanism of Infertility in Endometriosis

Advanced oxidation protein products from the follicular microenvironment and their role in infertile women with endometriosis

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