Endometriosis, need for a multidisciplinary clinical setting: the internist’s point of view

Abstract

Endometriosis is a common condition characterized by proliferation of endometrial tissue outside the uterus, both in the pelvis and in other extra-pelvic sites. The clinical picture of endometriosis is widely heterogeneous. A correct diagnostic work-up of these patients can sometimes be very difficult, since there are a number of gynecological, intestinal and systemic diseases mimicking endometriosis, as well as other conditions that could be associated with or are a consequence of this disorder. Therefore, multidisciplinary care should be encouraged to ensure correct evaluation and improve the management of these patients.

TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility

“…It is likely that mast cells could play a pivotal role in this association. In fact, besides their known involvement in immediatetype allergic reactions, they also take part in IgE-independent inflammatory and tissue repair processes by releasing inflammatory mediators and cytokines, as in endometriosis [34,35].…”

The possible role of genetic variants in autoimmune-related genes in the development of endometriosis

“…It is likely that mast cells could play a pivotal role in this association. In fact, besides their known involvement in immediate-type allergic reactions, they also take part in IgE-independent inflammatory and tissue repair processes by releasing inflammatory mediators and cytokines, as in endometriosis [26,27].…”

Spontaneous Sigmoid Colon Perforation Based on Endometriosis in Term Pregnancy Case Report

“…bladder, appendix, bowels, umbilicus, mammila, nasal mucosa, lungs, brain etc. Lots of theories have proved multifactorial ethiology with genetic, anatomical, hormonal, immunological, angiogenetic and other, at the time unknown factors [1][2][3][4].…”