Endometriosis-related infertility: assisted reproductive technology has no adverse impact on pain or quality-of-life scores

Santulli, Piétro; Bourdon, Mathilde; Pressé, Marion; Gayet, Vanessa; Marcellin, Louis; Prunet, C.; Ziegler, Dominique de; Chapron, Charles

doi:10.1016/j.fertnstert.2015.12.006

Cited by 65 publications

(48 citation statements)

References 52 publications

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“…Santulli et al. reported detailed data on 102 endometriosis patients where 46% had DIE with bowel involvement. No worsening of symptoms was observed during or after IVF, but no information was given on the principles for conservative treatment.…”

Section: Discussionmentioning

confidence: 99%

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Risk of bowel obstruction during in vitro fertilization treatment of patients with deep infiltrating endometriosis

Seyer‐Hansen

Egekvist

Forman

et al. 2017

Acta Obstet Gynecol Scand

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Introduction. Women with endometriosis often experience pain and infertility. Medical treatment interferes with the possibility of attaining pregnancy. For infertile women with endometriosis, surgery is a possible treatment, but with advanced disease there is an increased risk of serious complications. With only limited pain, women will often be referred for in vitro fertilization treatment instead. The disease is estrogen-dependent and during in vitro fertilization treatment the women could theoretically experience worsening of their symptoms. Material and methods. The study is a retrospective cohort study of 76 women with bowel endometriosis who were treated conservatively and underwent in vitro fertilization treatment. Results. Nine (11.8%) of the women experienced severe worsening of their bowel-related symptoms, including two patients presenting with colon ileus. One additional woman had no previous diagnosis of endometriosis before she presented with subocclusion of the bowel during in vitro fertilization. In all cases the in vitro fertilization treatment was stopped. Conclusions. Our study revealed that bowel endometriosis increases the risk of complications during in vitro fertilization treatment. This is in contrast to several publications. However, our study population is different due to the fact that none of these women had previous operations for bowel endometriosis. In all, 88% of the women completed fertility treatment without need for surgery.

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Section: Discussionmentioning

confidence: 99%

“…In accordance, early reports indicated that IVF in DIE patients can result in bowel or ureter stenosis , although the precise mechanism is unknown. Subsequent prospective studies have not provided evidence of symptomatic progression during IVF treatment , but this discrepancy could reflect less advanced disease in the study populations.…”

Section: Introductionmentioning

confidence: 96%

Risk of bowel obstruction during in vitro fertilization treatment of patients with deep infiltrating endometriosis

Seyer‐Hansen

Egekvist

Forman

et al. 2017

Acta Obstet Gynecol Scand

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“…In Canada and the United States, the incidence of endometriosis ranges from 5–15% in women of reproductive age and 2–5% in postmenopausal women [ 2 3 4 ]. Most women with endometriosis are asymptomatic and only 6–10% of women report pelvic pain [ 5 6 ]. However, this chronic gynecological condition is associated with diverse symptoms including chronic pelvic and lower back pain, dyspareunia, infertility, and dysmenorrhea [ 7 8 ].…”

Section: Introductionmentioning

confidence: 99%

Application of the World Health Organization Quality of Life Instrument, Short Form (WHOQOL-BREF) to patients with endometriosis

et al. 2018

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ObjectiveEndometriosis, a common hormone-dependent chronic inflammatory disease causes various symptoms including pelvic pain, which affect the physical and psychological quality of life in women of reproductive age. The present study aimed to assess the quality of life of Iranian women with endometriosis using the World Health Organization Quality of Life Instrument, Short Form (WHOQOL-BREF) questionnaire.MethodsThis cross-sectional study performed in Tehran between October 2014 and July 2016 included 70 Iranian women with endometriosis. The Iranian version of the WHOQOL-BREF questionnaire was used to measure quality of life in these women. The Pearson's correlation coefficient, the paired and the independent t-tests, and a linear regression model were used to statistically analyze the data using the SPSS software version 16.0.ResultsThe total mean score of the WHOQOL-BREF questionnaire was 80.58. The highest and the lowest mean scores were observed in the environmental (28.15) and the physical health domains (10.59), respectively. A multiple linear regression model (backward method) showed that insurance coverage was associated with the total WHOQOL-BREF score, whereas age, insurance coverage, and income level were associated with domains 1 through 4, respectively (P<0.05).ConclusionEndometriosis affects various aspects of the quality of life of Iranian women who therefore require holistic management focused on both, the physical and psychological aspects of treatment.

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“…To clarify this issue, Santulli et al () evaluated 264 matched pairs of endometriosis patients and disease‐free women undergoing in vitro fertilization. The authors concluded that ART does not aggravate the symptoms of endometriosis or negatively impact the quality of life in endometriosis‐related infertility patients.…”

Section: Introductionmentioning

confidence: 99%

“…To clarify this issue, Santulli et al (2016) In light of this, what would be the rationale for subjecting patients with endometriosis-related infertility to laparoscopy to confirm the diagnosis of endometriosis, as ART may be performed, and pregnancy may be achieved? Nonsurgical methods for the diagnosis of endometriosis could potentially improve the quality of life of these patients (Surrey et al, 2017).…”

mentioning

confidence: 99%

Metabolomic profile as a noninvasive adjunct tool for the diagnosis of Grades III and IV endometriosis‐related infertility

Braga

Montani

Setti

et al. 2019

Molecular Reproduction Devel

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The aim of the present case‐control study was to develop a noninvasive adjuvant tool for the diagnosis of endometriosis. Serum samples from 100 patients undergoing intracytoplasmic sperm injection were split into two groups according to the cause of infertility: an endometriosis group (n = 50), consisting of samples derived from patients with Grade III and IV endometriosis, and a control group (n = 50), comprising samples derived from patients with isolated male factor infertility. The metabolomic profile of each sample was obtained, through mass spectrometry. Partial least squares discriminant analysis was able to clearly classify the endometriosis and control groups. Ten potential biomarkers were selected based on their importance for model prediction. These ions were used to build the receiver‐operating characteristic curve, which presented an area under the curve of 0.904 (95% confidence interval: 0.796–0.985). To validate the model, 30 other samples from infertile women without any evidence of endometriosis were tested. Considering these ions as possible biomarkers, the model was able to correctly classify 84% of the patients. Finally, a similar prediction potential was observed in the model validated set, when samples from the disease‐free group were tested. Serum metabolomics may be useful as a noninvasive adjunct tool for the selection of patients who must undergo laparoscopy for definitive endometriosis diagnosis.

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Endometriosis-related infertility: assisted reproductive technology has no adverse impact on pain or quality-of-life scores

Abstract: Assisted reproduction technology did not exacerbate the symptoms of endometriosis or negatively impact QoL in women with endometriosis as compared with disease-free women.

Cited by 65 publications

References 52 publications

Risk of bowel obstruction during in vitro fertilization treatment of patients with deep infiltrating endometriosis

Risk of bowel obstruction during in vitro fertilization treatment of patients with deep infiltrating endometriosis

Application of the World Health Organization Quality of Life Instrument, Short Form (WHOQOL-BREF) to patients with endometriosis

Metabolomic profile as a noninvasive adjunct tool for the diagnosis of Grades III and IV endometriosis‐related infertility

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