2023
DOI: 10.1111/jog.15851
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Endometriotic mesenchymal stem cells promote the fibrosis process of endometriosis through paracrine TGF‐β1 mediated RASAL1 inhibition

Ying Feng,
Han Dong,
Buzhen Tan

Abstract: BackgroundEndometrial‐derived stem cells are key players in endometriosis (EMs) pathogenesis, while the mechanism involved is still unclear. Herein, the role and regulatory mechanism of endometriotic mesenchymal stem cells (ecto‐MSCs) in regulating fibrosis during EMs progression were investigated.MethodsThe mRNA and protein expressions were assessed using qRT‐PCR, western blot, and immunofluorescence. Flow cytometry was adopted to analyze the markers of MSCs. Transwell assay was adopted to examine endometriot… Show more

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