Despite these differences, it can be challenging to distinguish RHD from left-sided EMF in a clinical context, in particular when faced with mitral regurgitation in a low-resource setting. Making this distinction correctly is of high value, as the medical management, surgical and interventional options, and prognosis are considerably different.
Acute EMF vs. acute RHDAcute mitral regurgitation can be viewed as part of the acute phase of both RHD (acute rheumatic fever, ARF) and EMF. As both are clinical diagnoses, lacking a confirmatory test, additional diagnostic work-up is needed. Of the 2, the clinical presentation of acute rheumatic fever is most clearly defined, and outlined in the Jones Criteria.(3) Indeed, in almost all cases, the diagnosis of ARF requires evidence of a recent streptococcal infection, as the link between untreated or undertreated group A streptococcus (GAS) and ARF is well established. Importantly, the