Endonasal endoscopic surgery for sinonasal squamous cell carcinoma from an oncological perspective

Homma, Akihiro; Nakamaru, Yuji; Lund, Valerie J.; Hanna, Ehab Y.; Kowalski, Luiz Paulo; Toledo, Ronaldo Nunes; Mäkitie, Antti; Rodrigo, Juan P.; Rinaldo, Alessandra; Snyderman, Carl H.; Ferlito, Alfio

doi:10.1016/j.anl.2020.11.018

Cited by 17 publications

(20 citation statements)

References 44 publications

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“…The belief that complications rate was higher for open surgery was instead recently tempered by a meta-analysis [ 85 ]. However, endoscopic surgery is generally considered as a less invasive and disfiguring approach, and is usually preferred whenever the completeness of resection is not undermined [ 83 , 86 , 87 , 88 , 89 ]. Indications to purely endoscopic, endoscopic-assisted, and non-endoscopic procedures for sinonasal cancers according to authors’ experience are summarized in Table 2 .…”

Section: Treatmentmentioning

confidence: 99%

Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

Ferrari

Taboni

Carobbio

et al. 2021

Cancers

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Sinonasal squamous cell carcinoma is a rare tumor affecting the nasal cavity and paranasal sinuses. Several aspects of this disease, ranging from epidemiology to biology, pathology, diagnosis, staging, treatment, and post-treatment surveillance are controversial, and consensus on how to manage this sinonasal cancer is lacking. A narrative literature review was performed to summarize the current evidence and provide the reader with available data supporting the decision-making process in patients affected by sinonasal squamous cell carcinoma, alongside the authors’ personal opinion on the unsolved issues of this tumor. The review has highlighted several advances in molecular definition of epithelial cancers of the sinonasal tract. Surgery represents the pivot of treatment and is performed through an endoscopic transnasal approach whenever feasible. Open surgery is required for a large proportion of cases. Reconstruction of the defect follows principles of skull base and cranio-maxillo-facial reconstruction. Chemotherapy is given as neoadjuvant treatment or concomitantly to radiotherapy. Photon-based radiation therapy has a crucial role in the adjuvant setting. Particle therapy is providing promising results. Management of the neck should be planned based on the presence of clinically appreciable metastases, primary tumor extension, and need for recipient vessels. Biotherapy and immunotherapy are still underexplored therapeutical modalities.

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Section: Treatmentmentioning

confidence: 99%

Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

Ferrari

Taboni

Carobbio

et al. 2021

Cancers

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“…[ 1 ] The most common histologies are squamous cell carcinoma followed by adenocarcinoma and adenoid cystic carcinoma etc. [ 15 16 17 18 19 20 21 ] Early staged tumours can be managed endoscopically[ 22 23 ] whereas open surgical approaches such as craniofacial resection, maxillectomy, midface degloving, lateral rhinotomy, and orbital exenteration deemed necessary for advanced tumours. It is quite challenging to perform surgery with clear margins due to complex anatomy of the region,[ 24 25 26 27 ] and hence, adjuvant radiotherapy becomes a very useful treatment modality in such cases.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of management of sinonasal malignancies at a dedicated cancer institution: A retrospective study

Dhanani

Faisal

Shahid

et al. 2021

Ann Maxillofac Surg

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Introduction: Sinonasal malignancies (SNMs) are a rare and heterogeneous group of cancers with an incidence of 3%–5% of all head-and-neck tumours. The aim of the present study was to identify the characteristic features of SNMs and to analyze the treatment outcomes and the prognostic factors affecting it. Materials and Methods: A retrospective review of patients with SNM treated at a dedicated cancer center of Pakistan between 2004 and 2018 was carried out. All patients with histologically proven diagnosis of malignancy arising from nasal cavity or paranasal sinuses and being treated with curative intent were included. The medical records of 184 cases were utilized for final analysis. Chi-square test was applied to identify significant differences. Five-year disease-specific survival (DSS) was calculated using Kaplan–Meier curve via log-rank test and comparison was made between squamous and nonsquamous histologies. P ≤0.05 was considered statistically significant. Results: Squamous cell carcinoma was the most common histopathology ( n = 62, 33.7%). 130 (70.7%) patients presented with stage IV disease. Nodal metastasis was seen in 24 (13%) patients. Treatment failure was seen in 96 (52.2%) patients and was significantly associated with tumour size and the overall stage. DSS of patients with squamous cell carcinoma was 29% as compared to 52% for patients with nonsquamous histologies ( P = 0.001). Discussion: SNM is a diverse group of cancers presenting in late stages. A higher rate of treatment failure associated significantly with stage of the disease was identified in our study.

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“…Apart from brain and orbit invasion, and even if there are very few survival studies specifically on the prognostic importance of these tumor extensions, most authors currently agree to contraindicate exclusive endoscopic management in cases of invasion of the maxillary infrastructure, the anterior wall of the maxillary sinus, orbital floor, the ascending branch of the maxilla, the nasal bones, the anterior or posterior table of the frontal sinus, the soft palate, massive invasion of the pterygopalatine fossa, the infratemporal fossa, invasion of the cranial nerves beyond their foramen in the skull base, invasion of the cavernous sinus or invasion of the soft tissues of the face [39,82]. However, advances in endoscopic techniques allow us today to reconsider these contraindications in certain selected situations and in experienced teams [61,67,69,83].…”

Section: Other Tumor Invasionsmentioning

confidence: 99%

“…During the 2010-2015 period in a study performed using the American NCDB database, 28% of sinonasal tumors were managed by an exclusive endoscopic approach [84]: this rate is likely to continue to increase in the future as endoscopic techniques and skills are improving. Previously described contraindications to endoscopic surgery, such as invasion of the orbit or brain parenchyma [39,82], are now being challenged with the development of technologies and techniques, and other contraindications should continue to be challenged [61,67,69,83].…”

Section: Future Directions In the Surgical Management Of Sinonasal Cancersmentioning

confidence: 99%

Surgical Management of Sinonasal Cancers: A Comprehensive Review

Chatelet

Simon

Bedarida

et al. 2021

Cancers

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Surgery plays an important role in the treatment of sinonasal cancer. Many surgical approaches have been described, including open, endoscopic, or combined approaches. The choice is based on several criteria: general criteria related to the oncological results and morbidity of each technique, specific criteria related to the tumor (tumor extensions, tumor pathology), the patient, or the surgeon himself. The aims of this review are (i) to provide a complete overview of the surgical techniques available for the management of sinonasal malignant tumors, with a special focus on recent developments in the field of transnasal endoscopic surgery; (ii) to summarize the criteria that lead to the choice of one technique over another. In particular, the oncological outcomes, the morbidity of the different techniques, and the specificities of each histologic subtype will be discussed based on a comprehensive literature review.

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Endonasal endoscopic surgery for sinonasal squamous cell carcinoma from an oncological perspective

Abstract: ✩ This article was written by members and invitees of the International Head and Neck Scientific Group (www.IHNSG.com).

Cited by 17 publications

References 44 publications

Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

Outcomes of management of sinonasal malignancies at a dedicated cancer institution: A retrospective study

Surgical Management of Sinonasal Cancers: A Comprehensive Review

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