Endonasal endoscopic surgery for temporal lobe epilepsy associated with sphenoidal encephalocele

Nobutaka, Mukae; Kuga, Daisuke; Murakami, Daisuke; Komune, Noritaka; Miyamoto, Yusuke; Shimogawa, Takafumi; Sakata, Ayumi; Sekiya, Hiroshi; Iwaki, Toru; Morioka, Takato; Mizoguchi, Masahiro

doi:10.25259/sni_542_2021

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…ECs discovered during seizure investigations are mostly reported among the adult population [5,6,[13][14][15][16][17][18][19][20]. However, there are notable cases in pediatric patients with a history of ECs and the occurrence of seizures [2,[21][22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

The Predictors of Seizures in Patients with Encephalocele: An 11-Year Experience from a Tertiary Hospital

Nejat,

Berchi Kankam,

Heidari

et al. 2023

Pediatr Neurosurg

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Introduction: To investigate and identify the predictors associated with the incidence of seizures in patients with encephalocele (EC). Method: A retrospective analysis was undertaken of patients treated for EC at a tertiary medical center in Tehran between 2010 and 2021. Data including age at presentation, gender, location, size and contents of EC, ventriculomegaly, hydrocephalus, associated anomalies, and neurodevelopmental delay (NDD) were evaluated for their prognostic value. In addition, detailed univariate and multivariate statistical analysis was were performed to identify correlation between independent predictors and seizure incidence. Results: One hundred and two cases of EC were identified. Seventy-one ECs (69.6%) were posterior ECs while 31 (30.4%) were anterior. Neural tissue was found in 43 (42.2%) of the ECs. Thirty-three patients (32.4%) had ventriculomegaly, of which 90.9% underwent shunt placement for progressive or symptomatic hydrocephalus. Seizure was found in 26 (25.5%) patients. On a univariate analysis, presence of other anomalies, post-operative infections and NDD were associated with seizure (p< 0.05). When the anomalies were categorized to intracranial and extracranial groups in univariate analysis none was associated with statistically significant increase in seizure (p value of 0.09 and 0.61 respectively). Although according to multivariate analysis only the association between other associated anomalies and seizure was statistically near significant (OR: 2.0, 95% CI; 0.95-4.2, p=0.049). When the anomalies were categorized to intracranial and extracranial groups none was associated with statistically significant increase in seizure (p value of 0.09 and 0.61 respectively). Children with NDD and postoperative infection were respectively 3.04 and 1.3 (95% CI; 0.9-4.2, p=0.46) times more likely at risk to experience seizures compared to other patients without NDD. Conclusion: We found a rate of 25.5% risk of seizure in patients with EC. This study could not find any significant predictor of seizure in patients children with EC. However, pediatric patients with postoperative infections including sepsis and wound infection and NDD require adequate more considerationstreatment to reduce the risk of seizure.

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