Endophthalmitis caused by streptococcus pneumoniae

Miller, John J.; Scott, Ingrid U.; Flynn, Harry W.; Smiddy, William E.; Corey, Richard P.; Miller, Darlene

doi:10.1016/j.ajo.2004.03.008

Cited by 113 publications

(78 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The conjunctival bacteria isolated in each of the patients were prospectively recorded in the laboratory database, which also contains the medical record numbers and demographic data of the patients, and the origin and collecting date of the samples among other data. Bacteria were grouped as in order to obtain a number of samples as big as possible for carrying out statistical comparisons, and paying attention to their above described pathogenic power in PE cases [17][18][19][20][21][22][23][24][25] (S. aureus, Streptococcus species, Enterococci, Bacillus spp, and most Gram-negative rods).…”

Section: Methodsmentioning

confidence: 99%

“…The devastating effect of these bacteria was also shown after the EVS in several studies. 4,[20][21][22][23][24][25] Taking into account the role of the conjunctival flora as the main source of bacterial contamination during the intraocular surgery, 26 what is remarkable is the low prevalence of these pathogenic bacteria on the conjunctiva of patients operated on for cataract in all the published studies. [27][28][29][30] However, very little is known about whether the clinical characteristics of this small number of patients with pathogenic bacteria colonising their conjunctivas are different.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pathogenic conjunctival bacteria associated with systemic co-morbidities of patients undergoing cataract surgery

Cuesta-Rodríguez

et al. 2013

Eye

View full text Add to dashboard Cite

Purpose To identify the risk of patients undergoing cataract surgery of having pathogenic conjunctival bacteria associated with their systemic co-morbidities. Methods Retrospective study of consecutive patients undergoing their first cataract operation from July 2005 to April 2010. Their preoperative conjunctival bacteria were cultured, identified, and classified in bacterial groups. Their co-morbidities were defined from their clinical data and the answers to systematic questions asked in the anaesthetic evaluation. The Microsoft Access databases of the two data sets were merged for carrying out the statistical analysis. Univariate association of each bacterial group with each co-morbidity was studied by using w 2 -test for categorical data and Student's t-test for continuous variables. Also, logistic regression models were used adjusting for age and sex. SPSS statistic programme, version 18 was used for all these analyses. Endophthalmitis cases in this surgical series were searched. Results In the 8333 selected patients, age was associated with increased conjunctival bacteria in all groups except for Streptococcus pneumoniae and Propionibacteriae. However, male sex was associated with these two groups and also with coagulase-negative Staphylococci, Corynebacterium xerosis, Staphylococcus aureus, and Gram-negative rods. After adjusting for age and sex, S. aureus was associated with diabetes, lung diseases, and renal and heart insufficiency; Gram-negative rods with smoking habit; Enterococci with diabetes; Streptococcus pneumoniae with kyphoscoliosis; and other Streptococci with diabetes and handicapped patients. Conclusion The more pathogenic conjunctival bacteria were more likely associated with patients' co-morbidities, such as diabetes, lung diseases, renal and heart insufficiency, kyphoscoliosis, and smoking habit, than the less pathogenic ones.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pathogenic conjunctival bacteria associated with systemic co-morbidities of patients undergoing cataract surgery

Cuesta-Rodríguez

et al. 2013

Eye

View full text Add to dashboard Cite

show abstract

“…Streptococcus pneumoniae is one of the most common organisms, and it is associated with a poor visual outcome (2). We herein report a patient presenting with endogenous endophthalmitis caused by pneumococcal meningitis.…”

Section: Introductionmentioning

confidence: 99%

Endogenous Endophthalmitis Following <i>Streptococcus pneumoniae</i> Meningitis

Sekiguchi

Inaba

2015

Intern. Med.

View full text Add to dashboard Cite

A 67-year-old man was transported to our hospital and diagnosed with pneumococcal meningitis. We immediately administered ceftriaxone and vancomycin according to the guidelines, but did not administer dexamethasone to him because he had been previously administered antibiotics. His left eye became complicated by endogenous endophthalmitis on the next day, which resulted in blindness, although his meningitis rapidly ameliorated. In comparison to other patients who have been reported to recover from complications with endophthalmitis after the combination therapy of antibiotics, corticosteroids and vitreous surgery, we consider that this patient's poor visual outcome may have been caused by severe inflammation or the breakdown of the blood ocular barrier due to the action of S. pneumoniae. Corticosteroids may be able to successfully treat such inflammation or disruption of the blood ocular barrier.

show abstract

“…Other gram-positive organisms and gram-negative agents are less frequently associated with acute endophthalmitis; however, some of the less common gram-negative organisms are associated with the worst visual outcomes. Streptococci are considered the most virulent and have the worst outcomes Miller 2004;Simunovic 2012;Soriano 2006). Patients' conjunctiva and eyelids are the most common sources of infection.…”

Section: How the Intervention Might Workmentioning

confidence: 99%