Endophthalmitis: Gram Positive Ethiological Agents and Susceptibility to Glycopeptides

Abstract

Endophthalmitis is a serious sight-threatening condition, with a postoperative incidence of 0.13 -0.7%. This study aimed to investigate the spectrum of Gram-positive bacteria causing culture-proven endophthalmitis and their susceptibility to teicoplanin and vancomycin. At this purpose, minimum inhibitory concentrations of teicoplanin and vancomycin of Gram-positive bacteria isolated in the period 2001--2007 from vitreous cultures were determined. Staphylococcus epidermidis was the most common organisms identified (31,8 %), followed by Staphylococcus aureus, Peptococcus spp. e Bacillus spp. All bacteria were susceptible to teicoplanin and vancomycin. The two drugs showed a comparable activity against staphylococci and bacilli, while teicoplanin was more potent against streptococci and anaerobes. In conclusion, teicoplanin showed a spectrum of activity similar or even better that of vancomycin against the most common ethiological agents of postoperative endophthalmitis.

Isolates and antibiotic resistance of culture-proven endophthalmitis cases presented to a referral center in Tehran

“…Our results concur with previous studies that show a 100% sensitivity of gram-positive isolates against vancomycin 1359–12. Among the antibiotics with known intravitreal dosage, amikacin and ceftazidime were the most effective antibiotics against gram-negative organisms.…”

Endophthalmitis following intravitreal injections

“…Teicoplanin is a glycopeptide antibiotic structurally related to vancomycin [16]. In vitro, both drugs have shown comparable activity against staphylococci and bacilli, while teicoplanin was more potent against streptococci and anaerobes [17].…”