Endophthalmitis in the western Sydney region: a case-control study

Reducing the risk for endophthalmitis after cataract surgery: Population-based nested case-control study

“…Preoperative antiseptic preparation and subconjunctival antibiotics were the only chemoprophylactic regimes independently associated with a reduction in endophthalmitis. These results and those in other contemporary studies 7,8,19 add to the body of evidence favoring the use of subconjunctival antibiotics as prophylaxis against endophthalmitis. Subconjunctival injection of antibiotics can achieve bactericidal levels in the anterior chamber for up to 12 hours.…”

“…7,8,14,15 It is believed that clear corneal and temporal incisions do not self-seal well and that their increased use may be contributing to the apparent increased incidence of endophthalmitis in the United States. 5 However, we did not find that wound location or approach or the use of sutured wounds significantly altered the risk.…”

“…4,9,11,13,16,17 There is considerable debate about the significance of wound location with modern cataract surgery. 7,8,14,15 Likewise, the optimum methods of chemoprophylaxis remain controversial, 18 with the use of preoperative conjunctival antiseptic 20 Q 2007 ASCRS and ESCRS Published by Elsevier Inc.…”

“…[5][6][7][8][9][10][11][12][13][14][15][16][17] Much attention in the area has focused on operative technique [7][8][9][10][11][12][13][14][15][16][17] and antibiotic prophylaxis. [7][8][9]18,19 Despite initial hopes, larger studies have not found that the transition from largewound extracapsular cataract extraction to small-incision phacoemulsification cataract extraction reduces the incidence of endophthalmitis. 4,9,11,13,16,17 There is considerable debate about the significance of wound location with modern cataract surgery.…”

Early post-phacoemulsification hypotony as a risk factor for intraocular contamination: In vivo model

“…1,2 A widespread adoption of sutureless clear corneal incisions (CCIs) for phacoemulsification has been a noticeable change in the cataract surgical technique during the same period. The competence of sutureless clear corneal incisions has been scrutinized in several experimental models 3-6 after reports of a higher incidence 1,2,7,8 of endophthalmitis with the CCIs. A reduction in intraocular pressure (IOP) has been shown to result in gaping of the clear corneal wounds with intraocular contamination in these experimental models.…”