Endophthalmitis with brain, lung, and liver abscesses associated with an occult colon cancer

Pyogenic Liver Abscess with a Focus on Klebsiella pneumoniae as a Primary Pathogen: An Emerging Disease with Unique Clinical Characteristics

“…The first reports of a significant rise in incidence of KLA originated from Taiwan; however, other Asian (Japan (17,26,27), Singapore (28,29), Korea (30), India (31), Hong Kong (32)), and non-Asian (Spain (33), United States (7, 10, 12, 58), England (34), Trinidad (35), Australia (36)) countries have followed suit. Many of the reports from non-Asian countries may involve patients of Asian descent but whether the patients are Asian or not, they nearly always have poorly controlled diabetes (19,24,26,34).…”

“…In patients with pyogenic liver abscess, K. pneumoniae may be the etiology of embolic complications in 89% of the cases (18). Extrahepatic abscesses have been reported to occur in 7-12% (18,19,41) of KLA cases, and areas that may be involved include the lung (26,28), pleura (35), kidney (41), prostate (28,37), meninges (7,35), epidural space (41), inner ear (26), brain (18,27), bone (18), skin (43), soft tissue (18,31), and spleen (19), although the most commonly reported organ is the eye (37). Disseminated intravascular coagulation (DIC), septic pulmonary emboli, and acute renal failure (ARF) are well-accepted complications of KLA (17,24,26,35,41).…”

Cryptogenic pyogenic liver abscess as the herald of colon cancer

“…Recently, there have been many case reports of pyogenic liver abscess associated with various colonic diseases. The association with asymptomatic diverticulitis, 3,4 inflammatory bowel disease, [5][6][7] tubulovillous adenoma, 8,9 colon cancer, [10][11][12][13][14][15][16][17][18][19] and even colon polypectomy 20 have been reported. It has been believed that mucosal defects present within colonic lesions or a compromised mucosal barrier separating enteric bacteria from the circulation allows a route for bacteria invasion into the portal system, with subsequent hematogenous spread to the liver.…”

Endogenous endophthalmitis associated with liver abscess caused by Klebsiella pneumoniae

“…Similarly, Cahill et al [5] reported a similar case. Different sources of infection include liver abscess [6], occult colon cancer [7], urinary tract infection and prostate abscess [8].…”