2015
DOI: 10.1016/j.biotechadv.2015.07.004
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Endophytes as in vitro production platforms of high value plant secondary metabolites

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Cited by 186 publications
(115 citation statements)
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References 138 publications
(109 reference statements)
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“…Since then, several patents and studies have been published relating secondary metabolites of fungi and endophytic bacteria (Venugopalan & Srivastava 2015).…”
Section: Discussionmentioning
confidence: 99%
“…Since then, several patents and studies have been published relating secondary metabolites of fungi and endophytic bacteria (Venugopalan & Srivastava 2015).…”
Section: Discussionmentioning
confidence: 99%
“…This may be due to several factors, including the fact that reliable laboratory cultivation techniques for natural products isolation are comparably well established for filamentous fungi and endophytes (Posch et al, 2013; Venugopalan and Srivastava, 2015); more genome sequences of Ascomycetes are publically available (Schmidt-Dannert, 2015); and the genetics of Ascomycetes are better understood, enabling the development of genetic manipulation techniques (Brakhage, 2013; Brakhage and Schroeckh, 2011; Scharf and Brakhage, 2013). Ascomycota could therefore serve as a useful platform for the discovery and/or production of further modified bioactive sesquiterpenoids such as those derived from the Δ6-protoilludene scaffold.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, through in vitro cultivation techniques, it is possible to optimize the production of secondary metabolites with ethnopharmacological importance in several species (Bhuvaneshwari et al, 2016;Venugopalan;Srivastava, 2015). In this context, considering that there is little information regarding the in vitro culture of G. americana, this study aimed to optimize the in vitro germination of G. americana seeds by identifying internal and external factors affecting the germination process.…”
Section: Introductionmentioning
confidence: 99%