Endophytic fungi isolated from medicinal plants: future prospects of bioactive natural products from Tabebuia/Handroanthus endophytes

Abstract

Medicinal plants are a rich source of natural products used to treat many diseases; therefore, they are the basis for a new drug discovery. Plants are capable of generating different bioactive secondary metabolites, but a large amount of botanical material is often necessary to obtain small amounts of the target substance. Nowadays, many medicinal plants are becoming rather scarce. For this reason, it is important to point out the interactions between endophytic microorganisms and the host plant, because endophytes are able to produce highly diverse compounds, including those from host plants that have important biological activities. Thence, this review aims at presenting the richness in bioactive compounds of the medicinal plants from Tabebuia and Handroanthus genera, as well as important aspects about endophyte-plant interactions, with emphasis on the production of bioactive compounds by endophytic fungi, which has been isolated from various medicinal plants for such a purpose. Furthermore, bio-prospection of natural products synthesized by endophytes isolated from the aforementioned genera used in traditional medicine could be used to treat illnesses.

Agricultural and Other Biotechnological Applications Resulting from Trophic Plant-Endophyte Interactions

“…The fact that inoculation of plants with endophytes usually results in an effective decrease in fungal, bacterial, and viral diseases, and reduces damage that is caused by insects and nematodes has been broadly studied [80][81][82][83][84][85][86]. Gai et al [83] isolated bacterial communities associated with the heads of surface-sterilized insect vectors of X. fastidiosa subsp.…”

Handroanthus obscurus (Bureau & K. Schum.) Mattos “tahuari”: una puesta al día

“…La flora peruana es una fuente invaluable de plantas medicinales, un gran número de productos vegetales nativos andinos y amazónicos son usados como medicina tradicional en Perú, con el fin de tratar diferentes enfermedades (1) ; muchos de estos efectos ya están siendo comprobados por la ciencia (2)(3)(4)(5)(6) , en estos estudios se incluyen a especies de la familia Bignoniaceae (7) y del género Handroanthus (8,9) .…”

EFEITO CITOTÓXICO E GENOTÓXICO DE Crescentia cujete L. (BIGNOCIACEAE) ATRAVÉS DO BIOTESTE Allium cepa

“…Muitas espécies da família Bignoniaceae têm sido utilizadas na medicina popular no tratamento e cura de doenças. Esta família contém muitos componentes químicos diferentes, tais como os flavonóides, terpenóides, quinonas, mas principalmente nafthoquinonas e compostos aromáticos (WARASHIMA et al, 2006;GÓMEZ;LUIZ, 2018). Sendo que o gênero Crescentia está entre os membros mais importantes devido às suas propriedades medicinais.…”