Endophytic fungi mediates production of bioactive secondary metabolites via modulation of genes involved in key metabolic pathways and their contribution in different biotechnological sector

Toppo, Prabha; Kagatay, Lahasang Lamu; Gurung, Ankita; Singla, Priyanka; Chakraborty, Rakhi; Roy, Swarnendu; Mathur, Piyush

doi:10.1007/s13205-023-03605-z

Cited by 9 publications

(2 citation statements)

References 331 publications

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“…[37]. Although the genus Trichoderma has been widely studied due to the diversity of natural environmental systems, the genus Trichoderma parasitized by different biological groups is likely to produce more natural products with novel structures and significant biological activities under the influence of an environmental host and their own evolution [35,38,39]. Therefore, the genus Trichoderma is a significantly promising strategic bio-resource for the excavation of structurally novel lead natural products, and further extensive research efforts on their chemical constituents are still called upon for their great research value and spacious application prospect.…”

Section: Resultsmentioning

confidence: 99%

Koninginins X-Z, Three New Polyketides from Trichoderma koningiopsis SC-5

Peng,

Tan,

Sang

et al. 2023

Molecules

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Koninginins X-Z (1–3), three novel polyketides, were isolated from the solid fermentation of the endophytic fungus Trichoderma koningiopsis SC-5. Their structures, including the absolute configurations, were comprehensively characterized by a combination of NMR spectroscopic methods, HRESIMS, 13C NMR, DFT GIAO 13C NMR, and electronic circular dichroism calculations as well as single crystal X-ray diffraction. In addition, all the compounds were evaluated for antifungal activity against Candida albicans.

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Section: Resultsmentioning

confidence: 99%

Koninginins X-Z, Three New Polyketides from Trichoderma koningiopsis SC-5

Peng,

Tan,

Sang

et al. 2023

Molecules

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“…Fungi create secondary metabolites, which are characterized as low molecular weight molecules adapted for specialized tasks in nature but not necessary for growth. New, highly effective medications are desperately needed to treat diseases like cancer, bacterial drug resistance, and fungal infections 2 , Numerous active chemicals with a wide range of biological characteristics are produced by endophytic fungus 3 .…”

Section: Introductionmentioning

confidence: 99%

Antifungal Potential of Cladosporium sp. (Endophytic fungi) Associated with Olea europaea L. Leaves

Mezher,

Abed

2023

Baghdad Sci.J

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In the leaves of Olea europaea L. Olive trees an endophytic fungus was discovered. Cladosporium sp. was identified to be the fungus based on its morphological characteristics and nuclear ribosomal DNA ITS sequence analysis and was registered in NCBI as the Cladosporium genus has been registered under the number (0P939922.1) The species was not specified, and it was considered of unknown species after comparing it to global isolates. In comparison to olive leaf extract, Cladosporium sp. including total flavonoid, total phenolic, total terpenoid, and total saponins, Which were 121.9%, 198.1%, 89.13%, and 29.87 % respectively compared to its content in olive leaf extract, which was 61.54 %, 67.88 % , 17.1%, and 20.19% respectively. The Cladosporium sp. extract inhibited the growth of 27 isolates belonging to different species of candida which were Candida albicans , C. lypolitica , C. tropicalis , C. sphaerica , C. krusei , C. guilliermondii , C. parapsilosis , C. norvegicus , C. glabrata , and C. kefyr , the inhibition effects increased with increasing concentration to reach the highest level to suppress fungal growth when concentrated 30 mg/ml. This proves the antifungal potential of endophytic fungi in the future.

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