Endophytic Mycoflora: Antibacterial Secondary Metabolites and Their Therapeutic Potential

Aharwal, Ravindra Prasad; Kumar, Suneel; Sandhu, Sardul Singh

doi:10.1007/s40495-021-00261-w

Cited by 5 publications

(2 citation statements)

References 154 publications

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“…As per the studies by many researchers, the shikimic or enzymatic pathways are also involved in the synthesis of secondary metabolites in endophytic fungi (Aharwal et al 2021). On the other hand, various studies on genome sequencing indicate that the genes responsible for the production of similar secondary metabolites in the host and their respective endophytes not the same (Mattoo and Nonzom ).…”

Section: Genes Responsible For Antimicrobial Productionmentioning

confidence: 95%

An insight into endophytic antimicrobial compounds: an updated analysis

Digra

Nonzom

2023

Plant Biotechnol Rep

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Resistance in micro-organisms against antimicrobial compounds is an emerging phenomenon in the modern era as compared to the traditional world which brings new challenges to discover novel antimicrobial compounds from different available sources, such as, medicinal plants, various micro-organisms, like, bacteria, fungi, algae, actinomycetes, and endophytes. Endophytes reside inside the plants without exerting any harmful impact on the host plant along with providing ample of benefits. In addition, they are capable of producing diverse antimicrobial compounds similar to their host, allowing them to serve as useful micro-organism for a range of therapeutic purposes. In recent years, a large number of studies on the antimicrobial properties of endophytic fungi have been carried out globally. These antimicrobials have been used to treat various bacterial, fungal, and viral infections in humans. In this review, the potential of fungal endophytes to produce diverse antimicrobial compounds along with their various benefits to their host have been focused on. In addition, classification systems of endophytic fungi as well as the need for antimicrobial production with genetic involvement and some of the vital novel antimicrobial compounds of endophytic origin can further be utilized in the pharmaceutical industries for various formulations along with the role of nanoparticles as antimicrobial agents have been highlighted.

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Section: Genes Responsible For Antimicrobial Productionmentioning

confidence: 95%

An insight into endophytic antimicrobial compounds: an updated analysis

Digra

Nonzom

2023

Plant Biotechnol Rep

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“…Endophytes are defined as microorganisms that live asymptomatically in plant tissues, causing no damage to their hosts, and are isolated from surfacesterilized plant explants. The term endophytes means "in the plant" (from the Greek endon = within, phyton = plant), and most endophytes originated in the rhizosphere and phyllosphere 1 . Endophytic fungi are regarded as the unseen inhabitants of the microbial world and represent an underutilized source of novel therapeutics and compounds.…”

Section: Introductionmentioning

confidence: 99%

Antifungal Potential of Cladosporium sp. (Endophytic fungi) Associated with Olea europaea L. Leaves

Mezher,

Abed

2023

Baghdad Sci.J

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In the leaves of Olea europaea L. Olive trees an endophytic fungus was discovered. Cladosporium sp. was identified to be the fungus based on its morphological characteristics and nuclear ribosomal DNA ITS sequence analysis and was registered in NCBI as the Cladosporium genus has been registered under the number (0P939922.1) The species was not specified, and it was considered of unknown species after comparing it to global isolates. In comparison to olive leaf extract, Cladosporium sp. including total flavonoid, total phenolic, total terpenoid, and total saponins, Which were 121.9%, 198.1%, 89.13%, and 29.87 % respectively compared to its content in olive leaf extract, which was 61.54 %, 67.88 % , 17.1%, and 20.19% respectively. The Cladosporium sp. extract inhibited the growth of 27 isolates belonging to different species of candida which were Candida albicans , C. lypolitica , C. tropicalis , C. sphaerica , C. krusei , C. guilliermondii , C. parapsilosis , C. norvegicus , C. glabrata , and C. kefyr , the inhibition effects increased with increasing concentration to reach the highest level to suppress fungal growth when concentrated 30 mg/ml. This proves the antifungal potential of endophytic fungi in the future.

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