2022
DOI: 10.21203/rs.3.rs-1880582/v1
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Endoplasmic reticulum protein 29 inhibits epithelial-mesenchymal-transformation in placental trophoblast cells and promotes the development of intrahepatic cholestasis of pregnancy in pregnant rats

Abstract: Background Intrahepatic cholestasis of pregnancy (ICP) is a common pregnancy specific liver disease, which has little impact on the mother and mainly causes adverse fetal outcomes. Endoplasmic reticulum protein 29 (ERp29) plays a key role in protein folding, transport and secretion, and participates in biological events such as apoptosis, oxidative stress, lipid metabolism, immune regulation and so on. Epithelial mesenchymal transformation (EMT) is the process of epithelial cells losing polarity and adhesion,… Show more

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