Endoplasmic reticulum stress and angiogenesis

Do, Myoung‐Sool; Kubaĭchuk, KI; Ov, Hubenia; Kryvdiuk, IV; Khomenko, IeV; Herasymenko, RM; Sulik, RV; Nk, Murashko; Oh, Myounghak

doi:10.15407/fz59.04.093

Cited by 2 publications

(2 citation statements)

References 76 publications

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“…The ER plays a vital role in cellular physiology by ensuring the correct folding of secretory and transmembrane proteins; this important function is monitored and dynamically controlled by the UPR (Minchenko, Kubaichuk et al 2013). Over the past two decades, new research has provided exciting evidence suggesting that activation of the UPR not only maintains a homeostatic environment in the ER, which in a broader context is crucial for cellular proteostasis, but also is involved in regulation of a wide variety of other cellular processes, including cellular proliferation and differentiation, inflammation, apoptosis, and angiogenesis.…”

Section: Perspectives and Future Directionsmentioning

confidence: 99%

The unfolded protein response in retinal vascular diseases: Implications and therapeutic potential beyond protein folding

Zhang

Jacey

Bhatta

et al. 2015

Progress in Retinal and Eye Research

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Angiogenesis is a complex, step-wise process of new vessel formation that is involved in both normal embryonic development as well as postnatal pathological processes, such as cancer, cardiovascular disease, and diabetes. Aberrant blood vessel growth, also known as neovascularization, in the retina and the choroid is a major cause of vision loss in severe eye diseases, such as diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity, and central and branch retinal vein occlusion. Yet, retinal neovascularization is causally and dynamically associated with vasodegeneration, ischemia, and vascular remodeling in retinal tissues. Understanding the mechanisms of retinal neovascularization is an urgent unmet need for developing new treatments for these devastating diseases. Accumulating evidence suggests a vital role for the unfolded protein response (UPR) in regulation of angiogenesis, in part through coordinating the secretion of pro-angiogenic growth factors, such as VEGF, and modulating endothelial cell survival and activity. Herein, we summarize current research in the context of endoplasmic reticulum (ER) stress and UPR signaling in retinal angiogenesis and vascular remodeling, highlighting potential implications of targeting these stress response pathways in the prevention and treatment of retinal vascular diseases that result in visual deficits and blindness.

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Section: Perspectives and Future Directionsmentioning

confidence: 99%

The unfolded protein response in retinal vascular diseases: Implications and therapeutic potential beyond protein folding

Zhang

Jacey

Bhatta

et al. 2015

Progress in Retinal and Eye Research

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“…In humans there are four PFKFB isozymes (PFKFB-1, -2, -3 and -4), that differ in their tissue distribution and regulatory properties [34,35]. PFKFB-3 and PFKFB-4 isozymes overexpression in gastric, colon, lung and breast malignant tumors contributes to proliferation and survival of cancer cells [36][37][38][39][40]. Furthermore, an up-regulation of PFKFB-3 protein, but not mRNA levels was demonstrated in high-grade astrocytomas [41].…”

Section: Introductionmentioning

confidence: 99%

Single‐walled carbon nanotubes affect the expression of the CCND2 gene in human U87 glioma cells

Minchenko

Tsymbal

Minchenko

et al. 2016

Materialwissenschaft Werkst

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The effect of single-walled carbon nanotubes (SWCNTs) on the expression level of several genes, related to cell cycle control, cell proliferation and migration in human glioma cell line U87 was investigated. The exposure of human U87 glioma cells to single-walled carbon nanotubes in different concentrations during 24 of 48 h affects the expression of CCND2 (Cyclin D2), DTNA (Dystrobrevin alpha), PARVB (parvin beta), DUSP1 (dual specificity phosphatase 1), PFKFB3 (6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase-3) and PFKFB4 genes at mRNA level, as well as the expression of alternative splice variants of DTNA, PFKFB3 and PFKFB4 transcripts. In case of CCND2 gene a strong, time and dose-dependent suppressive effect was observed. The effect of single-walled carbon nanotubes on the expression level of PFKFB3, PFKFB4, and PARVB was also suppressive but less prominent. At the same time, the expression of DUSP1 and DTNA genes is up-regulated in cells treated by single-walled carbon nanotubes. Thus, single-walled carbon nanotubes exert anti-proliferative properties in U87 glioma cells, as they down-regulate the expression of proliferation-related genes (CCND2, PARVB, PFKFB3, and PFKFB4) and up-regulate DUSP1 and DTNA genes, which control apoptosis.

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Endoplasmic reticulum stress and angiogenesis

Cited by 2 publications

References 76 publications

The unfolded protein response in retinal vascular diseases: Implications and therapeutic potential beyond protein folding

The unfolded protein response in retinal vascular diseases: Implications and therapeutic potential beyond protein folding

Single‐walled carbon nanotubes affect the expression of the CCND2 gene in human U87 glioma cells

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