Endoplasmic Reticulum Stress and Emerging Therapeutic Targets in Cancer

Yeap, Jia Wen; Tan, Mei Lan

doi:10.1007/978-3-030-80962-1_271-1

Cited by 1 publication

(1 citation statement)

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“…To circumvent this situation, adaptive UPRs are unleashed by the cells through three distinct signalling pathways; namely Inositol‐requiring enzymes 1α (IRE1α), Protein kinase RNA‐like ER kinase (PERK) and Activating transcription factor 6 (ATF6) (Figure 2). [28–30] Lately, these UPR signalling pathways have been implicated in different pathological states including cancer [31–34] . IRE1α has an N‐terminal domain in the ER and a C‐terminal domain in the cytosol, which can act both like a kinase and RNase.…”

Section: Er Signalling In Cancermentioning

confidence: 99%

Biomaterials for Targeting Endoplasmic Reticulum in Cancer

Mishra,

Sengupta,

Basu

2024

Chemistry An Asian Journal

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Endoplasmic reticulum (ER) is one of the most important sub‐cellular organelles which controls myriads of biological functions including protein biosynthesis with proper functional folded form, protein misfolding, protein transport into Golgi body for secretion, Ca2+ homeostasis and so on. Subsequently, dysregulation in ER function leads to ER stress followed by disease pathology like cancer. Hence, targeting ER in the cancer cells emerged as one of the futuristic strategies for cancer treatment. However, the major challenge is to selectively and specifically target ER in the sub‐cellular milieu in the cancer tissues, due to the lack of ER targeting chemical moieties to recognize the ER markers. To address this, in last decade, numerous biomaterials were explored to selectively impair and image ER in cancer cells to induce ER stress. This review outlines those biomaterials which consists of carbon and silicon materials, lipid nanoparticles (liposomes and micelles), supramolecular self‐assembled nanostructures, cell membrane coated nanoparticles and metallic nanoparticles. Moreover, we also discussed the challenges and possible solutions of this promising field to usher the readers towards next‐generation ER targeted cancer therapy.

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Section: Er Signalling In Cancermentioning

confidence: 99%