Endoplasmic reticulum stress as a target for retinoids in cancer treatment

Walczak-Szeffer, Anna; Piastowska-Ciesielska, Agnieszka Wanda

doi:10.1016/j.lfs.2024.122892

Life Sciences

2024

DOI: 10.1016/j.lfs.2024.122892

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Endoplasmic reticulum stress as a target for retinoids in cancer treatment

Anna Walczak-Szeffer,

Agnieszka Wanda Piastowska-Ciesielska

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Endoplasmic Reticulum Stress in Bronchopulmonary Dysplasia: Contributor or Consequence?

Wu,

Teng,

Jing

et al. 2024

Cells

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Bronchopulmonary dysplasia (BPD) is the most common complication of prematurity. Oxidative stress (OS) and inflammation are the major contributors to BPD. Despite aggressive treatments, BPD prevalence remains unchanged, which underscores the urgent need to explore more potential therapies. The endoplasmic reticulum (ER) plays crucial roles in surfactant and protein synthesis, assisting mitochondrial function, and maintaining metabolic homeostasis. Under OS, disturbed metabolism and protein folding transform the ER structure to refold proteins and help degrade non-essential proteins to resume cell homeostasis. When OS becomes excessive, the endogenous chaperone will leave the three ER stress sensors to allow subsequent changes, including cell death and senescence, impairing the growth potential of organs. The contributing role of ER stress in BPD is confirmed by reproducing the BPD phenotype in rat pups by ER stress inducers. Although chemical chaperones attenuate BPD, ER stress is still associated with cellular senescence. N-acetyl-lysyltyrosylcysteine amide (KYC) is a myeloperoxidase inhibitor that attenuates ER stress and senescence as a systems pharmacology agent. In this review, we describe the role of ER stress in BPD and discuss the therapeutic potentials of chemical chaperones and KYC, highlighting their promising role in future therapeutic interventions.

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Endoplasmic Reticulum Stress in Bronchopulmonary Dysplasia: Contributor or Consequence?

Wu,

Teng,

Jing

et al. 2024

Cells

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Endoplasmic reticulum stress as a target for retinoids in cancer treatment

Cited by 1 publication

References 160 publications

Endoplasmic Reticulum Stress in Bronchopulmonary Dysplasia: Contributor or Consequence?

Endoplasmic Reticulum Stress in Bronchopulmonary Dysplasia: Contributor or Consequence?

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