2020
DOI: 10.1530/rep-19-0492
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Endoplasmic reticulum stress attenuation promotes bovine oocyte maturation in vitro

Abstract: We have previously reported that regulation of endoplasmic reticulum (ER) stress during in vitro culture acutely increases bovine embryo developmental rate and cryotolerance; these data indicate that ER stress is a critical factor reducing the quality of in vitro-produced embryos. In the current follow-up study, we examined whether ER stress attenuation during in vitro maturation influences meiotic maturation, oocyte quality, and subsequent embryonic development. Bovine cumulus oocyte complexes (COCs) derived … Show more

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Cited by 26 publications
(12 citation statements)
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“…The swelling of ER in cerebellar neurons can be observed when exposed to ACR on rats, accompanied by the increased expression of stress-related proteins in the endoplasmic reticulum for the muscle strength and motor coordination ability of rats (Yw et al, 2021). The addition of tauroursodeoxycholic acid to bovine cumulus-oocyte complex can inhibit the expression level endoplasmic reticulum stress-related proteins and apoptosis-related genes in bovine oocytes, thus improving the quality of oocytes and the development rate of blastocysts (Khatun et al, 2020). Therefore, ACR could affect protein The Golgi apparatus is a polar organelle composed of flattened membrane sacs, small vesicles, and large vesicles, which help the immature proteins transferred from the ER to modify and fold to form functional proteins (Stalder and Gershlick, 2020).…”
Section: Discussionmentioning
confidence: 99%
“…The swelling of ER in cerebellar neurons can be observed when exposed to ACR on rats, accompanied by the increased expression of stress-related proteins in the endoplasmic reticulum for the muscle strength and motor coordination ability of rats (Yw et al, 2021). The addition of tauroursodeoxycholic acid to bovine cumulus-oocyte complex can inhibit the expression level endoplasmic reticulum stress-related proteins and apoptosis-related genes in bovine oocytes, thus improving the quality of oocytes and the development rate of blastocysts (Khatun et al, 2020). Therefore, ACR could affect protein The Golgi apparatus is a polar organelle composed of flattened membrane sacs, small vesicles, and large vesicles, which help the immature proteins transferred from the ER to modify and fold to form functional proteins (Stalder and Gershlick, 2020).…”
Section: Discussionmentioning
confidence: 99%
“…Curcumin has been reported to increase the expression of ATF4 and CHOP, which are considered the hallmarks of ER stress-induced apoptosis (49,50). During severe or prolonged ER stress, ATF4 is activated and binds to AARE1 on the CHOP promoter, further promoting the expression of the ER stress-associated apoptotic factor CHOP (51)(52)(53). After curcumin treatment, the expression levels of ATF4, and CHOP increased in ACC cells in vitro and in vivo.…”
Section: Discussionmentioning
confidence: 99%
“…The inhibition of either of CK1 and CHK2 as well as upstream kinase ataxia telangiectasia mutated (ATM) saves oocytes in mouse ovaries from apoptosis [ 83 ]. Here, tauroursodeoxycholic acid (TUDCA), a selective inhibitor of ER stress that has been approved by the Food and Drug Administration for clinical use, inhibits granulosa cell apoptosis and promotes oocyte maturation [ 84 , 85 ]. TUDCA also limits apoptosis by decreasing palmitate-induced JNK phosphorylation, PUMA upregulation and BAX activation [ 86 ].…”
Section: Puma Induces Apoptosis In the Oocytesmentioning
confidence: 99%