Endoplasmic reticulum stress impairs the immune regulation property of macrophages in asthmatic patients

Mo, Lihua; Liu, Yu; Xu, Xuejie; Wang, Xinxin; Zhang, Shuang; Hu, Suqin; Wu, Yongjin; Tang, Zhiyuan; Huang, Qinmiao; Li, Jing; Sun, Xizhuo; Yang, Pingchang

doi:10.1016/j.clim.2023.109639

Cited by 10 publications

(3 citation statements)

References 39 publications

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“…Published data indicate that Rnf20 plays a role in affecting the function of regulatory T cells by causing the degradation of Foxp3 [25]. Our previous work demonstrated that exposure to environmental pollutant, 3-methyl-4-nitophenol, exacerbated ER stress and induced PD-L1 and IL-10 degradation in macrophages, in which Rnf20 played a crucial role [16]. The RNAseq results (Figure 1a) show that exposure of mice to restraint stress and specific antigens induces the expression of Rnf20 in Tr1 cells.…”

Section: Xbp1 Mediates the Effects Of Corticosterone On Inducing Rnf2...mentioning

confidence: 97%

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Psychological stress to ovalbumin peptide‐specific T‐cell receptor transgenic mice impairs the suppressive ability of type 1 regulatory T cell

Liu,

Xu,

Liao

et al. 2024

Immunology

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Numerous diseases of the immune system can be traced back to the malfunctioning of the regulatory T cells. The aetiology is unclear. Psychological stress can cause disruption to the immune regulation. The synergistic effects of psychological stress and immune response on immune regulation have yet to be fully understood. The intention of this study is to analyse the interaction between psychological stress and immune responses and how it affects the functional status of type 1 regulatory T (Tr1) cells. In this study, ovalbumin peptide T‐cell receptor transgenic mice were utilised. Mice were subjected to restraint stress to induce psychological stress. An airway allergy murine model was established, in which a mouse strain with RING finger protein 20 (Rnf20)‐deficient CD4+ T cells were used. The results showed that concomitant exposure to restraint stress and immune response could exacerbate endoplasmic reticulum stress in Tr1 cells. Corticosterone was responsible for the elevated expression of X‐box protein‐1 (XBP1) in mouse Tr1 cells after exposure to both restraint stress and immune response. XBP1 mediated the effects of corticosterone on inducing Rnf20 in Tr1 cells. The reduction of the interleukin‐10 expression in Tr1 cells was facilitated by Rnf20. Inhibition of Rnf20 alleviated experimental airway allergy by restoring the immune regulatory ability of Tr1 cells. In conclusion, the functions of Tr1 cells are negatively impacted by simultaneous exposure to psychological stress and immune response. Tr1 cells' immune suppressive functions can be restored by inhibiting Rnf20, which has the translational potential for the treatment of diseases of the immune system.

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Section: Xbp1 Mediates the Effects Of Corticosterone On Inducing Rnf2...mentioning

confidence: 97%

“…An example is that XBP1 disturbs the homeostasis of dendritic cells to compromise the anti-tumour ability [13]. Previous studies have shown that ER stress can upregulate the expression of RING finger protein 20 (Rnf20) [14][15][16]. Rnf20, a ubiquitin E3 ligase, can cause targeting proteins to ubiquitinate and undergo degradation [17].…”

Section: Introductionmentioning

confidence: 99%

Psychological stress to ovalbumin peptide‐specific T‐cell receptor transgenic mice impairs the suppressive ability of type 1 regulatory T cell

Liu,

Xu,

Liao

et al. 2024

Immunology

Self Cite

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“…26 Recently, cumulative investigates have disclosed that ERS can promote the progression of many diseases, including depression, 27 cardiovascular, 28,29 neurodegenerative diseases, 30 cancer, 31 obesity, and diabetes. [32][33][34][35] These years, numerous investigations have reported that ERS is closely associated with the development of lung diseases such as silicosis, 36 asthma, 37 non-small cell lung cancer, 38 acute lung injury, 39 and IPF. 40,41 It has been demonstrated that during the progress of IPF, ERS is activated and administration of the ERS inhibitors can alleviate fibroblast proliferation and improve lung function, suggesting an important factor of ERS for the pathogenesis of IPF.…”

Section: Introductionmentioning

confidence: 99%

Effects of Natural Products through Inhibiting Endoplasmic Reticulum Stress on Attenuation of Idiopathic Pulmonary Fibrosis

Deng,

Liu,

Chen

et al. 2024

DDDT

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With ever-increasing intensive studies of idiopathic pulmonary fibrosis (IPF), significant progresses have been made. Endoplasmic reticulum stress (ERS)/unfolded protein reaction (UPR) is associated with the development and progression of IPF, and targeting ERS/UPR may be beneficial in the treatment of IPF. Natural product is a tremendous source of new drug discovery, and accumulating studies have reported that many natural products show potential therapeutic effects for IPF via modulating one or more branches of the ERS signaling pathway. Therefore, this review focuses on critical roles of ERS in IPF development, and summarizes herbal preparations and bioactive compounds which protect against IPF through regulating ERS.

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Probiotic nucleotides increase IL-10 expression in airway macrophages to mitigate airway allergy

Xue,

Liu,

Xie

et al. 2024

Inflamm. Res.

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Endoplasmic reticulum stress impairs the immune regulation property of macrophages in asthmatic patients

Cited by 10 publications

References 39 publications

Psychological stress to ovalbumin peptide‐specific T‐cell receptor transgenic mice impairs the suppressive ability of type 1 regulatory T cell

Psychological stress to ovalbumin peptide‐specific T‐cell receptor transgenic mice impairs the suppressive ability of type 1 regulatory T cell

Effects of Natural Products through Inhibiting Endoplasmic Reticulum Stress on Attenuation of Idiopathic Pulmonary Fibrosis

Probiotic nucleotides increase IL-10 expression in airway macrophages to mitigate airway allergy

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