Endoscopic and biopsy findings of the upper digestive tract in patients with amyloidosis

Tada, Shuji; lida, Mitsuo; Iwashita, Akinori; Matsui, Toshiyuki; Fuchigami, Takeshi; Yamamoto, Tetsuya; Yao, Tsuneyoshi; Fujishima, Masatoshi

doi:10.1016/s0016-5107(90)70913-3

Cited by 160 publications

(116 citation statements)

References 15 publications

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“…significantly correlated with the frequency of endoscopic findings of fine granular appearance and polypoid protrusions [6]. In secondary amyloidosis (serum acute phase-reactant, amyloid A protein), endoscopic findings have been related to deposition occurring mainly in the propria mucosae with symptoms of diarrhea, as in our patient [3].…”

Section: Discussionsupporting

confidence: 73%

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Amyloidosis of the colon

Dawkins¹,

Hanchard²,

Lee³

2017

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.IJCRI publishes Review Articles, Case Series, Case Reports, Case in Images, Clinical Images and Letters to Editor. Website: www.ijcasereportsandimages.com Amyloidosis of the ColonYvonne M. Dawkins, Barrie Hanchard, Michael G. Lee ABSTRACT Introduction: Gastrointestinal amyloidosis is rare in western countries. The most frequent clinical manifestation in all patients with amyloidosis is weight loss and gastrointestinal bleeding. However, diarrhea is seen in patients with secondary amyloidosis. Case Report: A 76-year-old male presented with a six-month history of diarrhea, and had three episodes of bloody diarrhea over a two-day period prior to admission. There was associated anorexia and weight loss. Colonoscopy revealed pancolitis and a presumptive diagnosis of ulcerative colitis was made. He had resolution of his diarrhea after four days on prednisone. However, biopsy revealed colonic amyloid deposition. He also had non-nephrotic range proteinuria and cardiomyopathy and likely had systemic amyloidosis, affecting the heart and kidney in addition to colonic involvement. Conclusion:The intestinal presentation may be similar to several conditions as a result of the protean manifestations of gastrointestinal amyloidosis. A high index of suspicion should be maintained in any patient presenting with chronic diarrhea and edema to avoid delay in diagnosis and treatment.

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Section: Discussionsupporting

confidence: 73%

“…The endoscopic appearance of gastrointestinal amyloidosis is non-specific and may include a fine granular appearance of the mucosa, erosions, ulcerations, mucosal friability and polypoid protrusions [6]. These findings may reflect amyloid deposition in the mucosa or submucosa.…”

Section: Discussionmentioning

confidence: 99%

Amyloidosis of the colon

Dawkins¹,

Hanchard²,

Lee³

2017

IJCRI

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“…Amyloidosis can appear as submucosal tumors, polyps, antral narrowing, thickened irregular gastric folds or loss of rugal folds. In a case series of 37 cases of GI amyloidosis, the relative frequency of amyloid deposition was 100% in the duodenum, 95% in the stomach, and 91% in the colorectum [5].…”

Section: Discussionmentioning

confidence: 98%

Light-chain amyloidosis (AL amyloidosis) presenting as gastrointestinal bleeding

Liyanaarachchi

Kalubowila

Ratnayake

et al. 2017

J. Postgrad. Inst. Med.

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“…Endoscopic biopsy is considered to be a useful method to diagnose amyloidosis (1), however endoscopic findings are diverse and nonspecific (2). "Nodular gastritis" has been considered to be related to HP infection (3), but in the present case HP infection was negative.…”

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confidence: 79%

Secondary Amyloidosis Presenting as a Unique form of Nodular Gastritis

Asayama

Nagata

2012

Intern. Med.

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A 49-year-old woman complained of epigastric pain of 1 month duration. She was diagnosed with rheumatoid arthritis 14 years previously, but her compliance for taking medicine was poor. Upper endoscopy showed multiple nodular elevations in the gastric body (Picture 1) which were more clearly revealed with indigo-carmine dye (Picture 2). Biopsy specimens showed non-structural deposits in the vessel wall and stroma with Congo-red (Picture 3); the positive staining was lost by pretreatment with potassium permanganate (Picture 4) and identified Amyloid A protein. Helicobacter py-

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Endoscopic and biopsy findings of the upper digestive tract in patients with amyloidosis

Cited by 160 publications

References 15 publications

Amyloidosis of the colon

Amyloidosis of the colon

Light-chain amyloidosis (AL amyloidosis) presenting as gastrointestinal bleeding

Secondary Amyloidosis Presenting as a Unique form of Nodular Gastritis

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