Endoscopic and histopathological findings in adult dyspeptic patients, and their association with Helicobacter pylori infection in Dhaka, Bangladesh

Tanni, Nusrat Noor; Ahmed, Sharmeen; Anwar, Shaheda; Kismat, Saifa; Halder, Kakali; Nesa, Maherun; Habib, Farjana Binte

doi:10.1016/j.ijregi.2021.11.006

Cited by 2 publications

(3 citation statements)

References 25 publications

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“…In the present study, the H. pylori -positive rate was higher in males and in the 41–50-year age group, which was similar to that observed in another study in Bangladesh [ 10 ]. Although a significant difference was not found, H. pylori -positive cases showed a higher proportion of some risk factors, e.g., residence in rural areas, nonfiltered water, and smoking, compared with H. pylori -negative cases.…”

Section: Discussionsupporting

confidence: 91%

“…While there was a dearth of information in the 2000s, a histological study on the gastric mucosa of patients with abdominal complaints revealed the infection rate of H. pylori to be 60.2% (2008–2010) [ 28 ]. More recent studies on adult dyspeptic patients reported the overall H. pylori prevalence to be 47% (44% with the RUT) (2015) [ 9 ] and 32.9% (with the RUT, PCR, and histology) (2018–2019) [ 10 ]. These detection rates of H. pylori were comparable to our present study showing a prevalence of 36% (the RUT and PCR) among dyspeptic patients in north–central Bangladesh (Mymensingh).…”

Section: Discussionmentioning

confidence: 99%

“…In South Asia, higher seroprevalence of H. pylori in asymptomatic populations was described (>90% in Bangladesh; ~81% in India) compared with other Asian regions more than two decades ago [ 7 , 8 ]. In a recent epidemiological study of H. pylori in Bangladesh, its prevalence was reported to be 33–47% in gastroduodenal biopsy samples obtained through the rapid urease test (RUT) and PCR [ 9 , 10 ]. For the eradication of H. pylori , a triple therapy including a proton pump inhibitor combined with two antimicrobials, amoxicillin (AMX) and clarithromycin (CLA) or metronidazole (MNZ), is the standard first-line regimen.…”

Section: Introductionmentioning

confidence: 99%

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The Prevalence, Risk Factors, and Antimicrobial Resistance Determinants of Helicobacter pylori Detected in Dyspeptic Patients in North–Central Bangladesh

Ferdaus,

Paul,

Nasreen

et al. 2024

Infectious Disease Reports

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Chronic infection of Helicobacter pylori represents a key factor in the etiology of gastrointestinal diseases, with high endemicity in South Asia. The present study aimed to determine the prevalence of H. pylori among dyspeptic patients in north–central Bangladesh (Mymensingh) and analyze risk factors of infection and antimicrobial resistance (AMR) determinants in the pathogen. Endoscopic gastrointestinal biopsy samples were collected from dyspeptic patients for a one-year period from March 2022 and were checked for the presence of H. pylori via the rapid urease test and PCR and further analyzed for the status of virulence factors vacA/cagA and genetic determinants related to AMR via PCR with direct sequencing or RFLP. Among a total of 221 samples collected, 80 (36%) were positive for H. pylori, with the vacA+/cagA+ genotype being detected in almost half of them. H. pylori was most prevalent in the age group of 41–50-year-olds, with it being more common in males and rural residents with a lower economic status and using nonfiltered water, though the rates of these factors were not significantly different from those of the H. pylori-negative group. Relatively higher frequency was noted for the A2147G mutation in 23S rRNA, related to clarithromycin resistance (18%, 7/39). Amino acid substitutions in PBP-1A (T556S) and GyrA (N87K and D91N) and a 200 bp deletion in rdxA were detected in samples from some patients with recurrence after treatment with amoxicillin, levofloxacin, and metronidazole, respectively. The present study describes the epidemiological features of H. pylori infection in the area outside the capital in Bangladesh, revealing the spread of AMR-associated mutations.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Prevalence, Risk Factors, and Antimicrobial Resistance Determinants of Helicobacter pylori Detected in Dyspeptic Patients in North–Central Bangladesh

Ferdaus,

Paul,

Nasreen

et al. 2024

Infectious Disease Reports

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Prevalence and Pattern of Upper Gastrointestinal Lesions in Prospective Kidney Transplant Patients in Bangladesh

Islam,

Kabir,

Bari

et al. 2024

IJN

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Background Upper gastrointestinal (GI) lesions are common in patients with chronic kidney disease and may contribute to anemia and increased morbidity, especially in patients on hemodialysis (HD). They become even more significant in patients undergoing kidney transplantation about to be subjected to lifelong immunosuppressive drugs. Materials and Methods This cross-sectional study conducted at Bangabandhu Sheikh Mujib Medical University’s Departments of Gastroenterology and Nephrology analyzed 128 prospective kidney transplant patients following upper GI endoscopy. Lesions were histopathologically examined and factors contributing to and consequences of the lesions were investigated. Results A total of 52.3% patients had at least one upper GI lesion. Gastritis was the most prevalent one, comprising 55.7% of the lesions, followed by duodenitis (21.6%), ulcer (12.5%), esophagitis (2.3%), and others (8%). Lesions did not vary significantly between symptomatic and asymptomatic patients (p = 0.9). Those on HD had 3.6-fold higher odds of having a lesion (p = 0.005). Patients with lesions had significantly longer CKD duration (p = 0.0002). Mean hemoglobin level was 8.8 g/dl in those with lesions, which was significantly lower compared to those without lesion, who had a mean of 10.3 g/dl (p < 0.0001). Iron deficiency was more common in patients with lesions (p = 0.0004). The mean serum calcium level was significantly higher in patients with lesions (p = 0.0002). Conclusion Upper GI lesions are fairly common in Bangladeshi CKD population. Routine endoscopic screening and treatment of asymptomatic lesions are recommended for advanced CKD patients in Bangladesh, given their frequency and potential impact.

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Endoscopic and histopathological findings in adult dyspeptic patients, and their association with Helicobacter pylori infection in Dhaka, Bangladesh

Cited by 2 publications

References 25 publications

The Prevalence, Risk Factors, and Antimicrobial Resistance Determinants of Helicobacter pylori Detected in Dyspeptic Patients in North–Central Bangladesh

The Prevalence, Risk Factors, and Antimicrobial Resistance Determinants of Helicobacter pylori Detected in Dyspeptic Patients in North–Central Bangladesh

Prevalence and Pattern of Upper Gastrointestinal Lesions in Prospective Kidney Transplant Patients in Bangladesh

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