Endoscopic and Radiographic Evaluation of the Small Bowel in 2012

Dye, Charles; Gaffney, Ryan R.; Dykes, Thomas M.; Moyer, Matthew T.

doi:10.1016/j.amjmed.2012.06.017

Cited by 22 publications

(12 citation statements)

References 59 publications

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“…Capsule endoscopy, enteroscopy, magnetic resonance imaging, computed tomography, X-rays and ultrasound are presently used for assessing gastrointestinal (GI) conditions. 2 Functional imaging of intestinal motor patterns such as peristalsis and segmentation is not usually performed due to lack of accessible, effective, and non-invasive methods. Intestinal motility dysfunction is implicated in diseases such as small bowel bacterial overgrowth 3 , irritable bowel syndrome 4 , inflammatory bowel disease 5 , and constipation 6 .…”

Section: Introductionmentioning

confidence: 99%

Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines

et al. 2014

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OverviewThere is a need for safer and improved methods for non-invasive imaging of the gastrointestinal tract. Modalities based on X-ray radiation, magnetic resonance and ultrasound suffer from limitations with respect to safety, accessibility or lack of adequate contrast. Functional intestinal imaging of dynamic gut processes has not been practical using existing approaches. Here, we report the development of a family of nanoparticles that can withstand the harsh conditions of the stomach and intestine, avoid systemic absorption, and give rise to good optical contrast for photoacoustic imaging. The hydrophobicity of naphthalocyanine dyes was exploited to generate purified ~20 nm frozen micelles, which we call nanonaps, with tunable and large near-infrared absorption values (>1000). Unlike conventional chromophores, nanonaps exhibited non-shifting spectra at ultrahigh optical densities and, following oral administration in mice, passed safely through the gastrointestinal tract. Non-invasive, non-ionizing photoacoustic techniques were used to visualize nanonap intestinal distribution with low background and remarkable resolution with 0.5 cm depth, and enabled real-time intestinal functional imaging with ultrasound co-registration. Positron emission tomography following seamless nanonap radiolabelling allowed complementary whole body imaging.

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Section: Introductionmentioning

confidence: 99%

Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines

et al. 2014

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“…Additionally, histologic evaluation can be performed using DAE, based on VCE or CT/MR enterography findings ( Fig. 2 ) [ 28 , 29 ].…”

Section: Inflammatory Small Bowel Diseasementioning

confidence: 99%

Optimal Diagnostic Approaches for Patients with Suspected Small Bowel Disease

Kim¹,

Moon²

2016

Clin Endosc

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While the domain of gastrointestinal endoscopy has made great strides over the last several decades, endoscopic assessment of the small bowel continues to be challenging. Recently, with the development of new technology including video capsule endoscopy, device-assisted enteroscopy, and computed tomography/magnetic resonance enterography, a more thorough investigation of the small bowel is possible. In this article, we review the systematic approach for patients with suspected small bowel disease based on these advanced endoscopic and imaging systems.

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“…Capsule endoscopy, enteroscopy, magnetic resonance imaging, computed tomography, X-rays and ultrasound (US) are presently used for assessing gastrointestinal (GI) conditions [2], but current approaches are by trial and error. New imaging techniques that safely and non-invasively assess anatomic and functional imaging will lead to better diagnosis and treatment of gut diseases.…”

Section: Introductionmentioning

confidence: 99%

Frozen naphthalocyanine micelles for intestinal imaging

Zhang

Jeon

Rich

et al. 2015

2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC)

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Here we report the development of a family of nanoparticles that can withstand the harsh conditions of the stomach and intestine, avoid systemic absorption, and provide good optical contrast for photoacoustic imaging. The hydrophobicity of naphthalocyanine dyes was exploited to generate frozen micelles (nanonaps), with tunable near-infrared absorption. Nanonaps, following oral administration in mice, passed safely through the gastrointestinal tract. Non-invasive, non-ionizing photoacoustic techniques were used to visualize nanonap intestinal distribution with low background and remarkable resolution, and enabled real-time intestinal functional imaging with ultrasound co-registration.

show abstract

Endoscopic and Radiographic Evaluation of the Small Bowel in 2012

Cited by 22 publications

References 59 publications

Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines

Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines

Optimal Diagnostic Approaches for Patients with Suspected Small Bowel Disease

Frozen naphthalocyanine micelles for intestinal imaging

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