Endoscopic augmentation of the cardia with a biocompatible injectable polymer (Enteryx) in a porcine model

Mason, Rodney J.; Hughes, ME; Lehman, Glen A.; Chiao, Gene; Devière, Jacques; Silverman, David; DeMeester, Tom R.; Peters, Jeffrey H.

doi:10.1007/s004640080189

Cited by 65 publications

(28 citation statements)

References 16 publications

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“…If the material does not come into contact with the surrounding esophageal tissue, no tissue alteration should interfere with a surgical procedure. This was demonstrated in preclinical animal trials [3] and 1 69 12 36 16 22 36 --3 6 2 39 41 39 11 13 38 --3 5 3 35 11 21 10 1 0 0 21 12 28 4 7 2 1 0 2 3 3 9 2 7 2 7 1 7 6 2 4 Fig. 1.…”

Section: Discussionmentioning

confidence: 66%

Laparoscopic Nissen fundoplication after failure of Enteryx injection into the lower esophageal sphincter

et al. 2004

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Section: Discussionmentioning

confidence: 66%

Laparoscopic Nissen fundoplication after failure of Enteryx injection into the lower esophageal sphincter

et al. 2004

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“…The initial study for safety and efficacy of this material was done by Mason et al [55], who injected 12 Yucatan minipigs with Enteryx. Four groups of three animals each were killed at 2, 6, 12, and 24 weeks following implantation.…”

Section: Clinical Studies and Resultsmentioning

confidence: 99%

Endoscopic treatment modalities for gastroesophageal reflux disease

2004

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A debate has been going for decades between surgeons and gastroenterologists about the treatment of choice for gastroesophageal reflux disease (GERD). The lower esophageal sphincter (LES) has been historically far from the reach of gastroenterologists, who adopted the symptomatic treatment as their approach to reflux disease through reduction of gastric acid. As for surgeons, reaching the LES was only possible by invading the thoracic or abdominal cavity. Although their approach was later refined to become "minimally" invasive, it was still deemed too invasive by others to allow it to be the "gold standard." Simple logic should lead one to think about the "natural route" as the easiest way to reach the LES. This concept has opened the door for the new era of GERD treatment through "endoscopic modality." Seven different techniques are currently being used to treat patients with GERD. We review the mechanism of action, potential side effects, efficacy, durability, and results from the most recent or largest experience of each. This review shows that endoscopic treatment has definitely earned its place as a viable option for GERD treatment in selected patients. With the available data from clinical trials, it is not possible to determine the best modality available, and the endoscopic treatment of choice is to be determined with further studies.

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“…Animal studies suggested that implantation is safe and likely efficacious [15]. All animals tolerated the implants without alimentary difficulties or weight loss.…”

Section: Discussionmentioning

confidence: 98%

Lower esophageal sphincter injection of a biocompatible polymer

Peters

Silverman²,

Stein³

2003

Surg Endosc

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Endoscopic augmentation of the cardia with a biocompatible injectable polymer (Enteryx) in a porcine model

Abstract: Augmentation of the cardia with an injectable polymer (Enteryx) is simple, safe, and durable. Early studies suggest that alteration in the distensibility and geometry of the gastroesophageal junction may provide antireflux protection.

Cited by 65 publications

References 16 publications

Laparoscopic Nissen fundoplication after failure of Enteryx injection into the lower esophageal sphincter

Laparoscopic Nissen fundoplication after failure of Enteryx injection into the lower esophageal sphincter

Endoscopic treatment modalities for gastroesophageal reflux disease

Lower esophageal sphincter injection of a biocompatible polymer

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